2-amino-5-phosphonovalerate has been researched along with Status Epilepticus in 10 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 7.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 5.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 3.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| "We studied the efficacy of the competitive NMDA receptor antagonist CGP 40116 in protecting against seizure-induced neuronal necrosis from lithium-pilocarpine-induced status epilepticus (SE)." | 3.69 | The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. ( Daniels, AH; Fujikawa, DG; Kim, JS, 1994) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 1.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| "Status epilepticus was induced by intravenous kainate (15 mg/kg) and neuronal death was assessed in hippocampal CA3 sector 72 h following status epilepticus." | 1.30 | Non-NMDA but not NMDA blockade at deep prepiriform cortex protects against hippocampal cell death in status epilepticus. ( Kawaguchi, K; Simon, RP, 1997) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ivanov, AD | 1 |
| Zaitsev, AV | 2 |
| Rejdak, K | 1 |
| Nieoczym, D | 1 |
| Czuczwar, M | 1 |
| Kiś, J | 1 |
| Wlaź, P | 1 |
| Turski, WA | 1 |
| Kryukov, KA | 1 |
| Kim, KK | 1 |
| Magazanik, LG | 1 |
| Barmashenko, G | 1 |
| Hefft, S | 1 |
| Aertsen, A | 1 |
| Kirschstein, T | 1 |
| Köhling, R | 1 |
| Tu, B | 1 |
| Timofeeva, O | 1 |
| Jiao, Y | 1 |
| Nadler, JV | 1 |
| Fujikawa, DG | 1 |
| Daniels, AH | 1 |
| Kim, JS | 1 |
| Tanaka, K | 1 |
| Graham, SH | 1 |
| Simon, RP | 2 |
| Kawaguchi, K | 1 |
| Fornai, F | 1 |
| Bassi, L | 1 |
| Gesi, M | 1 |
| Giorgi, FS | 1 |
| Guerrini, R | 1 |
| Bonaccorsi, I | 1 |
| Alessandrì, MG | 1 |
| González, MI | 1 |
| Grabenstatter, HL | 1 |
| Cea-Del Rio, CA | 1 |
| Cruz Del Angel, Y | 1 |
| Carlsen, J | 1 |
| Laoprasert, RP | 1 |
| White, AM | 1 |
| Huntsman, MM | 1 |
| Brooks-Kayal, A | 1 |
10 other studies available for 2-amino-5-phosphonovalerate and Status Epilepticus
| Article | Year |
|---|---|
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electroencephalography; | 2014 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocam | 2016 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Benzazepines; Bicuculline; Convulsants; Dentate Gyru | 2005 |
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Electroenc | 1994 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Non-NMDA but not NMDA blockade at deep prepiriform cortex protects against hippocampal cell death in status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Cell Death; Drug Evaluation, Preclinical; Exc | 1997 |
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Denervation; Dose-Response Relationship, Drug; Ep | 2000 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |