2-amino-5-phosphonovalerate has been researched along with Nervous System Disorders in 9 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation." | 7.68 | The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992) |
| "The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation." | 3.68 | The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992) |
| "It was found that, following middle cerebral artery occlusion (MCAO), PSD-93 knockout (KO) mice manifested significant reductions in infarcted volume, neurological deficits and number of degenerated neurons." | 1.40 | PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia. ( Chen, L; Chen, X; Li, J; Li, Q; Shao, Y; Xu, Y; Zhang, M; Zhang, Q; Zhang, X, 2014) |
| " The neurotoxicity induced by carbamazepine may be involved in the teratogenic and adverse effects of overdose associated with the treatment of manic-depressive illness and seizures." | 1.28 | Carbamazepine-induced neurotoxicity and its prevention by NMDA in cultured cerebellar granule cells. ( Chuang, DM; Gao, XM, 1992) |
| "Tonic-clonic seizures were induced by 225-450 mg/kg Quin." | 1.28 | Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability. ( Castiglioni, M; Samanin, R; Stasi, MA; Vezzani, A; Weckermann, B; Wu, HQ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Flavin, MP | 1 |
| Radek, RJ | 1 |
| Giardina, WJ | 1 |
| Gao, XM | 1 |
| Chuang, DM | 1 |
| Takadera, T | 1 |
| Suzuki, R | 1 |
| Mohri, T | 1 |
| Millan, MH | 2 |
| Wardley-Smith, B | 2 |
| Dürmüller, N | 1 |
| Meldrum, BS | 2 |
| Vezzani, A | 1 |
| Stasi, MA | 1 |
| Wu, HQ | 1 |
| Castiglioni, M | 1 |
| Weckermann, B | 1 |
| Samanin, R | 1 |
| Halsey, MJ | 1 |
| Shinozaki, H | 1 |
| Zhang, M | 1 |
| Li, Q | 1 |
| Chen, L | 1 |
| Li, J | 1 |
| Zhang, X | 1 |
| Chen, X | 1 |
| Zhang, Q | 1 |
| Shao, Y | 1 |
| Xu, Y | 1 |
1 review available for 2-amino-5-phosphonovalerate and Nervous System Disorders
| Article | Year |
|---|---|
Pharmacology of the glutamate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Antidepressive Agents; Azepines; | 1988 |
8 other studies available for 2-amino-5-phosphonovalerate and Nervous System Disorders
| Article | Year |
|---|---|
Influence of dexamethasone on neurotoxicity caused by oxygen and glucose deprivation in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Death; Cell Hypoxia | 1996 |
The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cold Temperature; Dextromethorphan; Guinea Pigs; Hippocampus; | 1992 |
Carbamazepine-induced neurotoxicity and its prevention by NMDA in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Carbamazepine; Cells, Cultured; Cerebell | 1992 |
Protection by ethanol of cortical neurons from N-methyl-D-aspartate-induced neurotoxicity is associated with blocking calcium influx.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Channel Blockers; Cell Survival; Cells, Cultu | 1990 |
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsy; Female; Male; Myo | 1991 |
Studies on the potential neurotoxic and convulsant effects of increased blood levels of quinolinic acid in rats with altered blood-brain barrier permeability.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Blood-Brain Barrier; Cerebral Co | 1989 |
Studies on the role of the NMDA receptor in the substantia nigra pars reticulata and entopeduncular nucleus in the development of the high pressure neurological syndrome in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Atmospheric Pressure; Catalepsy; G | 1989 |
PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Disks Large Homolo | 2014 |