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2-amino-5-phosphonovalerate and Nerve Pain

2-amino-5-phosphonovalerate has been researched along with Nerve Pain in 5 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
"The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia."7.91Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019)
"The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia."3.91Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019)
"In paclitaxel-treated rats, the baseline frequency of miniature EPSCs (mEPSCs) was significantly increased; the NMDAR antagonist 2-amino-5-phosphonopentanoic acid (AP5) completely normalized this frequency."1.43Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain. ( Chen, H; Chen, SR; Pan, HL; Xie, JD; Zeng, WA, 2016)
"Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood."1.38Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. ( Barres, B; Boroujerdi, A; Corpe, M; Deng, P; Eroglu, C; Kim, DS; Lee, J; Li, KW; Luo, ZD; Park, J; Peter Yu, Y; Sharp, K; Steward, O; Xu, ZC; Zaucke, F; Zhang, X; Zhou, CY, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tolou-Dabbaghian, B1
Delphi, L1
Rezayof, A1
Xie, JD1
Chen, SR1
Chen, H1
Zeng, WA1
Pan, HL1
Sorkin, LS1
Puig, S1
Jones, DL1
Kelly, CJ1
Martina, M1
Kim, DS1
Li, KW1
Boroujerdi, A1
Peter Yu, Y1
Zhou, CY1
Deng, P1
Park, J1
Zhang, X1
Lee, J1
Corpe, M1
Sharp, K1
Steward, O1
Eroglu, C1
Barres, B1
Zaucke, F1
Xu, ZC1
Luo, ZD1

Other Studies

5 other studies available for 2-amino-5-phosphonovalerate and Nerve Pain

ArticleYear
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
    The journal of pain, 2019, Volume: 20, Issue:8

    Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme

2019
Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain.
    The Journal of biological chemistry, 2016, 09-09, Volume: 291, Issue:37

    Topics: 2-Amino-5-phosphonovalerate; Animals; Ganglia, Spinal; Male; Neuralgia; Paclitaxel; Presynaptic Term

2016
Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists.
    Pain, 1998, Volume: 77, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Blood Press

1998
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
    Brain structure & function, 2018, Volume: 223, Issue:6

    Topics: Action Potentials; Animals; Animals, Newborn; Channelrhodopsins; Disease Models, Animal; Excitatory

2018
Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jun-27, Volume: 32, Issue:26

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Antibodies; Disease Models, Ani

2012