Compounds > 2-amino-7-phosphonoheptanoic acid
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2-amino-7-phosphonoheptanoic acid and Brain Ischemia

2-amino-7-phosphonoheptanoic acid has been researched along with Brain Ischemia in 5 studies

2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19902 (40.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Simon, RP1
Swan, JH2
Griffiths, T1
Meldrum, BS2
Zhang, Y1
Wong, KC1
Hayes, JK1
Plachinta, R1
Bazil, MK1
Gordon, FJ1
Jensen, ML1
Auer, RN1

Other Studies

5 other studies available for 2-amino-7-phosphonoheptanoic acid and Brain Ischemia

ArticleYear
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
    Science (New York, N.Y.), 1984, Nov-16, Volume: 226, Issue:4676

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Hippocampus; Rats; Receptors, N-M

1984
Excitatory amino acid receptor antagonist 2APH may improve local CBF during cerebral ischemia in cats.
    Acta anaesthesiologica Sinica, 2001, Volume: 39, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Excitatory

2001
Effect of blockade of spinal NMDA receptors on sympathoexcitation and cardiovascular responses produced by cerebral ischemia.
    Brain research, 1991, Jul-26, Volume: 555, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Ischemia; Cardiovascular Sy

1991
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Isch

1990
Intraventricular infusion of 2-amino-7-phosphonoheptanoate (APH) mitigates ischaemic brain damage.
    Neurological research, 1989, Volume: 11, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Injections, Intraventricular; Mal

1989