2-amino-5-phosphonovalerate has been researched along with Nerve Pain in 5 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 7.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| "The present study investigated the role of the amygdala N-methyl-d-aspartate (NMDA) receptors/nitric oxide synthase pathway in morphine-induced anti-allodynia." | 3.91 | Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway. ( Delphi, L; Rezayof, A; Tolou-Dabbaghian, B, 2019) |
| "In paclitaxel-treated rats, the baseline frequency of miniature EPSCs (mEPSCs) was significantly increased; the NMDAR antagonist 2-amino-5-phosphonopentanoic acid (AP5) completely normalized this frequency." | 1.43 | Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain. ( Chen, H; Chen, SR; Pan, HL; Xie, JD; Zeng, WA, 2016) |
| "Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood." | 1.38 | Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. ( Barres, B; Boroujerdi, A; Corpe, M; Deng, P; Eroglu, C; Kim, DS; Lee, J; Li, KW; Luo, ZD; Park, J; Peter Yu, Y; Sharp, K; Steward, O; Xu, ZC; Zaucke, F; Zhang, X; Zhou, CY, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tolou-Dabbaghian, B | 1 |
| Delphi, L | 1 |
| Rezayof, A | 1 |
| Xie, JD | 1 |
| Chen, SR | 1 |
| Chen, H | 1 |
| Zeng, WA | 1 |
| Pan, HL | 1 |
| Sorkin, LS | 1 |
| Puig, S | 1 |
| Jones, DL | 1 |
| Kelly, CJ | 1 |
| Martina, M | 1 |
| Kim, DS | 1 |
| Li, KW | 1 |
| Boroujerdi, A | 1 |
| Peter Yu, Y | 1 |
| Zhou, CY | 1 |
| Deng, P | 1 |
| Park, J | 1 |
| Zhang, X | 1 |
| Lee, J | 1 |
| Corpe, M | 1 |
| Sharp, K | 1 |
| Steward, O | 1 |
| Eroglu, C | 1 |
| Barres, B | 1 |
| Zaucke, F | 1 |
| Xu, ZC | 1 |
| Luo, ZD | 1 |
5 other studies available for 2-amino-5-phosphonovalerate and Nerve Pain
| Article | Year |
|---|---|
Blockade of NMDA Receptors and Nitric Oxide Synthesis Potentiated Morphine-Induced Anti-Allodynia via Attenuating Pain-Related Amygdala pCREB/CREB Signaling Pathway.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Cyclic AMP Response Element-Binding Protein; Enzyme | 2019 |
Presynaptic N-Methyl-d-aspartate (NMDA) Receptor Activity Is Increased Through Protein Kinase C in Paclitaxel-induced Neuropathic Pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Ganglia, Spinal; Male; Neuralgia; Paclitaxel; Presynaptic Term | 2016 |
Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Blood Press | 1998 |
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
Topics: Action Potentials; Animals; Animals, Newborn; Channelrhodopsins; Disease Models, Animal; Excitatory | 2018 |
Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Antibodies; Disease Models, Ani | 2012 |