2-amino-5-phosphonovalerate has been researched along with Seizures in 152 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epileptic seizures have been reported in patients on imipenem/cilastatin (Imi/Cil) therapy." | 7.72 | Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats. ( Lovic, OS; Susic, V; Zivanovic, D, 2004) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 7.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| " Seizures were evoked with bicuculline (3." | 7.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 7.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "Homocysteine induces seizures in adult, as well as in immature, experimental animals, but the mechanism of its action is still unknown." | 7.69 | NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats. ( Folbergrová, J, 1994) |
| "The biologically active enantiomer (CGP 40116) of the new competitive N-methyl-D-aspartate (NMDA) receptor antagonist CGP 37849 was investigated for its effects on pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse." | 7.69 | The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse. ( Starr, BS; Starr, MS, 1994) |
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 7.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 7.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 7.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 7.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Seizures produced by pilocarpine given i." | 7.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 7.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 7.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 7.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 5.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 5.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 5.31 | [Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid]. ( Hivanović, D; Stanojlović, O; Susić, V, 2002) |
| "Seizures were induced in immature 18-day-old rats by i." | 5.30 | Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. ( Folbergrová, J, 1997) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 5.30 | APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats. ( Stanojlovic, O; Susic, V; Zivanovic, D, 1997) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 5.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "2APH, 0." | 5.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| " Daily repeated epileptic seizures were induced for 12 days by intraperitoneal administration of 4-aminopyridine (4-AP; 4." | 3.75 | Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures. ( Bakos, M; Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Szucs, B; Világi, I; Vincze, A, 2009) |
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| "Epileptic seizures have been reported in patients on imipenem/cilastatin (Imi/Cil) therapy." | 3.72 | Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats. ( Lovic, OS; Susic, V; Zivanovic, D, 2004) |
| "We examined the effects of regional infusions of 2-amino-7-phosphonoheptanoic acid (AP7) into the substantia nigra pars reticulata (SNR) in adult male rats on flurothyl-induced clonic seizures." | 3.71 | The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific. ( Hussain, S; Liptáková, S; Velísková, J, 2001) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| " Seizures were evoked with bicuculline (3." | 3.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| "The aim of this study was to evaluate the effect of N-methyl-D-aspartate (NMDA) and kainate used at nonconvulsive doses upon protective efficacy of chlormethiazole against maximal electroshock-induced seizures." | 3.70 | Chlormethiazole anticonvulsive efficacy diminished by N-methyl-D-aspartate but not kainate in mice. ( Czuczwar, SJ; Kleinrok, Z; Pilip, S; Turski, WA; Urbanska, EM, 1998) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 3.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 3.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "Homocysteine induces seizures in adult, as well as in immature, experimental animals, but the mechanism of its action is still unknown." | 3.69 | NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats. ( Folbergrová, J, 1994) |
| " Microinjection of 2-amino-7-phosphonoheptanoic acid, a competitive antagonist of the N-methyl-D-aspartate subclass of the glutamate receptor, into area tempestas prior to systemic administration of kainate attenuated both heat shock protein induction and acid-fuchsin labeling in CA1 and CA3a pyramidal neurons without reducing the duration of electrographic seizures." | 3.69 | Deep prepiriform cortex modulates kainate-induced hippocampal injury. ( Shimosaka, S; Simon, RP; So, YT, 1994) |
| "The biologically active enantiomer (CGP 40116) of the new competitive N-methyl-D-aspartate (NMDA) receptor antagonist CGP 37849 was investigated for its effects on pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse." | 3.69 | The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse. ( Starr, BS; Starr, MS, 1994) |
| " The effective doses of these compounds were lower than those required to prevent seizures due to NMDA in naive animals; these were in turn lower than those needed to prevent the convulsive effects of the alpha-aminobutyric acid (GABA) antagonist, bicuculline." | 3.69 | Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence. ( Butterworth, AR; Little, HJ; Rabbani, M; Wright, J; Zhou, Q, 1994) |
| " The GABAA receptor agonist, muscimol (390 pmol) was microinjected unilaterally into the posterior piriform cortex and adjacent regions in the same hemisphere from which seizures were evoked by focal application of bicuculline into AT." | 3.69 | Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors. ( Gale, K; Halonen, T; Tortorella, A; Zrebeet, H, 1994) |
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 3.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "To investigate the possible role of N-methyl-D-aspartate (NMDA) receptors in the development and expression of amygdaloid-kindled seizures, rats were either chronically infused with 2-amino-5-phosphonovalerate (APV, 20-40 mM) or pre-injected with carboxypiperazine-phosphonate (CPP, 1-10 mg/kg), both selective NMDA-receptor antagonists, and then kindled from the amygdala." | 3.68 | The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures. ( Bilkey, DK; Goddard, GV; Holmes, KH; Laverty, R, 1990) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 3.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 3.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| "Intraperitoneal injection of pilocarpine (380 mg/kg) produces motor limbic seizures in rats." | 3.67 | Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| " The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively." | 3.67 | A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties. ( Balm, M; Coyle, JT; Markl, A; Zaczek, R, 1986) |
| "Seizures, neuronal damage and extracellular Ca2+ concentration were studied in rats unilaterally injected in the dorsal hippocampus with quinolinic acid, a brain metabolite with excitotoxic properties." | 3.67 | Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis. ( Angelico, P; Samanin, R; Stasi, MA; Vezzani, A; Wu, HQ, 1988) |
| " tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg)." | 3.67 | The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats. ( Halsey, MJ; Meldrum, BS; Wardley-Smith, B, 1984) |
| "Strychnine poisoning leads to seizures that have traditionally been attributed to competitive antagonism of glycine receptors in the spinal cord." | 3.67 | Glycine potentiates strychnine-induced convulsions: role of NMDA receptors. ( Beitz, AJ; Larson, AA, 1988) |
| "In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region." | 3.67 | Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid. ( Lason, W; McGinty, JF; Simpson, JN, 1988) |
| "Seizures produced by pilocarpine given i." | 3.67 | Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate. ( Cavalheiro, EA; Meldrum, BS; Turski, L; Turski, WA, 1986) |
| "The effect of intrahippocampal infusion of 70 nmol (1 microliter/2 min) D,L-2-amino-7-phosphonoheptanoic acid (APH), a selective antagonist of N-methyl-D-aspartate (NMDA)-type receptors, was studied on behavioral seizures and afterdischarge (AD) at different stages of hippocampal kindling in rats." | 3.67 | Role of the N-methyl-D-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats. ( Moneta, E; Samanin, R; Vezzani, A; Wu, HQ, 1988) |
| "Microinjection of 2-amino-phosphonoheptanoic acid (2APH, 1 nmol), and antagonist for n-methyl-d-aspartate-sensitive receptors, into the deep prepiriform cortex (DPC) of the rat, prevented seizures induced by the intravenous administration of bicuculline." | 3.67 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex. ( Gale, K; Piredda, S, 1986) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 3.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "The anticonvulsant activity of two competitive antagonists of the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (APH) and 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonate (CPP), and two non-competitive NMDA antagonists, phencyclidine (PCP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801), were compared in 4 models of induced seizures in mice." | 3.67 | A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor. ( Arnolde, SM; Nevins, ME, 1989) |
| "As generation of the two types of seizures is concerned, NMDA and AMPA participate in generalized tonic-clonic seizures whereas NMDA receptors play a dominant role in generation of flexion seizures." | 1.51 | Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats? ( Folbergrová, J; Haugvicová, R; Kubová, H; Mareš, P, 2019) |
| "Seizures were induced by daily administration of 4-aminopyridine (4-AP)." | 1.42 | Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors. ( Borbély, S; Czégé, D; Dobó, E; Mihály, A; Molnár, E; Világi, I, 2015) |
| "The latency to first seizure, the number of seizure episodes and the duration of overt SE, as well as the incidence of deaths was scored with simultaneous electroencephalographic (EEG) recordings." | 1.40 | Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine. ( Czuczwar, M; Kiś, J; Nieoczym, D; Rejdak, K; Turski, WA; Wlaź, P, 2014) |
| "Seizures were induced in 12-day-old rats by bilateral intracerebroventricular infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) and oxidative stress was evaluated by in situ detection of superoxide anion (O(2)·(-))." | 1.38 | Brain superoxide anion formation in immature rats during seizures: protection by selected compounds. ( Druga, R; Folbergrová, J; Otáhal, J, 2012) |
| " A sustained (>20 min) generalized convulsion was induced in Sprague-Dawley juvenile rats by intraperitoneal injection with pentylenetetrazole (PTZ, 70-90 mg/kg) at postnatal day (P) 20." | 1.38 | Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure. ( Mikroulis, AV; Psarropoulou, C, 2012) |
| "Neonatal seizures are associated with a high likelihood of adverse neurological outcomes, including mental retardation, behavioral disorders, and epilepsy." | 1.36 | Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R; Savrasova, A, 2010) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 1.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Seizures were blocked by glutamate receptor antagonists, suggesting that plasticity in excitatory synaptic circuits contributed to seizures." | 1.33 | Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. ( Bausch, SB; He, S; McNamara, JO; Petrova, Y; Wang, XM, 2006) |
| "previously) delayed the onset of EEG seizures and reduced the number of epileptogenic discharges typically observed in rats receiving an injection of gamma-dendrotoxin (35 pmol) alone." | 1.32 | Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat. ( Bagetta, G; Corasaniti, MT; Del Duca, C; Dolly, JO; Morrone, AL; Nappi, G; Palma, E; Piccirilli, S, 2004) |
| "Twenty-four hours following a single seizure episode when there were no behavioral or electrographic seizures, we found enhanced spontaneous activity still present in the rat EC in vivo and in vitro." | 1.32 | Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. ( Anderson, AE; Johnston, D; Leung, V; Lin, X; Shah, MM, 2004) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 1.31 | [Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid]. ( Hivanović, D; Stanojlović, O; Susić, V, 2002) |
| "Diazepam was used as a reference drug." | 1.31 | The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats. ( Chojnacka-Wójcik, E; Przegaliński, E; Tatarczyńska, E, 2000) |
| "One day after the expression of kindled seizures NMDA receptor binding was elevated in striatum, amygdala, hippocampus and frontal cortex." | 1.31 | Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions. ( Itzhak, Y; Martin, JL, 2000) |
| "Within 1 wk of the last kindled seizure, NMDA-dependent charge transfer underlying the perforant path-evoked current was increased by 63-111% at a holding potential of -30 mV." | 1.30 | NMDA-dependent currents in granule cells of the dentate gyrus contribute to induction but not permanence of kindling. ( Rutecki, P; Sutula, T, 1999) |
| "Limbic motor seizures in animals, analogous to complex partial seizures in humans, result in a consistent activation of the mediodorsal thalamus (MD) and, with prolonged seizures, damage to MD." | 1.30 | Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. ( Cassidy, RM; Gale, K, 1998) |
| "Naloxone displayed a seizure-suppressant effect that was delayed and incomplete." | 1.30 | The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors. ( Faingold, CL; N'Gouemo, P, 1999) |
| " Generalized tonic-clonic seizures were at first modified--their tonic phase was restricted to forelimbs, then selectively suppressed--and with increasing dosage the clonic phase was blocked too." | 1.30 | Anticonvulsant action of a NMDA receptor antagonist CGP 40116 varies only quantitatively during ontogeny in rats. ( Haugvicová, R; Mares, P, 1998) |
| "These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary bursts." | 1.30 | Seizure-like events in disinhibited ventral slices of adult rat hippocampus. ( Borck, C; Jefferys, JG, 1999) |
| "MK-801 had no effect on seizure duration." | 1.30 | Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7. ( Braisted, JC; Chavko, M; Harabin, AL, 1998) |
| "Seizures were induced in immature 18-day-old rats by i." | 1.30 | Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats. ( Folbergrová, J, 1997) |
| "The increase in seizure sensitivity of repeatedly withdrawn mice was prevented by treatment with the NMDA receptor antagonist CGP 39551 (20 mg/kg, i." | 1.30 | Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist. ( Dunworth, SJ; Stephens, DN, 1998) |
| "Audiogenic seizures consisted of wild running followed by clonic and tonic convulsions." | 1.30 | APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats. ( Stanojlovic, O; Susic, V; Zivanovic, D, 1997) |
| "Furthermore, seizure latencies after the administration of an ED100 dose of NMDA (150 mg/kg) were significantly higher in antisense treated animals compared to vehicle controls." | 1.30 | Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies. ( Adan, J; Capdevila, JL; Martínez, JM; Piulats, J; Tarrason, G; Trullas, R; Zapata, A, 1997) |
| "GSA potentiated NMDA-induced convulsions significantly, but not L-glutamate- or kainate-induced convulsions." | 1.29 | N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice. ( D'Hooge, R; De Deyn, PP; Pei, YQ, 1993) |
| "4-aminopyridine, particularly the tonic convulsions, but were less effective against those produced by i." | 1.29 | Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine. ( Morales-Villagrán, A; Tapia, R; Ureña-Guerrero, ME, 1996) |
| "5-5 mg/kg, CGP 37849 potentiated the adverse effects but not the anticonvulsant activity of 50 mg/kg valproate." | 1.29 | Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats. ( Hönack, D; Löscher, W, 1993) |
| "The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex." | 1.29 | In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. ( Abe, S; Akazawa, K; Chishaki, A; Goto, Y; Kato, M; Nakamura, M, 1994) |
| " Dose-response curves were evaluated by means of an ethological method in which behavioral sequences typical of S and R animals were quantitated." | 1.29 | NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei. ( Garcia-Cairasco, N; Terra, VC, 1994) |
| " The increased severity of withdrawal, when sufficient time was left for washout of CGP39551, suggests that chronic administration of CGP39551 increased the adaptive changes that cause or contribute to ethanol withdrawal hyperexcitability." | 1.29 | Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist. ( Little, HJ; Ripley, TL, 1995) |
| "Prolonged seizures have long been known to be associated with cell injury and cell death in brain." | 1.29 | The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats. ( Graham, SH; Simon, RP; Tanaka, K, 1996) |
| "At 24 h, kindled seizure was readily activated at the GST." | 1.28 | Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats. ( Mori, N; Wada, JA, 1989) |
| "Tonic-clonic seizures were induced by 225-450 mg/kg Quin." | 1.28 | Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. ( Castiglioni, M; Samanin, R; Stasi, MA; Vezzani, A; Weckermann, B; Wu, HQ, 1989) |
| "The data indicate that seizures evoked from the AT of one hemisphere are susceptible to suppression by inhibition in the SN, but only when the inhibition occurs in the SN of both hemispheres." | 1.28 | Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra. ( Gale, K; Maggio, R, 1989) |
| "Seizures were observed 50 min after injecting Dtx (35 pmol) into the amygdala, though significant neuronal loss was not evident." | 1.28 | Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker. ( Bagetta, G; Dolly, JO; Nisticó, G, 1992) |
| "Moreover, seizure-like activity was induced by removing Mg++ from the medium, a condition that enhances conductance through NMDA receptor-coupled channels." | 1.28 | Synchronized neuronal activities in neocortical explant cultures. ( Baldino, F; Gutnick, MJ; Wolfson, B, 1989) |
| "7CKA did not affect NMDA-induced convulsions but reduced the D-serine potentiation of NMDA responses." | 1.28 | In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site. ( Peeters, BW; Vanderheyden, PM, 1992) |
| "In ethacrynic acid-induced convulsions, these neurotransmitter systems may be differentially modulated, probably through activation of glutaminergic neurons in the brain." | 1.28 | Ethacrynic acid-induced convulsions and brain neurotransmitters in mice. ( Hirose, T; Inagaki, C; Inoue, M; Yasukura, T, 1992) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| "Experimental febrile seizures can be evoked in epileptic chicks by elevation of their body temperature." | 1.28 | Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists. ( Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI, 1990) |
| "Major seizures were significantly suppressed with the highest dose of AP7 (60 mg/kg) in all groups except 7-day-old rats." | 1.28 | Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate. ( Kulovaná, M; Kusá, R; Mares, P; Velísek, L, 1990) |
| "Blockade of these seizures with amino acid antagonists, phosphonocarboxylic acids, was achieved but with a reverse order of potency to that seen with the kindled amygdala." | 1.27 | Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures. ( Bradford, HF; Collins, JF; Peterson, DW, 1984) |
| "Haloperidol pretreatment prevents stereotyped behaviour induced by 2-amino-7-phosphonoheptanoic acid, but does not change the effect on the electroshock test." | 1.27 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra. ( De Sarro, G; Meldrum, BS; Reavill, C, 1984) |
| "Nine convulsions occurred in 29 rats withdrawn from barbital and infused intracerebroventricularly with APH, this contrasted markedly with 61 convulsions seen in 29 animals withdrawn from the drug and infused with saline." | 1.27 | 2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats. ( McCaslin, PP; Morgan, WW, 1987) |
| "Ibotenate-induced seizures and lesions and their specific blockade by a selective antagonist may constitute valuable experimental paradigms for the investigation of seizure disorders." | 1.27 | The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis. ( Aldinio, C; French, ED; Schwarcz, R, 1983) |
| "Clonic seizures were induced in Swiss or DBA/2 mice by methyl-6-7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), 0." | 1.27 | Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents. ( Chapman, AG; Cheetham, SC; Hart, GP; Meldrum, BS; Westerberg, E, 1985) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| "We have used limbic convulsions induced by systemic pilocarpine in rats combined with focal intracerebral injections concurrently to study the initiation and spread of seizure activity." | 1.27 | Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "2APH, 0." | 1.26 | Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid. ( Czuczwar, SJ; Meldrum, B, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (30.92) | 18.7374 |
| 1990's | 70 (46.05) | 18.2507 |
| 2000's | 25 (16.45) | 29.6817 |
| 2010's | 10 (6.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mareš, P | 4 |
| Folbergrová, J | 5 |
| Haugvicová, R | 3 |
| Kubová, H | 1 |
| Rejdak, K | 3 |
| Nieoczym, D | 1 |
| Czuczwar, M | 1 |
| Kiś, J | 1 |
| Wlaź, P | 1 |
| Turski, WA | 7 |
| Borbély, S | 2 |
| Czégé, D | 2 |
| Molnár, E | 2 |
| Dobó, E | 2 |
| Mihály, A | 2 |
| Világi, I | 2 |
| Bakos, M | 1 |
| Szucs, B | 1 |
| Vincze, A | 1 |
| Traub, RD | 1 |
| Duncan, R | 1 |
| Russell, AJ | 1 |
| Baldeweg, T | 1 |
| Tu, Y | 1 |
| Cunningham, MO | 1 |
| Whittington, MA | 1 |
| Carriero, G | 1 |
| Uva, L | 1 |
| Gnatkovsky, V | 1 |
| Avoli, M | 2 |
| de Curtis, M | 1 |
| Isaeva, E | 2 |
| Isaev, D | 2 |
| Savrasova, A | 1 |
| Khazipov, R | 2 |
| Holmes, GL | 3 |
| Prigol, M | 1 |
| Brüning, CA | 1 |
| Nogueira, CW | 1 |
| Zeni, G | 1 |
| Otáhal, J | 1 |
| Druga, R | 1 |
| D'Hooge, R | 3 |
| Van de Vijver, G | 1 |
| Van Bogaert, PP | 2 |
| Marescau, B | 1 |
| Vanholder, R | 1 |
| De Deyn, PP | 3 |
| Bagetta, G | 3 |
| Palma, E | 1 |
| Piccirilli, S | 1 |
| Del Duca, C | 1 |
| Morrone, AL | 1 |
| Nappi, G | 1 |
| Corasaniti, MT | 1 |
| Dolly, JO | 2 |
| Fujiwara-Tsukamoto, Y | 2 |
| Isomura, Y | 2 |
| Kaneda, K | 1 |
| Takada, M | 2 |
| Abdelmalik, PA | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 2 |
| Susić, V | 4 |
| Hivanović, D | 1 |
| Stanojlović, O | 3 |
| Velísek, L | 3 |
| Velísková, J | 2 |
| Giorgi, FS | 1 |
| Moshé, SL | 2 |
| Bausch, SB | 1 |
| He, S | 1 |
| Petrova, Y | 1 |
| Wang, XM | 1 |
| McNamara, JO | 1 |
| Salmani, ME | 1 |
| Mirnajafizadeh, J | 1 |
| Fathollahi, Y | 1 |
| Richichi, C | 1 |
| Brewster, AL | 1 |
| Bender, RA | 1 |
| Simeone, TA | 1 |
| Zha, Q | 1 |
| Yin, HZ | 1 |
| Weiss, JH | 1 |
| Baram, TZ | 1 |
| Voss, LJ | 1 |
| Voss, JM | 1 |
| McLeay, L | 1 |
| Sleigh, JW | 1 |
| Meldrum, BS | 17 |
| Croucher, MJ | 7 |
| Czuczwar, SJ | 10 |
| Collins, JF | 3 |
| Curry, K | 1 |
| Joseph, M | 1 |
| Stone, TW | 2 |
| Badman, G | 1 |
| Jones, AW | 1 |
| Watkins, JC | 2 |
| Turski, L | 3 |
| Schwarz, M | 1 |
| Kleinrok, Z | 8 |
| Wardley-Smith, B | 3 |
| Halsey, MJ | 4 |
| Peterson, DW | 1 |
| Bradford, HF | 5 |
| Meldrum, B | 3 |
| Aldinio, C | 1 |
| French, ED | 1 |
| Schwarcz, R | 1 |
| Perkins, MN | 1 |
| Wardley-Smit, B | 1 |
| Halsey, M | 1 |
| Rostain, JC | 2 |
| De Sarro, G | 3 |
| Reavill, C | 1 |
| Shukla, VK | 2 |
| Lemaire, S | 2 |
| Dumont, M | 1 |
| Merali, Z | 1 |
| Rabbani, M | 2 |
| Wright, EJ | 1 |
| Little, HJ | 3 |
| Ammendola, D | 1 |
| Nava, F | 1 |
| De Sarro, A | 1 |
| Ripley, TL | 1 |
| Shimosaka, S | 1 |
| So, YT | 1 |
| Simon, RP | 2 |
| Pei, YQ | 1 |
| Pearce, PC | 1 |
| Maclean, CJ | 1 |
| Ward, EM | 1 |
| Pearson, J | 1 |
| Henley, M | 1 |
| Stanton, PK | 2 |
| Starr, MS | 2 |
| Starr, BS | 2 |
| Pietrasiewicz, T | 2 |
| Czechowska, G | 2 |
| Dziki, M | 3 |
| Mori, N | 2 |
| Kaura, S | 1 |
| Sunter, DC | 1 |
| Schneiderman, JH | 2 |
| Sterling, CA | 1 |
| Luo, R | 1 |
| Wright, J | 1 |
| Butterworth, AR | 1 |
| Zhou, Q | 1 |
| Springer, JE | 1 |
| Gwag, BJ | 1 |
| Sessler, FM | 1 |
| Terra, VC | 1 |
| Garcia-Cairasco, N | 1 |
| Halonen, T | 1 |
| Tortorella, A | 1 |
| Zrebeet, H | 1 |
| Gale, K | 4 |
| Nakamura, M | 1 |
| Abe, S | 1 |
| Goto, Y | 1 |
| Chishaki, A | 1 |
| Akazawa, K | 1 |
| Kato, M | 1 |
| Cohen, SM | 1 |
| Martin, D | 1 |
| Morrisett, RA | 1 |
| Wilson, WA | 2 |
| Swartzwelder, HS | 1 |
| Löscher, W | 2 |
| Hönack, D | 2 |
| De Sarro, GB | 1 |
| Spagnolo, C | 1 |
| Nisticò, G | 2 |
| Boda, B | 2 |
| Szente, M | 2 |
| Cotterell, KL | 3 |
| Morales-Villagrán, A | 1 |
| Ureña-Guerrero, ME | 1 |
| Tapia, R | 2 |
| Van Den Pol, AN | 1 |
| Obrietan, K | 1 |
| Belousov, A | 1 |
| Tanaka, K | 1 |
| Graham, SH | 1 |
| Zapata, A | 1 |
| Capdevila, JL | 1 |
| Tarrason, G | 1 |
| Adan, J | 1 |
| Martínez, JM | 1 |
| Piulats, J | 1 |
| Trullas, R | 2 |
| Dorandeu, F | 1 |
| Wetherell, J | 1 |
| Pernot-Marino, I | 1 |
| Tattersall, JE | 1 |
| Fosbraey, P | 1 |
| Lallement, G | 1 |
| Zivanovic, D | 3 |
| Dunworth, SJ | 1 |
| Stephens, DN | 1 |
| Pilip, S | 1 |
| Urbanska, EM | 1 |
| Hallak, M | 1 |
| Chavko, M | 1 |
| Braisted, JC | 1 |
| Harabin, AL | 1 |
| Cassidy, RM | 1 |
| Raes, A | 1 |
| Hiramatsu, M | 1 |
| Mori, A | 1 |
| Rutecki, P | 1 |
| Sutula, T | 1 |
| Amabeoku, GJ | 1 |
| N'Gouemo, P | 1 |
| Faingold, CL | 3 |
| Min, MY | 1 |
| Melyan, Z | 1 |
| Kullmann, DM | 1 |
| Borck, C | 1 |
| Jefferys, JG | 1 |
| Velazquez, JL | 1 |
| Itzhak, Y | 1 |
| Martin, JL | 1 |
| Keele, NB | 1 |
| Zinebi, F | 1 |
| Neugebauer, V | 1 |
| Shinnick-Gallagher, P | 1 |
| Przegaliński, E | 1 |
| Tatarczyńska, E | 1 |
| Chojnacka-Wójcik, E | 1 |
| Rejdak, R | 2 |
| Stelmasiak, Z | 1 |
| Sieklucka-Dziuba, M | 2 |
| Manjarrez, J | 1 |
| Alvarado, R | 1 |
| Camacho-Arroyo, I | 1 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Xiong, ZQ | 1 |
| Stringer, JL | 1 |
| Liptáková, S | 1 |
| Hussain, S | 1 |
| Holmes, KH | 2 |
| Bilkey, DK | 2 |
| Laverty, R | 2 |
| Peeters, BW | 1 |
| Vanderheyden, PM | 1 |
| Engelsen, BA | 1 |
| Fonnum, F | 1 |
| Furset, K | 1 |
| Inoue, M | 1 |
| Hirose, T | 1 |
| Yasukura, T | 1 |
| Inagaki, C | 1 |
| Ferkany, JW | 1 |
| Kyle, DJ | 1 |
| Ellenberger, WP | 1 |
| Narayanan, BA | 1 |
| Ellenberger, SR | 1 |
| Hudkins, R | 1 |
| Guzewska, ME | 1 |
| Rzeszotarski, WJ | 1 |
| Conti, L | 1 |
| Patch, R | 1 |
| Fragoso-Veloz, J | 1 |
| Skolnick, P | 1 |
| Miller, R | 1 |
| Young, A | 1 |
| Boje, K | 1 |
| Xie, XH | 1 |
| Tietz, EI | 1 |
| Rosenberg, HC | 1 |
| Liljequist, S | 1 |
| Goddard, GV | 1 |
| Tancredi, V | 1 |
| Hwa, GG | 1 |
| Zona, C | 1 |
| Brancati, A | 1 |
| Koroshetz, WJ | 1 |
| Furshpan, EJ | 1 |
| Chiamulera, C | 1 |
| Costa, S | 1 |
| Reggiani, A | 1 |
| Daló, NL | 1 |
| Piña, JC | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
| Thompson, JL | 1 |
| Carl, GF | 1 |
| Gallagher, BS | 1 |
| Hoy, J | 1 |
| McLaughlin, M | 1 |
| Kusá, R | 1 |
| Kulovaná, M | 1 |
| Wada, JA | 1 |
| Vezzani, A | 3 |
| Stasi, MA | 2 |
| Wu, HQ | 3 |
| Castiglioni, M | 1 |
| Weckermann, B | 1 |
| Samanin, R | 3 |
| Millan, MH | 7 |
| Nevins, ME | 1 |
| Arnolde, SM | 1 |
| Traynelis, SF | 1 |
| Dingledine, R | 1 |
| Pierson, MG | 1 |
| Smith, KL | 1 |
| Swann, JW | 1 |
| Gutnick, MJ | 1 |
| Wolfson, B | 1 |
| Baldino, F | 1 |
| Maggio, R | 1 |
| Stasheff, SF | 1 |
| Anderson, WW | 1 |
| Clark, S | 1 |
| McCaslin, PP | 1 |
| Morgan, WW | 1 |
| Janusz, W | 1 |
| Wamil, A | 1 |
| Moneta, E | 1 |
| Patel, S | 5 |
| Chapman, AG | 2 |
| Cheetham, SC | 1 |
| Hart, GP | 1 |
| Westerberg, E | 1 |
| Colton, CA | 1 |
| Colton, JS | 1 |
| Cavalheiro, EA | 2 |
| Frenk, H | 1 |
| Liban, A | 1 |
| Urca, G | 1 |
| Teichberg, VI | 1 |
| MacDonald, JF | 1 |
| Dewhurst, DG | 1 |
| Cain, DP | 1 |
| Desborough, KA | 1 |
| McKitrick, DJ | 1 |
| Wong, BY | 1 |
| Coulter, DA | 1 |
| Choi, DW | 1 |
| Prince, DA | 1 |
| Lason, W | 1 |
| Simpson, JN | 1 |
| McGinty, JF | 1 |
| Larson, AA | 1 |
| Beitz, AJ | 1 |
| Jones, RS | 1 |
| Mody, I | 1 |
| Heinemann, U | 1 |
| Angelico, P | 1 |
| Mello, LM | 2 |
| Millan, M | 1 |
| Engelsen, B | 1 |
| Boersma, CA | 2 |
| Zaczek, R | 1 |
| Markl, A | 1 |
| Balm, M | 1 |
| Coyle, JT | 1 |
| Piredda, S | 1 |
| Treviño, M | 1 |
| Vivar, C | 1 |
| Gutiérrez, R | 1 |
| Mikroulis, AV | 1 |
| Psarropoulou, C | 1 |
| Nambu, A | 1 |
| Lovic, OS | 1 |
| Shah, MM | 1 |
| Anderson, AE | 1 |
| Leung, V | 1 |
| Lin, X | 1 |
| Johnston, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Seizure Detection in Neonates Using Multimodal Temporary Epidermal Electronics[NCT02451618] | 13 participants (Actual) | Observational | 2015-01-27 | Terminated (stopped due to Trial was discontinued due to inadequate signal from study eeg leads.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for 2-amino-5-phosphonovalerate and Seizures
| Article | Year |
|---|---|
Roles of excitatory amino acids in expression of secondarily generalized limbic seizures: observations in the kindling model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dimethyl Sulfoxide; Electric Stimulation; Gluta | 1993 |
Effect of parenteral magnesium sulfate administration on excitatory amino acid receptors in the rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Blood-Brain Barrier; Hippocampus; Infusions, | 1998 |
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
149 other studies available for 2-amino-5-phosphonovalerate and Seizures
| Article | Year |
|---|---|
Do stereoisomers of homocysteic acid exhibit different convulsant action in immature rats?
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzodiazepines; Dizocilpine Maleate; Homocysteine; Male; Quin | 2019 |
Orphenadrine-induced convulsive status epilepticus in rats responds to the NMDA antagonist dizocilpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electroencephalography; | 2014 |
Repeated application of 4-aminopyridine provoke an increase in entorhinal cortex excitability and rearrange AMPA and kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Benzodiazepines; Entorhinal Cortex; Excitator | 2015 |
Modification of ionotropic glutamate receptor-mediated processes in the rat hippocampus following repeated, brief seizures.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Animals; Benzodiazepines; Biophysic | 2009 |
Spatiotemporal patterns of electrocorticographic very fast oscillations (> 80 Hz) consistent with a network model based on electrical coupling between principal neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auto | 2010 |
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Ep | 2010 |
Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Ex | 2010 |
The role of the glutathione system in seizures induced by diphenyl diselenide in rat pups.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzene Derivatives; Buthionine Sulfoximine; | 2011 |
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2012 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium Cha | 2003 |
Involvement of a glutamergic mechanism in gamma-dendrotoxin-induced hippocampal neuronal cell loss in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Elapid Venoms; Electroenceph | 2004 |
Synaptic interactions between pyramidal cells and interneurone subtypes during seizure-like activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; El | 2004 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 2005 |
[Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid].
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Male; Phencyclidine; Rats; Rats, Wistar; Seiz | 2002 |
Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development.
Topics: 2-Amino-5-phosphonovalerate; Acrylates; Age Factors; Analysis of Variance; Animals; Animals, Newborn | 2006 |
Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Epilepsy, Temporal Lobe | 2006 |
Offsetting of aberrations associated with seizure proneness in rat hippocampus area CA1 by theta pulse stimulation-induced activity pattern.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Convulsants; Dat | 2007 |
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Cal | 2008 |
Aconitine induces prolonged seizure-like events in rat neocortical brain slices.
Topics: 2-Amino-5-phosphonovalerate; Aconitine; Action Potentials; Animals; Calcium; Central Nervous System | 2008 |
A comparison of the anticonvulsant potency of (+/-) 2-amino-5-phosphonopentanoic acid and (+/-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1983 |
Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon, Papio papio.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Glutamates; Papio; Photic Stimul | 1983 |
Suppression of audiogenic seizures in DBA/2 mice by two new dipeptide NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Aspartic A | 1984 |
Effects of excitatory amino-acid antagonists on the anticonvulsant action of phenobarbital or diphenylhydantoin in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anticonvulsants; Drug Interac | 1984 |
The high pressure neurological syndrome and 2-amino-7-phosphonoheptanoic acid: differences between fed and fasted rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Brain; Fasti | 1984 |
Anticonvulsant action of amino acid antagonists against kindled hippocampal seizures.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Animals; Anticonvulsants; Cerebral Ventric | 1984 |
Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Kain | 1982 |
The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Behavior, Animal; Dose-Response Relationship, Dru | 1983 |
On the interaction of 2-amino-7-phosphono-heptanoic acid and quinolinic acid in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Electrophysiology; Iontophoresis; | 1983 |
2-Amino-phosphonoheptanoic acid protects against the high pressure neurological syndrome.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsies, Myoclonic; Male | 1983 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Caudate Nucleus; Electroshock; Haloperidol; Hippo | 1984 |
Norbinaltorphimine protection against N-methyl-D-aspartic acid-induced convulsions and mortality.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bicu | 1993 |
N-methyl-D-aspartate receptor antagonist activity and phencyclidine-like behavioral effects of the pentadecapeptide, [Ser1]histogranin.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Sequence; Animals; Anticonvulsants; Behavior, Animal; Bindin | 1995 |
Tolerance to competitive NMDA antagonists, but no crosstolerance with barbiturates.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ataxia; Behavior, Animal; Dizocilpine Maleate; Drug Tolerance; | 1995 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvuls | 1995 |
Effects on ethanol withdrawal hyperexcitability of chronic treatment with a competitive N-methyl-D-aspartate receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Drug Administration Schedule; Ethanol; Handling, Psychological | 1995 |
Deep prepiriform cortex modulates kainate-induced hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; El | 1994 |
NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Animals, Newborn; Anticonvulsants; Dizocilpine Ma | 1994 |
N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Interactions; Female; Glutamates; Glutam | 1993 |
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Anticonvulsants; Electroencephalography; | 1993 |
Age dependence of homosynaptic non-NMDA mediated long-term depression in field CA1 of rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Electric Stimulation; Evoked Potentials; Hippocampus; I | 1993 |
The new competitive NMDA receptor antagonist CGP 40116 inhibits pilocarpine-induced limbic motor seizures and unconditioned motor behaviour in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Grooming; Limbic System; Locomotion; Male | 1994 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Di | 1993 |
Competitive NMDA receptor antagonists enhance the antielectroshock activity of various antiepileptics.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Carbama | 1993 |
Relative anticonvulsant potencies of CPP and some novel analogues in the kindled rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Kindling, Neurologic; Male; Piperazines; Rats | 1993 |
Hippocampal plasticity following epileptiform bursting produced by GABAA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Evoked Potentials; GABA Antago | 1994 |
Possible involvement of NMDA receptor-mediated transmission in barbiturate physical dependence.
Topics: 2-Amino-5-phosphonovalerate; Animals; Barbital; Bicuculline; Cerebral Cortex; Dizocilpine Maleate; H | 1994 |
Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain-Derived Neurotroph | 1994 |
NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Brain Mapp | 1994 |
Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Entorhinal Cort | 1994 |
In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Body Weight; Dizocilpine Maleate | 1994 |
Proconvulsant and anticonvulsant properties of ethanol: studies of electrographic seizures in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug | 1993 |
Competitive antagonists of NMDA receptors, CGP 37849 and CGP 39551, enhance the anticonvulsant activity of valproate against electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, | 1993 |
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Ataxia; Female; Kindling, Neurologi | 1993 |
Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Mal | 1993 |
Nitric oxide synthase inhibitor facilitates focal seizures induced by aminopyridine in rat.
Topics: 2-Amino-5-phosphonovalerate; Aminopyridines; Animals; Arginine; Cerebral Ventricles; Drug Synergism; | 1996 |
Characterisation of N-methyl-D-aspartate (NMDA)-induced kindling.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Anticonvulsants; Electroencephalography | 1996 |
Protection by NMDA receptor antagonists against seizures induced by intracerebral administration of 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anticonvulsants; Convulsants; Dizocilpine Mal | 1996 |
Glutamate hyperexcitability and seizure-like activity throughout the brain and spinal cord upon relief from chronic glutamate receptor blockade in culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Cadmium; Calcium; | 1996 |
The role of excitatory neurotransmitters in seizure-induced neuronal injury in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood Pressure; Cerebral Cortex; | 1996 |
Effects of NMDA-R1 antisense oligodeoxynucleotide administration: behavioral and radioligand binding studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Behavior, Animal; Brain; Excitatory Amino | 1997 |
Nitric oxide synthase inhibitor facilitates aminopyridine induced neocortical seizure.
Topics: 2-Amino-5-phosphonovalerate; Aminopyridines; Animals; Cerebral Cortex; Electroencephalography; Nitri | 1996 |
Effects of excitatory amino acid antagonists on dendrotoxin-induced increases in neurotransmitter release and epileptiform bursting in rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 1997 |
Anticonvulsant action of both NMDA and non-NMDA receptor antagonists against seizures induced by homocysteine in immature rats.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Anticonvulsants; Behavior, Animal; Brain Chemistr | 1997 |
APH, an N-methyl-D-aspartate receptor antagonist, blocks the metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Convulsants; Electroenc | 1997 |
Sensitisation to repeated withdrawal, in mice treated chronically with diazepam, is blocked by an NMDA receptor antagonist.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Convulsants; Diazepam; Excitatory Amino A | 1998 |
Chlormethiazole anticonvulsive efficacy diminished by N-methyl-D-aspartate but not kainate in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Chlormethiazole; Electroshock; Excitatory Ami | 1998 |
Effect of MK-801 on seizures induced by exposure to hyperbaric oxygen: comparison with AP-7.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Cerebral Cortex; Cerebr | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisoto | 1998 |
Anticonvulsant action of a NMDA receptor antagonist CGP 40116 varies only quantitatively during ontogeny in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Rats; Recep | 1998 |
The anticonvulsant potency of (+/-)-2-Amino-7-phosphonoheptanoic acid and (+/-)-2-amino-5-phosphonovaleric acid against metaphit-induced audiogenic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid A | 1998 |
Effects of the competitive N-methyl-D-aspartate antagonist CGP 37849 and its ethylester CGP 39551 on N-methyl-D-aspartate-evoked whole-cell currents in cultured spinal neurones and on vestibular stimulation-induced seizures in EL mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Avoidance Learning; Cells, Cultured; Electric | 1998 |
NMDA-dependent currents in granule cells of the dentate gyrus contribute to induction but not permanence of kindling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Electric Stimulation; Evoked Potentials; Excita | 1999 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cl | 1999 |
The periaqueductal grey is a critical site in the neuronal network for audiogenic seizures: modulation by GABA(A), NMDA and opioid receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagoni | 1999 |
Synaptically released glutamate reduces gamma-aminobutyric acid (GABA)ergic inhibition in the hippocampus via kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; GABA-B | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials | 1999 |
Synchronization of GABAergic interneuronal networks during seizure-like activity in the rat horizontal hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Elect | 1999 |
Cocaine-induced kindling is associated with elevated NMDA receptor binding in discrete mouse brain regions.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Brain; Cocaine; Corpus Striatum; Dose-Response Relat | 2000 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Epileptogenesis up-regulates metabotropic glutamate receptor activation of sodium-calcium exchange current in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Calcium; Dose- | 2000 |
The influence of the benzodiazepine receptor antagonist flumazenil on the anxiolytic-like effects of CGP 37849 and ACPC in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anti-Anxiety Agents; Conflic | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Car | 2000 |
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; D | 2000 |
Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizo | 2001 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Prolonged bursts occur in normal calcium in hippocampal slices after raising excitability and blocking synaptic transmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Calcium; Co | 2001 |
The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Dose-Response Relationship, Drug; Excitatory Amin | 2001 |
Weak anticonvulsant activity of CGP 37849 and CGP 39551 against kindled seizures following systemic administration.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intr | 1992 |
The infusion of an NMDA antagonist into perirhinal cortex suppresses amygdala-kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cerebral Cortex; Injections; Kindling, Neurologic; M | 1992 |
Competitive NMDA receptor antagonists raise electrically kindled generalized seizure thresholds.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Binding, Competitive; Electric Stim | 1992 |
In vitro and in vivo characterization of the NMDA receptor-linked strychnine-insensitive glycine site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Dizocilpine Maleate; Glycine; Kynurenic Acid | 1992 |
Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Diseases; Dizocilpine Maleate; Elapid Venoms; Electroenc | 1992 |
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amino Acids; Animals; Anticonvulsants; Brain Mapping; Caudate | 1992 |
Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Synergism; Female; Kindling, Neurolo | 1992 |
Ethacrynic acid-induced convulsions and brain neurotransmitters in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Brain; Chloride Channels; Ethacrynic Acid; gamm | 1992 |
Pharmacological profile of novel cyclic analogs of 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Brain; Dose-Response Relationshi | 1992 |
NMDA receptor antagonists protect against seizures and wet-dog shakes induced by 4-aminopyridine.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acids; Animals; Behavior, Animal; Male; N-Methyl | 1992 |
Chronic treatment with 1-aminocyclopropanecarboxylic acid desensitizes behavioral responses to compounds acting at the N-methyl-D-aspartate receptor complex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amino Acids, Cyclic; Animals; Anticonvulsants; Antidepress | 1992 |
Anti-pentylenetetrazol effect of intranigral 2-amino-7-phosphonoheptanoate attenuated by muscimol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Drug Combinations; Male; Muscimo | 1991 |
The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Diet; Dizocilpine Maleate; Ethanol; Hippocampus; Mice; Mice, I | 1991 |
The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Kindling, Neurologic; Male; | 1990 |
Low magnesium epileptogenesis in the rat hippocampal slice: electrophysiological and pharmacological features.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; gamma-Aminobutyric Acid; Hippocampus; In Vitro Te | 1990 |
Seizure-like activity and glutamate receptors in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Electro | 1990 |
Effect of NMDA- and strychnine-insensitive glycine site antagonists on NMDA-mediated convulsions and learning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Injections, Intraventricular; Kynurenic A | 1990 |
Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bufo marinus; Cold Temperature; Kynurenic Acid; Muscle Contrac | 1990 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid | 1990 |
Effect of 2-amino-7-phosphonoheptanoic acid (APH) on seizure susceptibility in the prepubescent and mature rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Injections, Intraventricular; Kindling, Neurologi | 1990 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. I. The effects of 2-amino-7-phosphonoheptanoate.
Topics: 2-Amino-5-phosphonovalerate; Aging; Amino Acids; Animals; Anticonvulsants; Male; Motor Activity; Pen | 1990 |
Suppression of amygdaloid kindled convulsion following unilateral injection of 2-amino-7-phosphonoheptanoic acid (2-APH) into the substantia innominata of rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Amygdala; Animals; Basal Ganglia; Male; Rats; Receptors, N | 1989 |
Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood-Brain Barrier; Cerebral Co | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; G | 1989 |
A comparison of the anticonvulsant effects of competitive and non-competitive antagonists of the N-methyl-D-aspartate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Dibenzocycloheptenes; Dizocilpin | 1989 |
Modification of potassium-induced interictal bursts and electrographic seizures by divalent cations.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Hippocampus; In Vitro Techniques; Magnesium; Potassiu | 1989 |
A slow NMDA-mediated synaptic potential underlies seizures originating from midbrain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Bicuculline; In Vitro Techniques; Inferior Coll | 1989 |
Synchronized neuronal activities in neocortical explant cultures.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Magnesium; Me | 1989 |
Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Glutamates; Male; Morphine; Musc | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
2-Amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate, prevents barbital withdrawal-induced convulsions and the elevation of cerebellar cyclic GMP in dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Barbital; Barbiturates; Cerebellum | 1987 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Role of the N-methyl-D-aspartate-type receptors in the development and maintenance of hippocampal kindling in rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Electric Stimulation; Hippocam | 1988 |
Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Injections; Limbic System; Male; | 1988 |
Effects of two convulsant beta-carboline derivatives, DMCM and beta-CCM, on regional neurotransmitter amino acid levels and on in vitro D-[3H]aspartate release in rodents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain Chemistry; Carbolines; Cereb | 1985 |
Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anticonvulsants; Glutamates; | 1985 |
Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; El | 1985 |
Absence of side-effects in the anticonvulsant action of cortically applied antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dipeptides; Morphine; N-Methyl | 1986 |
Effects of reduced magnesium on hippocampal synchrony.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Electrophysiology; Guinea Pigs; Hippocampus; In V | 1987 |
Possible role of excitatory amino acids in the convulsant action of catechol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Catechols; Dibenzocycloheptenes; Dipeptides; Dizo | 1988 |
Retardation of amygdala kindling by antagonism of NMD-aspartate and muscarinic cholinergic receptors: evidence for the summation of excitatory mechanisms in kindling.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Kindling, Neurologic; Male; Rats; Receptors, Muscari | 1988 |
Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antitussive Agents; Aspartic Acid; Cerebral C | 1988 |
Effects of D-(-)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Injections, Intraperitoneal; Kainic Acid; Male; R | 1988 |
Glycine potentiates strychnine-induced convulsions: role of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Drug Synergism; Glycine; Injections, Spinal; Mi | 1988 |
Epileptiform activity induced by lowering extracellular [Mg2+] in combined hippocampal-entorhinal cortex slices: modulation by receptors for norepinephrine and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cerebral Cortex; Electric Stimulation; Hipp | 1987 |
Quinolinic acid-induced seizures, but not nerve cell death, are associated with extracellular Ca2+ decrease assessed in the hippocampus by brain dialysis.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Calcium; Dialysis; Dose-Response Relationship, Dr | 1988 |
2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Male; Muscimol; N | 1986 |
Excitatory neurotransmission within substantia nigra pars reticulata regulates threshold for seizures produced by pilocarpine in rats: effects of intranigral 2-amino-7-phosphonoheptanoate and N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Electroencephalog | 1986 |
Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Cerebellum; Limbic System; Male; M | 1987 |
2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Blood Glucose; Brain Chemistry; Ce | 1987 |
Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. I. Afferent seizure initiation pathway.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Afferent Pathways; Amino Acids; Animals; Genicula | 1988 |
Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Efferent Pathways; Female; | 1988 |
A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Convulsants; Diaz | 1986 |
Effect of 2-aminophosphonoheptanoic acid on the EEG of rats exposed to high pressure.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Central Nervous System Dise | 1986 |
Focal injection of 2-amino-7-phosphonoheptanoic acid into prepiriform cortex protects against pilocarpine-induced limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Limbic System; Male; Pilocarpine | 1986 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Ma | 1986 |
Excitation-inhibition balance in the CA3 network--neuronal specificity and activity-dependent plasticity.
Topics: Animals; CA3 Region, Hippocampal; Convulsants; Electric Stimulation; Electrophysiology; Excitatory A | 2011 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Dise | 2012 |
Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetazolamide; Animals; Animals, Newborn; Anti-Ulcer Agents; A | 2003 |
Effects of manipulation of N-methyl-D-aspartate receptors on imipenem/cilastatin-induced seizures in rats.
Topics: Acetamides; Animals; Binding Sites; Cilastatin; Cilastatin, Imipenem Drug Combination; Drug Combinat | 2004 |
Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons.
Topics: Analysis of Variance; Animals; Bicuculline; Blotting, Western; Cyclic Nucleotide-Gated Cation Channe | 2004 |