2-amino-5-phosphonovalerate has been researched along with Spinal Cord Injuries in 9 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Margaryan, G | 1 |
| Mattioli, C | 1 |
| Mladinic, M | 1 |
| Nistri, A | 1 |
| Joynes, RL | 1 |
| Janjua, K | 1 |
| Grau, JW | 1 |
| Doyle, LM | 1 |
| Roberts, BL | 1 |
| Craenen, G | 1 |
| Jeftinija, S | 1 |
| Grants, I | 1 |
| Lucas, JH | 2 |
| Rossignol, S | 1 |
| Giroux, N | 1 |
| Chau, C | 1 |
| Marcoux, J | 1 |
| Brustein, E | 1 |
| Reader, TA | 1 |
| Wang, GF | 1 |
| Gross, GW | 1 |
| Vural, M | 1 |
| Arslantaş, A | 1 |
| Yazihan, N | 1 |
| Köken, T | 1 |
| Uzuner, K | 1 |
| Arslantaş, D | 1 |
| Ozbek, Z | 1 |
| Garraway, SM | 1 |
| Anderson, AJ | 1 |
| Mendell, LM | 1 |
| Bennett, AD | 1 |
| Everhart, AW | 1 |
| Hulsebosch, CE | 1 |
9 other studies available for 2-amino-5-phosphonovalerate and Spinal Cord Injuries
| Article | Year |
|---|---|
Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cell S | 2010 |
Instrumental learning within the spinal cord: VI. The NMDA receptor antagonist, AP5, disrupts the acquisition and maintenance of an acquired flexion response.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; | 2004 |
NMDA receptor blockade retards axonal growth in the transected spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Anguilla; Animals; Axons; Behavior, Animal; Carbocyanines; Drug Implant | 2004 |
The role of excitatory amino acids in hypothermic injury to mammalian spinal cord neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Deat | 1996 |
Pharmacological aids to locomotor training after spinal injury in the cat.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic alpha-Antagonists; Animals; Cats; Clonidine; Excitatory Amin | 2001 |
NMDA antagonists prevent hypothermic injury and death of mammalian spinal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Dizocilpine Maleate; Female; Freezing; Hypother | 1990 |
NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats.
Topics: Animals; Disease Models, Animal; Glutathione; Malondialdehyde; Neuroprotective Agents; Oxidative Str | 2010 |
BDNF-induced facilitation of afferent-evoked responses in lamina II neurons is reduced after neonatal spinal cord contusion injury.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; alpha-Amino-3-hydroxy-5-methyl | 2005 |
Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino | 2000 |