2-amino-5-phosphonovalerate has been researched along with Schizophrenia in 9 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Latusz, J | 1 |
| Maćkowiak, M | 3 |
| Scarr, E | 1 |
| Beneyto, M | 2 |
| Meador-Woodruff, JH | 2 |
| Dean, B | 1 |
| Wedzony, K | 3 |
| Fijał, K | 2 |
| Chocyk, A | 2 |
| Kristiansen, LV | 1 |
| Oni-Orisan, A | 1 |
| McCullumsmith, RE | 1 |
| Fijal, K | 1 |
| Zajaczkowski, W | 1 |
| Grimwood, S | 1 |
| Slater, P | 1 |
| Deakin, JF | 1 |
| Hutson, PH | 1 |
| Javitt, DC | 1 |
| Jotkowitz, A | 1 |
| Sircar, R | 1 |
| Zukin, SR | 1 |
| Fujihara, K | 1 |
| Miwa, H | 1 |
| Kakizaki, T | 1 |
| Kaneko, R | 1 |
| Mikuni, M | 1 |
| Tanahira, C | 1 |
| Tamamaki, N | 1 |
| Yanagawa, Y | 1 |
9 other studies available for 2-amino-5-phosphonovalerate and Schizophrenia
| Article | Year |
|---|---|
Early-life blockade of NMDA receptors induces epigenetic abnormalities in the adult medial prefrontal cortex: possible involvement in memory impairment in trace fear conditioning.
Topics: 2-Amino-5-phosphonovalerate; Acetylation; Animals; Behavior, Animal; Conditioning, Psychological; Ep | 2020 |
Cortical glutamatergic markers in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 2005 |
Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Axons; Excitatory Amino Acid Antagonists; Female; | 2005 |
Alterations in the dendritic morphology of prefrontal pyramidal neurons in adult rats after blockade of NMDA receptors in the postnatal period.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Cell Count; Dendrites; Disease Models, Anima | 2005 |
Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders.
Topics: 2-Amino-5-phosphonovalerate; Adult; Analysis of Variance; Autoradiography; Excitatory Amino Acid Ant | 2007 |
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, | 2008 |
NR2B-containing NMDA receptors are up-regulated in temporal cortex in schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Aminoquinolines; Binding Sites; Cadaver; Excitatory Amino Acid Antagoni | 1999 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; | 1987 |
Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Actins; Action Potentials; Animals; Dendrites; Disease Models, | 2015 |