2-amino-5-phosphonovalerate has been researched along with Nerve Degeneration in 27 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Memantine, an N-methyl-D-aspartate (NMDA) receptor antagonist, reduces the clinical deterioration in moderate-to-severe Alzheimer disease (AD) for which other treatments are not available." | 3.72 | Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. ( Grundke-Iqbal, I; Haque, N; Iqbal, K; Li, L; Sengupta, A, 2004) |
| "By contrast, cells from scrapie-infected mice fired calcium spikes repetitively and the long, slow AHP, which in control cells inhibited repetitive firing, was absent." | 1.30 | Alterations in potassium currents may trigger neurodegeneration in murine scrapie. ( Fraser, JR; Jeffrey, M; Johnston, AR; MacLeod, N, 1998) |
| "CGP 37849 was a weaker neuroprotectant than MK-801 (ED50 0." | 1.29 | A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy. ( Fagg, GE; Massieu, L; McVey, M; Thedinga, KH, 1993) |
| "Seizures were observed 50 min after injecting Dtx (35 pmol) into the amygdala, though significant neuronal loss was not evident." | 1.28 | Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker. ( Bagetta, G; Dolly, JO; Nisticó, G, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 19 (70.37) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Durakoglugil, MS | 1 |
| Wasser, CR | 1 |
| Wong, CH | 1 |
| Pohlkamp, T | 1 |
| Xian, X | 1 |
| Lane-Donovan, C | 1 |
| Fritschle, K | 1 |
| Naestle, L | 1 |
| Herz, J | 1 |
| Berry, JN | 2 |
| Sharrett-Field, LJ | 2 |
| Butler, TR | 2 |
| Prendergast, MA | 2 |
| Li, L | 1 |
| Sengupta, A | 1 |
| Haque, N | 1 |
| Grundke-Iqbal, I | 1 |
| Iqbal, K | 1 |
| Wu, SZ | 1 |
| Jiang, S | 1 |
| Sims, TJ | 1 |
| Barger, SW | 1 |
| Whetsell, WO | 1 |
| Schwarcz, R | 2 |
| Massieu, L | 2 |
| Thedinga, KH | 2 |
| McVey, M | 1 |
| Fagg, GE | 2 |
| Virgili, M | 1 |
| Facchinetti, F | 1 |
| Ciani, E | 1 |
| Contestabile, A | 1 |
| Pozzo Miller, LD | 1 |
| Mahanty, NK | 1 |
| Connor, JA | 1 |
| Landis, DM | 1 |
| Gould, E | 1 |
| Cameron, HA | 1 |
| McEwen, BS | 1 |
| Couratier, P | 1 |
| Hugon, J | 1 |
| Sindou, P | 1 |
| Vallat, JM | 1 |
| Dumas, M | 1 |
| McMaster, OG | 1 |
| Baran, H | 1 |
| Wu, HQ | 1 |
| Du, F | 1 |
| French, ED | 1 |
| Kadari, A | 1 |
| Windisch, JM | 1 |
| Ebendal, T | 1 |
| Schneider, R | 1 |
| Humpel, C | 1 |
| Vanický, I | 1 |
| Marsala, M | 1 |
| Yaksh, TL | 1 |
| Almeida, A | 1 |
| Heales, SJ | 1 |
| Bolaños, JP | 1 |
| Medina, JM | 1 |
| Johnston, AR | 1 |
| Fraser, JR | 1 |
| Jeffrey, M | 1 |
| MacLeod, N | 1 |
| Mennini, T | 1 |
| Cagnotto, A | 1 |
| Carvelli, L | 1 |
| Comoletti, D | 1 |
| Manzoni, C | 1 |
| Muzio, V | 1 |
| Rizzi, M | 1 |
| Vezzani, A | 2 |
| Ravizza, T | 1 |
| Moneta, D | 1 |
| Bottazzi, B | 1 |
| Peri, G | 1 |
| Garlanda, C | 1 |
| Hirsch, E | 1 |
| Richards, GJ | 1 |
| Mantovani, A | 1 |
| Sauer, D | 2 |
| Allegrini, PR | 2 |
| Amacker, H | 1 |
| Bagetta, G | 3 |
| Nisticó, G | 3 |
| Dolly, JO | 1 |
| Mariangela, S | 1 |
| Cristina, GA | 1 |
| Cristina, FM | 1 |
| Costantino, M | 1 |
| Giovanni, B | 1 |
| Bowery, NG | 1 |
| Britton, P | 1 |
| Whitton, P | 1 |
| Miyamoto, T | 1 |
| Sakurai, T | 1 |
| Okada, Y | 1 |
| McNamara, D | 1 |
| Dingledine, R | 1 |
| Chen, Y | 1 |
| Wang, Y | 1 |
| Modrusan, Z | 1 |
| Sheng, M | 1 |
| Kaminker, JS | 1 |
| Self, RL | 1 |
| Smith, KJ | 1 |
| Littleton, JM | 1 |
| Pauly, JR | 1 |
| Mulholland, PJ | 1 |
27 other studies available for 2-amino-5-phosphonovalerate and Nerve Degeneration
| Article | Year |
|---|---|
Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; Calcium; Cells, Cultured; Cerebral Co | 2021 |
Temporal dependence of cysteine protease activation following excitotoxic hippocampal injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calpain; Cell Death; Cell Survival; Cells, Cultured; Cysteine | 2012 |
Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Alzheimer Disease; Animals; Calcium-Calmodulin-Dependent Protein Kinase | 2004 |
Schwann cells exhibit excitotoxicity consistent with release of NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Calcium; Cell Death; Cells, Cultured; Cu | 2005 |
The organotypic tissue culture model of corticostriatal system used for examining amino acid neurotoxicity and its antagonism: studies on kainic acid, quinolinic acid and (-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Animals; Caudate Nucleus; Corpus Striat | 1983 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | 1993 |
Decreased excitotoxic sensitivity in the olfactory cortex of adult rats after neonatal NMDA blockade.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Animals, Newborn; Enzyme Induction; Hipp | 1994 |
Spontaneous pyramidal cell death in organotypic slice cultures from rat hippocampus is prevented by glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Culture Techniques; Excitatory Amino Acid Antagoni | 1994 |
Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Brain; Dizocilpine Maleate; Female; Glial Fib | 1994 |
Cell culture evidence for neuronal degeneration in amyotrophic lateral sclerosis being linked to glutamate AMPA/kainate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aged; Amino Acids; Amyotrophic La | 1993 |
gamma-Acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminobutyrate Transaminase; Alkynes; Amino Acids; Aminocaproates; Ani | 1993 |
Cell death of adult pyramidal CA1 neurons after intraventricular injection of a novel peptide derived from trkA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Sequence; Analysis of | 1997 |
Neurodegeneration induced by reversed microdialysis of NMDA; a quantitative model for excitotoxicity in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Corpus Striatum; Drug Combinations; Excitatory Amino Acid Agon | 1998 |
Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antimycin A; Cell Respiration; Cells, Cultured; Cerebral Corte | 1998 |
Alterations in potassium currents may trigger neurodegeneration in murine scrapie.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Calcium; Electrophysiology; Excitatory Amin | 1998 |
Biochemical and pharmacological evidence of a functional role of AMPA receptors in motor neuron dysfunction in mnd mice.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amyotrophic L | 1999 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; | 2001 |
Evaluation of quinolinic acid induced excitotoxic neurodegeneration in rat striatum by quantitative magnetic resonance imaging in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Edema; Choline O-Acetyltransferase; Corpus Striat | 1992 |
Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Diseases; Dizocilpine Maleate; Elapid Venoms; Electroenc | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinica | 1992 |
Glutamate transmission is involved in the mechanisms of neuronal degeneration produced by intrahippocampal tetanus toxin in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; gamma-Aminobutyric Acid; Hippocampus; Mal | 1992 |
The degeneration of the excitatory climbing fibers enhances [3H]MK-801 and [3H]CGP 39653 binding sites in the rat cerebellar cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebellar Cortex; Dizocilpine Maleate; Kinetics; Male; Nerve | 1992 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; | 1992 |
Masking effect of NMDA receptor antagonists on the formation of long-term potentiation (LTP) in superior colliculus slices from the guinea pig.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Denervation; Dibenzocycloheptenes; Dipeptides; | 1990 |
Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; gamma-Aminob | 1990 |
Regulation of neuronal gene expression and survival by basal NMDA receptor activity: a role for histone deacetylase 4.
Topics: Animals; Cell Survival; Cells, Cultured; Female; Gene Expression Regulation; Gene Knockdown Techniqu | 2014 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.
Topics: Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excit | 2010 |