2-amino-7-phosphonoheptanoic acid and Aging studies

2-amino-7-phosphonoheptanoic acid and Aging

2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

Excerpt	Relevance	Reference
"Major seizures were significantly suppressed with the highest dose of AP7 (60 mg/kg) in all groups except 7-day-old rats."	1.28	Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

4 (100.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Pazzagli, M	1
Corsi, C	1
Fratti, S	1
Pedata, F	1
Pepeu, G	1
Navarro, CE	1
Cabrera, RJ	1
Donoso, AO	1
Marret, S	1
Gressens, P	1
Evrard, P	1
Velísek, L	1
Kusá, R	1
Kulovaná, M	1
Mares, P	1

Studies

Pazzagli, M

Corsi, C

Fratti, S

Pedata, F

Pepeu, G

Navarro, CE

Cabrera, RJ

Donoso, AO

Marret, S

Gressens, P

Evrard, P

Velísek, L

Kusá, R

Kulovaná, M

Mares, P

Other Studies

4 other studies available for 2-amino-7-phosphonoheptanoic acid and Aging

Article	Year
Regulation of extracellular adenosine levels in the striatum of aging rats. Brain research, 1995, Jun-26, Volume: 684, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; A	1995
Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging. Brain research bulletin, 1994, Volume: 33, Issue:6 Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glut	1994
Arrest of neuronal migration by excitatory amino acids in hamster developing brain. Proceedings of the National Academy of Sciences of the United States of America, 1996, Dec-24, Volume: 93, Issue:26 Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Animals, Newborn; Brain; Cell Differentiation;	1996
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. Life sciences, 1990, Volume: 46, Issue:19 Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen	1990

Article

Year

Regulation of extracellular adenosine levels in the striatum of aging rats.

Brain research, 1995, Jun-26, Volume: 684, Issue:1

Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; A

1995

Release of 3H-noradrenaline by excitatory amino acids from rat mediobasal hypothalamus and the influence of aging.

Brain research bulletin, 1994, Volume: 33, Issue:6

Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Glut

1994

Arrest of neuronal migration by excitatory amino acids in hamster developing brain.

Proceedings of the National Academy of Sciences of the United States of America, 1996, Dec-24, Volume: 93, Issue:26

Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; Animals; Animals, Newborn; Brain; Cell Differentiation;

1996

Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.

Life sciences, 1990, Volume: 46, Issue:19

Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen

1990