2-amino-7-phosphonoheptanoic acid has been researched along with Seizures in 64 studies
2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Homocysteine induces seizures in adult, as well as in immature, experimental animals, but the mechanism of its action is still unknown." | 7.69 | NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats. ( Folbergrová, J, 1994) |
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 7.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 7.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 7.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Seizures produced by pilocarpine given i." | 7.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 7.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 7.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 5.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 5.31 | [Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid]. ( Hivanović, D; Stanojlović, O; Susić, V, 2002) |
| "Seizures were induced in immature 18-day-old rats by i." | 5.30 | Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. ( Folbergrová, J, 1997) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 5.30 | APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats. ( Stanojlovic, O; Susic, V; Zivanovic, D, 1997) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 5.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "2APH, 0." | 5.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "We examined the effects of regional infusions of 2-amino-7-phosphonoheptanoic acid (AP7) into the substantia nigra pars reticulata (SNR) in adult male rats on flurothyl-induced clonic seizures." | 3.71 | The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific. ( Hussain, S; Liptáková, S; Velísková, J, 2001) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| " Microinjection of 2-amino-7-phosphonoheptanoic acid, a competitive antagonist of the N-methyl-D-aspartate subclass of the glutamate receptor, into area tempestas prior to systemic administration of kainate attenuated both heat shock protein induction and acid-fuchsin labeling in CA1 and CA3a pyramidal neurons without reducing the duration of electrographic seizures." | 3.69 | Deep prepiriform cortex modulates kainate-induced hippocampal injury. ( Shimosaka, S; Simon, RP; So, YT, 1994) |
| "Homocysteine induces seizures in adult, as well as in immature, experimental animals, but the mechanism of its action is still unknown." | 3.69 | NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats. ( Folbergrová, J, 1994) |
| " The GABAA receptor agonist, muscimol (390 pmol) was microinjected unilaterally into the posterior piriform cortex and adjacent regions in the same hemisphere from which seizures were evoked by focal application of bicuculline into AT." | 3.69 | Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors. ( Gale, K; Halonen, T; Tortorella, A; Zrebeet, H, 1994) |
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 3.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| "Seizures produced by pilocarpine given i." | 3.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 3.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 3.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 3.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| " The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively." | 3.67 | A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. ( Balm, M; Coyle, JT; Markl, A; Zaczek, R, 1986) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 3.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Microinjection of 2-amino-phosphonoheptanoic acid (2APH, 1 nmol), and antagonist for n-methyl-d-aspartate-sensitive receptors, into the deep prepiriform cortex (DPC) of the rat, prevented seizures induced by the intravenous administration of bicuculline." | 3.67 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex. ( Gale, K; Piredda, S, 1986) |
| "The anticonvulsant activity of two competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (APH) and 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP), and two non-competitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), were compared in 4 models of induced seizures in mice." | 3.67 | A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor. ( Arnolde, SM; Nevins, ME, 1989) |
| "The effect of intrahippocampal infusion of 70 nmol (1 microliter/2 min) D,L-2-amino-7-phosphonoheptanoic acid (APH), a selective antagonist of N-methyl-D-aspartate (NMDA)-type receptors, was studied on behavioral seizures and afterdischarge (AD) at different stages of hippocampal kindling in rats." | 3.67 | Role of the N-methyl-D-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats. ( Moneta, E; Samanin, R; Vezzani, A; Wu, HQ, 1988) |
| "Seizures were induced in 12-day-old rats by bilateral intracerebroventricular infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) and oxidative stress was evaluated by in situ detection of superoxide anion (O(2)·(-))." | 1.38 | Brain superoxide anion formation in immature rats during seizures: protection by selected compounds. ( Druga, R; Folbergrová, J; Otáhal, J, 2012) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 1.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 1.31 | [Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid]. ( Hivanović, D; Stanojlović, O; Susić, V, 2002) |
| "Limbic motor seizures in animals, analogous to complex partial seizures in humans, result in a consistent activation of the mediodorsal thalamus (MD) and, with prolonged seizures, damage to MD." | 1.30 | Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. ( Cassidy, RM; Gale, K, 1998) |
| "Naloxone displayed a seizure-suppressant effect that was delayed and incomplete." | 1.30 | The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors. ( Faingold, CL; N'Gouemo, P, 1999) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 1.30 | APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats. ( Stanojlovic, O; Susic, V; Zivanovic, D, 1997) |
| "Seizures were induced in immature 18-day-old rats by i." | 1.30 | Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. ( Folbergrová, J, 1997) |
| "MK-801 had no effect on seizure duration." | 1.30 | Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7. ( Braisted, JC; Chavko, M; Harabin, AL, 1998) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 1.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| "The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex." | 1.29 | In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. ( Abe, S; Akazawa, K; Chishaki, A; Goto, Y; Kato, M; Nakamura, M, 1994) |
| "These audiogenic seizures were blocked with microinjections of 2-amino-7-phosphono-heptanoate (AP7) applied just before 2." | 1.29 | NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei. ( Garcia-Cairasco, N; Terra, VC, 1994) |
| "At 24 h, kindled seizure was readily activated at the GST." | 1.28 | Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats. ( Mori, N; Wada, JA, 1989) |
| "Tonic-clonic seizures were induced by 225-450 mg/kg Quin." | 1.28 | Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. ( Castiglioni, M; Samanin, R; Stasi, MA; Vezzani, A; Weckermann, B; Wu, HQ, 1989) |
| "Experimental febrile seizures can be evoked in epileptic chicks by elevation of their body temperature." | 1.28 | Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists. ( Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI, 1990) |
| "Major seizures were significantly suppressed with the highest dose of AP7 (60 mg/kg) in all groups except 7-day-old rats." | 1.28 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990) |
| "Blockade of these seizures with amino acid antagonists, phosphonocarboxylic acids, was achieved but with a reverse order of potency to that seen with the kindled amygdala." | 1.27 | Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures. ( Bradford, HF; Collins, JF; Peterson, DW, 1984) |
| "Ibotenate-induced seizures and lesions and their specific blockade by a selective antagonist may constitute valuable experimental paradigms for the investigation of seizure disorders." | 1.27 | The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis. ( Aldinio, C; French, ED; Schwarcz, R, 1983) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| "Clonic seizures were induced in Swiss or DBA/2 mice by methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), 0." | 1.27 | Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents. ( Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E, 1985) |
| "Haloperidol pretreatment prevents stereotyped behaviour induced by 2-amino-7-phosphonoheptanoic acid, but does not change the effect on the electroshock test." | 1.27 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra. ( De Sarro, G; Meldrum, BS; Reavill, C, 1984) |
| "We have used limbic convulsions induced by systemic pilocarpine in rats combined with focal intracerebral injections concurrently to study the initiation and spread of seizure activity." | 1.27 | Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "2APH, 0." | 1.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (51.56) | 18.7374 |
| 1990's | 24 (37.50) | 18.2507 |
| 2000's | 5 (7.81) | 29.6817 |
| 2010's | 2 (3.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prigol, M | 1 |
| Brüning, CA | 1 |
| Nogueira, CW | 1 |
| Zeni, G | 1 |
| Folbergrová, J | 4 |
| Otáhal, J | 1 |
| Druga, R | 1 |
| Susić, V | 3 |
| Hivanović, D | 1 |
| Stanojlović, O | 3 |
| Velísek, L | 2 |
| Velísková, J | 2 |
| Giorgi, FS | 1 |
| Moshé, SL | 1 |
| Meldrum, BS | 16 |
| Croucher, MJ | 4 |
| Czuczwar, SJ | 4 |
| Collins, JF | 3 |
| Curry, K | 1 |
| Joseph, M | 1 |
| Stone, TW | 2 |
| Badman, G | 1 |
| Jones, AW | 1 |
| Watkins, JC | 1 |
| Wardley-Smith, B | 3 |
| Halsey, MJ | 3 |
| Peterson, DW | 1 |
| Bradford, HF | 2 |
| Meldrum, B | 3 |
| Aldinio, C | 1 |
| French, ED | 1 |
| Schwarcz, R | 1 |
| Perkins, MN | 1 |
| Wardley-Smit, B | 1 |
| Halsey, M | 1 |
| Rostain, JC | 2 |
| De Sarro, G | 3 |
| Reavill, C | 1 |
| Ammendola, D | 1 |
| Nava, F | 1 |
| De Sarro, A | 1 |
| Shimosaka, S | 1 |
| So, YT | 1 |
| Simon, RP | 2 |
| Terra, VC | 1 |
| Garcia-Cairasco, N | 1 |
| Halonen, T | 1 |
| Tortorella, A | 1 |
| Zrebeet, H | 1 |
| Gale, K | 3 |
| Nakamura, M | 1 |
| Abe, S | 1 |
| Goto, Y | 1 |
| Chishaki, A | 1 |
| Akazawa, K | 1 |
| Kato, M | 1 |
| De Sarro, GB | 1 |
| Bagetta, G | 1 |
| Spagnolo, C | 1 |
| Nisticò, G | 1 |
| Cotterell, KL | 1 |
| Morales-Villagrán, A | 1 |
| Ureña-Guerrero, ME | 1 |
| Tapia, R | 2 |
| Tanaka, K | 1 |
| Graham, SH | 1 |
| Zivanovic, D | 2 |
| Chavko, M | 1 |
| Braisted, JC | 1 |
| Harabin, AL | 1 |
| Cassidy, RM | 1 |
| N'Gouemo, P | 1 |
| Faingold, CL | 3 |
| Haugvicová, R | 1 |
| Mares, P | 2 |
| Manjarrez, J | 1 |
| Alvarado, R | 1 |
| Camacho-Arroyo, I | 1 |
| Liptáková, S | 1 |
| Hussain, S | 1 |
| Engelsen, BA | 1 |
| Fonnum, F | 1 |
| Furset, K | 1 |
| Ferkany, JW | 1 |
| Kyle, DJ | 1 |
| Ellenberger, WP | 1 |
| Narayanan, BA | 1 |
| Ellenberger, SR | 1 |
| Hudkins, R | 1 |
| Guzewska, ME | 1 |
| Rzeszotarski, WJ | 1 |
| Conti, L | 1 |
| Patch, R | 1 |
| Fragoso-Veloz, J | 1 |
| Skolnick, P | 1 |
| Miller, R | 1 |
| Young, A | 1 |
| Boje, K | 1 |
| Trullas, R | 1 |
| Xie, XH | 1 |
| Tietz, EI | 1 |
| Rosenberg, HC | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
| Holmes, GL | 1 |
| Thompson, JL | 1 |
| Carl, GF | 1 |
| Gallagher, BS | 1 |
| Hoy, J | 1 |
| McLaughlin, M | 1 |
| Kusá, R | 1 |
| Kulovaná, M | 1 |
| Mori, N | 1 |
| Wada, JA | 1 |
| Vezzani, A | 3 |
| Stasi, MA | 2 |
| Wu, HQ | 3 |
| Castiglioni, M | 1 |
| Weckermann, B | 1 |
| Samanin, R | 3 |
| Millan, MH | 7 |
| Nevins, ME | 1 |
| Arnolde, SM | 1 |
| McCaslin, PP | 1 |
| Morgan, WW | 1 |
| Janusz, W | 1 |
| Wamil, A | 1 |
| Kleinrok, Z | 2 |
| Moneta, E | 1 |
| Patel, S | 5 |
| Chapman, AG | 2 |
| Cheetham, SC | 1 |
| Hart, GP | 1 |
| Westerberg, E | 1 |
| Cavalheiro, EA | 2 |
| Turski, L | 2 |
| Turski, WA | 2 |
| Dewhurst, DG | 1 |
| Angelico, P | 1 |
| Mello, LM | 2 |
| Millan, M | 1 |
| Engelsen, B | 1 |
| Boersma, CA | 2 |
| Zaczek, R | 1 |
| Markl, A | 1 |
| Balm, M | 1 |
| Coyle, JT | 1 |
| Piredda, S | 1 |
1 review available for 2-amino-7-phosphonoheptanoic acid and Seizures
| Article | Year |
|---|---|
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
63 other studies available for 2-amino-7-phosphonoheptanoic acid and Seizures
| Article | Year |
|---|---|
The role of the glutathione system in seizures induced by diphenyl diselenide in rat pups.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzene Derivatives; Buthionine Sulfoximine; | 2011 |
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2012 |
[Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid].
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Male; Phencyclidine; Rats; Rats, Wistar; Seiz | 2002 |
Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development.
Topics: 2-Amino-5-phosphonovalerate; Acrylates; Age Factors; Analysis of Variance; Animals; Animals, Newborn | 2006 |
A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1983 |
Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Glutamates; Papio; Photic Stimul | 1983 |
Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1984 |
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Brain; Fasti | 1984 |
Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Animals; Anticonvulsants; Cerebral Ventric | 1984 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kain | 1982 |
The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Dose-Response Relationship, Dru | 1983 |
On the interaction of 2-amino-7-phosphono-heptanoic acid and quinolinic acid in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Iontophoresis; | 1983 |
2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsies, Myoclonic; Male | 1983 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Caudate Nucleus; Electroshock; Haloperidol; Hippo | 1984 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvuls | 1995 |
Deep prepiriform cortex modulates kainate-induced hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; El | 1994 |
NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Dizocilpine Ma | 1994 |
NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Brain Mapp | 1994 |
Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Entorhinal Cort | 1994 |
In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Body Weight; Dizocilpine Maleate | 1994 |
Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Mal | 1993 |
Characterisation of N-methyl-D-aspartate (NMDA)-induced kindling.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Anticonvulsants; Electroencephalography | 1996 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Mal | 1996 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistr | 1997 |
APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Electroenc | 1997 |
Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Cerebr | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisoto | 1998 |
The anticonvulsant potency of (+/-)-2-Amino-7-phosphonoheptanoic acid and (+/-)-2-amino-5-phosphonovaleric acid against metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid A | 1998 |
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagoni | 1999 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizo | 2001 |
The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Dose-Response Relationship, Drug; Excitatory Amin | 2001 |
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amino Acids; Animals; Anticonvulsants; Brain Mapping; Caudate | 1992 |
Pharmacological profile of novel cyclic analogs of 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Brain; Dose-Response Relationshi | 1992 |
NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acids; Animals; Behavior, Animal; Male; N-Methyl | 1992 |
Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anticonvulsants; Antidepress | 1992 |
Anti-pentylenetetrazol effect of intranigral 2-amino-7-phosphonoheptanoate attenuated by muscimol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Drug Combinations; Male; Muscimo | 1991 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid | 1990 |
Effect of 2-amino-7-phosphonoheptanoic acid (APH) on seizure susceptibility in the prepubescent and mature rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Injections, Intraventricular; Kindling, Neurologi | 1990 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen | 1990 |
Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Basal Ganglia; Male; Rats; Receptors, N | 1989 |
Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood-Brain Barrier; Cerebral Co | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; G | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpin | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Role of the N-methyl-D-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Electric Stimulation; Hippocam | 1988 |
Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Injections; Limbic System; Male; | 1988 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cereb | 1985 |
Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; El | 1985 |
Possible role of excitatory amino acids in the convulsant action of catechol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Catechols; Dibenzocycloheptenes; Dipeptides; Dizo | 1988 |
Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Calcium; Dialysis; Dose-Response Relationship, Dr | 1988 |
2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Male; Muscimol; N | 1986 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalog | 1986 |
Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Cerebellum; Limbic System; Male; M | 1987 |
2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Ce | 1987 |
Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Afferent Pathways; Amino Acids; Animals; Genicula | 1988 |
Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Efferent Pathways; Female; | 1988 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diaz | 1986 |
Effect of 2-aminophosphonoheptanoic acid on the EEG of rats exposed to high pressure.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Central Nervous System Dise | 1986 |
Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Limbic System; Male; Pilocarpine | 1986 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Ma | 1986 |