2-amino-5-phosphonovalerate has been researched along with Substance Withdrawal Syndrome in 27 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effective doses of these compounds were lower than those required to prevent seizures due to NMDA in naive animals; these were in turn lower than those needed to prevent the convulsive effects of the alpha-aminobutyric acid (GABA) antagonist, bicuculline." | 3.69 | Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence. ( Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q, 1994) |
| " Hippocampi aged in vitro were significantly more sensitive to the toxic effects of multiple cycles of CIE than were non-aged hippocampi." | 1.42 | Ethanol withdrawal is required to produce persisting N-methyl-D-aspartate receptor-dependent hippocampal cytotoxicity during chronic intermittent ethanol exposure. ( Berry, JN; Prendergast, MA; Reynolds, AR; Sharrett-Field, L, 2015) |
| "Morphine has long been known to affect VTA DA cells via GABAergic interneurons." | 1.42 | Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. ( Aston-Jones, G; Kaufling, J, 2015) |
| "Verapamil was used to isolate NMDA-dependent LTP." | 1.32 | Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus. ( Fathollahi, Y; Kazemnejad, A; Salmanzadeh, F; Semnanian, S; Shafizadeh, M, 2003) |
| "Morphine was administered in a single dose (300 mg/kg) of a slow release preparation." | 1.30 | Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists. ( Cabello, P; Contreras, E; Germany, A; González, P; Norris, B, 1997) |
| "The increase in seizure sensitivity of repeatedly withdrawn mice was prevented by treatment with the NMDA receptor antagonist CGP 39551 (20 mg/kg, i." | 1.30 | Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist. ( Dunworth, SJ; Stephens, DN, 1998) |
| " The increased severity of withdrawal, when sufficient time was left for washout of CGP39551, suggests that chronic administration of CGP39551 increased the adaptive changes that cause or contribute to ethanol withdrawal hyperexcitability." | 1.29 | Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist. ( Little, HJ; Ripley, TL, 1995) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 5 (18.52) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qian, Z | 1 |
| Wu, X | 2 |
| Qiao, Y | 1 |
| Shi, M | 2 |
| Liu, Z | 2 |
| Ren, W | 2 |
| Han, J | 1 |
| Zheng, Q | 1 |
| Fu, R | 1 |
| Zuo, W | 1 |
| Shiwalkar, N | 1 |
| Mei, Q | 1 |
| Fan, Q | 1 |
| Chen, X | 1 |
| Li, J | 1 |
| Bekker, A | 1 |
| Ye, JH | 1 |
| Coleman, BR | 1 |
| Carlezon, WA | 1 |
| Myers, KM | 1 |
| Heinl, C | 1 |
| Drdla-Schutting, R | 1 |
| Xanthos, DN | 1 |
| Sandkühler, J | 1 |
| Wei, C | 1 |
| Yang, M | 1 |
| Liu, Y | 1 |
| Zhang, X | 1 |
| Salmanzadeh, F | 1 |
| Fathollahi, Y | 1 |
| Semnanian, S | 1 |
| Shafizadeh, M | 1 |
| Kazemnejad, A | 1 |
| Faleiro, LJ | 1 |
| Jones, S | 1 |
| Kauer, JA | 1 |
| Rabbani, M | 2 |
| Wright, EJ | 1 |
| Little, HJ | 4 |
| Ripley, TL | 2 |
| Lamblin, F | 1 |
| Deuceuninck, D | 1 |
| De Witte, P | 1 |
| Morrisett, RA | 1 |
| Wright, J | 1 |
| Butterworth, AR | 1 |
| Zhou, Q | 1 |
| Koyuncuoğlu, H | 1 |
| Hatipoğlu, I | 1 |
| Sarica, O | 1 |
| Hong, M | 1 |
| Milne, B | 1 |
| Jhamandas, K | 1 |
| Bonci, A | 1 |
| Williams, JT | 1 |
| González, P | 1 |
| Cabello, P | 1 |
| Germany, A | 1 |
| Norris, B | 1 |
| Contreras, E | 1 |
| Dunworth, SJ | 1 |
| Stephens, DN | 1 |
| Ivanov, A | 1 |
| Aston-Jones, G | 2 |
| Harvey, BH | 1 |
| Jonker, LP | 1 |
| Brand, L | 1 |
| Heenop, M | 1 |
| Stein, DJ | 1 |
| Liljequist, S | 1 |
| McCaslin, PP | 1 |
| Morgan, WW | 1 |
| Reynolds, AR | 1 |
| Berry, JN | 1 |
| Sharrett-Field, L | 1 |
| Prendergast, MA | 1 |
| Kaufling, J | 1 |
| Li, YQ | 1 |
| Xue, YX | 1 |
| He, YY | 1 |
| Li, FQ | 1 |
| Xue, LF | 1 |
| Xu, CM | 1 |
| Sacktor, TC | 1 |
| Shaham, Y | 1 |
| Lu, L | 1 |
| Dong, Z | 1 |
| Zhong, W | 1 |
| Tian, M | 1 |
| Han, H | 1 |
| Mao, R | 1 |
| Cao, J | 1 |
| Sui, N | 1 |
| Xu, T | 1 |
| Luo, J | 1 |
| Xu, L | 1 |
| Chieng, B | 1 |
| Christie, MD | 1 |
27 other studies available for 2-amino-5-phosphonovalerate and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Downregulation of mGluR2/3 receptors during morphine withdrawal in rats impairs mGluR2/3- and NMDA receptor-dependent long-term depression in the nucleus accumbens.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Bridged Bicyclo Compounds, Heterocyclic; Down-Reg | 2019 |
Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Be | 2019 |
Extinction of conditioned opiate withdrawal in rats is blocked by intracerebroventricular infusion of an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Conditioning, Classical; Extinction, Psych | 2013 |
Distinct mechanisms underlying pronociceptive effects of opioids.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela | 2011 |
Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analysis of Variance | 2012 |
Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Calcium Channel Blockers; Cognition; Electri | 2003 |
Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 2004 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; | 1995 |
Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Drug Administration Schedule; Ethanol; Handling, Psychological | 1995 |
Modulation of alcohol preference by NMDA antagonists in male rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain; Capillary Permeability; Choice Behavi | 1993 |
Potentiation of N-methyl-D-aspartate receptor-dependent afterdischarges in rat dentate gyrus following in vitro ethanol withdrawal.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Ethanol; Hippocampus; Kynurenic Acid; Magne | 1994 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; H | 1994 |
Morphine physical dependence intensification by hypoglycemia: NMDA receptor involvement.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain; Dizocilpine Maleate; Hypoglycemia; In | 1994 |
Evidence for the involvement of excitatory amino acid pathways in the development of precipitated withdrawal from acute and chronic morphine: an in vivo voltammetric study in the rat locus coeruleus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Ventricles; Dipeptides; Excitatory Amino | 1993 |
Ethanol withdrawal hyperexcitability in vitro is selectively decreased by a competitive NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Ac | 1995 |
Increased probability of GABA release during withdrawal from morphine.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenylyl Cycla | 1997 |
Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Ant | 1997 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino A | 1998 |
Local opiate withdrawal in locus coeruleus neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bari | 2001 |
NMDA receptor involvement in imipramine withdrawal-associated effects on swim stress, GABA levels and NMDA receptor binding in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Chromatogr | 2002 |
The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Diet; Dizocilpine Maleate; Ethanol; Hippocampus; Mice; Mice, I | 1991 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
Ethanol withdrawal is required to produce persisting N-methyl-D-aspartate receptor-dependent hippocampal cytotoxicity during chronic intermittent ethanol exposure.
Topics: Animals; Antigens, Nuclear; Central Nervous System Depressants; Ethanol; Hippocampus; Immunohistoche | 2015 |
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathways; Animals; Channelrhodopsi | 2015 |
Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Dopamine Uptake Inh | 2011 |
Morphine withdrawal affects both delayed-escape behaviour in Morris water maze and hippocampal NR2A/2B expression ratio.
Topics: Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Escape Reaction; Excitatory | 2008 |
Local opioid withdrawal in rat single periaqueductal gray neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Baclof | 1996 |