2-amino-7-phosphonoheptanoic acid has been researched along with Ache in 6 studies
2-amino-7-phosphonoheptanoic acid: (D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent electrophysiological studies by our group have suggested that increased excitation of spinal GABAergic neurons by activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors following intradermal injection of capsaicin results in the generation of DRRs that contribute to neurogenic inflammation." | 3.71 | NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats. ( Lin, Q; Willis, WD; Zou, X, 2001) |
| "Pretreatment with mexiletine (5-30 mg/kg i." | 1.30 | Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat. ( Hodge, E; Khandwala, H; Loomis, CW, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haghparast, A | 1 |
| Gheitasi, IP | 1 |
| Lashgari, R | 1 |
| Lawand, NB | 1 |
| Willis, WD | 2 |
| Westlund, KN | 1 |
| Khandwala, H | 1 |
| Hodge, E | 1 |
| Loomis, CW | 1 |
| Zou, X | 1 |
| Lin, Q | 1 |
| Kao, MC | 1 |
| Lee, HK | 1 |
| Chai, CY | 1 |
| Wang, Y | 1 |
| Jacquet, YF | 1 |
6 other studies available for 2-amino-7-phosphonoheptanoic acid and Ache
| Article | Year |
|---|---|
Involvement of glutamatergic receptors in the nucleus cuneiformis in modulating morphine-induced antinociception in rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Dizocilpine Maleate; Excitatory Amino Acid | 2007 |
Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Excitatory Amino Acid An | 1997 |
Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Foot; Hyperesthesia; Male; M | 1997 |
NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blotting, Western; Capsa | 2001 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occl | 1991 |
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Analgesia; Animals; Aspartic Acid; Kainic Acid; Male; Morp | 1988 |