2-amino-5-phosphonovalerate has been researched along with Peripheral Nerve Injury in 4 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 7.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 3.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tolou-Dabbaghian, B | 1 |
| Delphi, L | 1 |
| Rezayof, A | 1 |
| Hama, AT | 1 |
| Unnerstall, JR | 1 |
| Siegan, JB | 1 |
| Sagen, J | 1 |
| Leem, JW | 1 |
| Choi, EJ | 1 |
| Park, ES | 1 |
| Paik, KS | 1 |
| Seltzer, Z | 1 |
| Cohn, S | 1 |
| Ginzburg, R | 1 |
| Beilin, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenomics and Genomics of Clinically Relevant Chronic Postsurgical Pain: A Multicenter Prospective Study[NCT04798573] | 10,000 participants (Anticipated) | Observational | 2012-08-03 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for 2-amino-5-phosphonovalerate and Peripheral Nerve Injury
| Article | Year |
|---|---|
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme | 2019 |
Modulation of NMDA receptor expression in the rat spinal cord by peripheral nerve injury and adrenal medullary grafting.
Topics: 2-Amino-5-phosphonovalerate; Adrenal Medulla; Animals; Excitatory Amino Acid Antagonists; Immunohist | 1995 |
N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptor antagonists differentially suppress dorsal horn neuron responses to mechanical stimuli in rats with peripheral nerve injury.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Elec | 1996 |
Modulation of neuropathic pain behavior in rats by spinal disinhibition and NMDA receptor blockade of injury discharge.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Dizocilpine Maleate; Electric Stimulation; G | 1991 |