2-amino-7-phosphonoheptanoic acid has been researched along with Drug Withdrawal Symptoms in 2 studies
2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, M | 1 |
| Milne, B | 1 |
| Jhamandas, K | 1 |
| McCaslin, PP | 1 |
| Morgan, WW | 1 |
2 other studies available for 2-amino-7-phosphonoheptanoic acid and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Evidence for the involvement of excitatory amino acid pathways in the development of precipitated withdrawal from acute and chronic morphine: an in vivo voltammetric study in the rat locus coeruleus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Ventricles; Dipeptides; Excitatory Amino | 1993 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |