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2-amino-5-phosphonovalerate and Spasms, Infantile

2-amino-5-phosphonovalerate has been researched along with Spasms, Infantile in 3 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)

Research Excerpts

ExcerptRelevanceReference
" Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques."7.68Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993)
" Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques."3.68Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joshi, K1
Shen, L1
Cao, F1
Dong, S1
Jia, Z1
Cortez, MA1
Snead, OC1
Kim, YI2
Peacock, WJ2
Dudek, FE2
Wuarin, JP1
Cepeda, C1
Tasker, JG1
Walsh, JP1
Buchwald, NA1

Other Studies

3 other studies available for 2-amino-5-phosphonovalerate and Spasms, Infantile

ArticleYear
Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome.
    Epilepsy research, 2018, Volume: 145

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relatio

2018
Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy.
    Journal of neurophysiology, 1993, Volume: 70, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Cult

1993
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
    Annals of neurology, 1990, Volume: 28, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB

1990