2-amino-5-phosphonovalerate has been researched along with Neurogenic Inflammation in 2 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Neurogenic Inflammation: Inflammation caused by an injurious stimulus of peripheral neurons and resulting in release of neuropeptides which affect vascular permeability and help initiate proinflammatory and immune reactions at the site of injury.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At early time points, NMDA receptor and NGC activation enhance descending facilitation; as time progresses, the dose-response curve of NMDA shifts to the left and descending inhibition dominates and masks any descending facilitation." | 1.31 | The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation. ( Dubner, R; Ren, K; Terayama, R, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terayama, R | 1 |
| Dubner, R | 1 |
| Ren, K | 1 |
| Warsame Afrah, A | 1 |
| Gustafsson, H | 1 |
| Olgart, L | 1 |
| Brodin, E | 1 |
| Stiller, CO | 1 |
| Taylor, BK | 1 |
2 other studies available for 2-amino-5-phosphonovalerate and Neurogenic Inflammation
| Article | Year |
|---|---|
The roles of NMDA receptor activation and nucleus reticularis gigantocellularis in the time-dependent changes in descending inhibition after inflammation.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Electric Stimulation; Excitatory Amino Acid Agonis | 2002 |
Capsaicin-evoked substance P release in rat dorsal horn increases after peripheral inflammation: a microdialysis study.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agoni | 2004 |