2-amino-5-phosphonovalerate has been researched along with Parkinsonian Disorders in 3 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharya, S | 1 |
| Ma, Y | 1 |
| Dunn, AR | 1 |
| Bradner, JM | 1 |
| Scimemi, A | 1 |
| Miller, GW | 1 |
| Traynelis, SF | 1 |
| Wichmann, T | 1 |
| Morin, N | 1 |
| Morissette, M | 1 |
| Grégoire, L | 1 |
| Gomez-Mancilla, B | 1 |
| Gasparini, F | 1 |
| Di Paolo, T | 1 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
3 other studies available for 2-amino-5-phosphonovalerate and Parkinsonian Disorders
| Article | Year |
|---|---|
NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-Amino-5-phosphonovalerate; Action Potentials; Animal | 2018 |
Chronic treatment with MPEP, an mGlu5 receptor antagonist, normalizes basal ganglia glutamate neurotransmission in L-DOPA-treated parkinsonian monkeys.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Corpus Striatum; Dyskinesia, Drug- | 2013 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |