2-amino-5-phosphonovalerate has been researched along with Recrudescence in 6 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neonatal seizures are associated with a high likelihood of adverse neurological outcomes, including mental retardation, behavioral disorders, and epilepsy." | 1.36 | Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. ( Holmes, GL; Isaev, D; Isaeva, E; Khazipov, R; Savrasova, A, 2010) |
| "Raclopride alone was without effect on either test day." | 1.31 | Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior. ( Grimm, JW; Kruzich, PJ; See, RE, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Isaeva, E | 1 |
| Isaev, D | 1 |
| Savrasova, A | 1 |
| Khazipov, R | 1 |
| Holmes, GL | 1 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 1 |
| Zhang, L | 1 |
| Carlen, PL | 1 |
| Famous, KR | 1 |
| Schmidt, HD | 1 |
| Pierce, RC | 1 |
| Cornish, JL | 1 |
| Duffy, P | 1 |
| Kalivas, PW | 1 |
| Shors, TJ | 1 |
| See, RE | 1 |
| Kruzich, PJ | 1 |
| Grimm, JW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Seizure Detection in Neonates Using Multimodal Temporary Epidermal Electronics[NCT02451618] | 13 participants (Actual) | Observational | 2015-01-27 | Terminated (stopped due to Trial was discontinued due to inadequate signal from study eeg leads.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 other studies available for 2-amino-5-phosphonovalerate and Recrudescence
| Article | Year |
|---|---|
Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Ex | 2010 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors | 2007 |
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1999 |
Acute stress and re-exposure to the stressful context suppress spontaneous unit activity in the basolateral amygdala via NMDA receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Acute Disease; Amygdala; Animals; Excitatory Amino Acid Antagonists; Ma | 1999 |
Dopamine, but not glutamate, receptor blockade in the basolateral amygdala attenuates conditioned reward in a rat model of relapse to cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Behavior, Addi | 2001 |