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2-amino-5-phosphonovalerate and Stiff-Person Syndrome

2-amino-5-phosphonovalerate has been researched along with Stiff-Person Syndrome in 1 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Stiff-Person Syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xiong, W1
Chen, SR1
He, L1
Cheng, K1
Zhao, YL1
Chen, H1
Li, DP1
Homanics, GE1
Peever, J1
Rice, KC1
Wu, LG1
Pan, HL1
Zhang, L1

Other Studies

1 other study available for 2-amino-5-phosphonovalerate and Stiff-Person Syndrome

ArticleYear
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.
    Nature neuroscience, 2014, Volume: 17, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Disease Models, Animal; Excitatory Amino

2014