2-amino-7-phosphonoheptanoic acid has been researched along with Epilepsy in 13 studies
2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Slamberová, R | 1 |
| Mares, P | 2 |
| Raisinghani, M | 1 |
| Faingold, CL | 1 |
| Peterson, DW | 1 |
| Collins, JF | 1 |
| Bradford, HF | 1 |
| Faingold, C | 1 |
| Casebeer, D | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Cook, CJ | 1 |
| Devine, CE | 1 |
| Tavener, A | 1 |
| Gilbert, KV | 1 |
| De Sarro, G | 2 |
| Meldrum, BS | 2 |
| De Sarro, A | 1 |
| Patel, S | 2 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Watson, GB | 2 |
| Lanthorn, TH | 2 |
| Millan, MH | 1 |
| Wardley-Smith, B | 1 |
| Dürmüller, N | 1 |
| Peeters, BW | 1 |
| van Rijn, CM | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Rader, RK | 1 |
| Meldrum, B | 1 |
| Millan, M | 1 |
1 review available for 2-amino-7-phosphonoheptanoic acid and Epilepsy
| Article | Year |
|---|---|
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
12 other studies available for 2-amino-7-phosphonoheptanoic acid and Epilepsy
| Article | Year |
|---|---|
Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Ep | 2005 |
Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Analysis of Variance; Animals; | 2005 |
The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Amygdala; Animals; Anticonvulsants; Epilep | 1983 |
Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Adrenergic alpha-Agonists; Animals; Epilepsy; Exc | 1999 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Contribution of amino acid transmitters to epileptiform activity and reflex suppression in electrically head stunned sheep.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Baclofen; Bicuculline; Blinking; | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencepha | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro | 1990 |
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsy; Female; Male; Myo | 1991 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dos | 1990 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitr | 1989 |