2-amino-5-phosphonovalerate has been researched along with Muscle Contraction in 24 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 7.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "The role of N-methyl-D-aspartate (NMDA) receptors in the reflex pressor response to static muscle contraction and passive stretch was examined by microdialyzing the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate (AP-5) into the L7 or L6 and S1 levels of the dorsal horn of anesthetized cats." | 3.69 | NMDA receptor blockade in cat dorsal horn blunts reflex pressor response to muscle contraction and stretch. ( Ally, A; Hand, GA; Keister, AW; Meintjes, AF; Wilson, LB, 1996) |
| " In the present investigation, kynurenate (KYN), a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and 2-amino-5-phosphonovalerate (APV), a competitive NMDA receptor antagonist, were tested in the pattern, latency and duration of the spinal seizures." | 3.68 | Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords. ( Daló, NL; Piña, JC, 1990) |
| "Ketamine, which is a general anaesthetic that induces a dissociative anaesthesia, acts by blocking the N-methyl-D-aspartate receptor (NMDAr) in the brain." | 1.35 | The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle. ( Bae, YM; Cho, SI; Kim, B; Kim, JG; Kim, SH; Kim, YS; Noh, HJ; Park, SH; Woo, NS, 2009) |
| " The striatal application of NBQX reduced the severity and increased the latency to onset of dystonia significantly only at a dosage of 0." | 1.34 | Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant. ( Richter, A; Sander, SE, 2007) |
| " Since the GLU receptors present at NMJ have been reported to be predominantly N-methyl-D-aspartate (NMDA) subtype, some non-competitive and competitive NMDA receptor blockers, MK801, ketamine, dextromethorphan and CGP 37849, and GLU release inhibitors, clonidine, guanfacine, tizanidine were used at their optimum concentrations in medium after having found them from dose-response curves." | 1.30 | N-methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission. ( Günel, MA; Kara, I; Koyuncuoğlu, H; Nurten, A; Yamantürk, P, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 14 (58.33) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Noh, HJ | 1 |
| Bae, YM | 1 |
| Park, SH | 1 |
| Kim, JG | 1 |
| Kim, B | 1 |
| Kim, YS | 1 |
| Kim, SH | 1 |
| Cho, SI | 1 |
| Woo, NS | 1 |
| Petsanis, K | 1 |
| Chatzisotiriou, A | 1 |
| Kapoukranidou, D | 1 |
| Simeonidou, C | 1 |
| Kouvelas, D | 1 |
| Albani, M | 1 |
| Tsai, MC | 1 |
| Tang, CY | 1 |
| Chang, YT | 1 |
| Cheng, CL | 1 |
| Liao, JM | 1 |
| Lee, SD | 1 |
| Pan, SF | 1 |
| Chen, MJ | 1 |
| Huang, PC | 1 |
| Lin, TB | 1 |
| Cahusac, PM | 1 |
| Evans, RH | 1 |
| Hill, RG | 1 |
| Rodriquez, RE | 1 |
| Smith, DA | 1 |
| Maggi, CA | 2 |
| Lecci, A | 2 |
| Garret, C | 2 |
| Giuliani, S | 2 |
| Solomon, IC | 1 |
| Motekaitis, AM | 1 |
| Wong, MK | 1 |
| Kaufman, MP | 3 |
| Hill, JM | 2 |
| Pickar, JG | 1 |
| Hand, GA | 1 |
| Meintjes, AF | 1 |
| Keister, AW | 1 |
| Ally, A | 3 |
| Wilson, LB | 2 |
| Xie, Z | 1 |
| Yip, S | 1 |
| Morishita, W | 1 |
| Sastry, BR | 1 |
| Adreani, CM | 1 |
| Schacher, S | 1 |
| Wu, F | 1 |
| Sun, ZY | 1 |
| Svendsen, F | 1 |
| Tjølsen, A | 1 |
| Hole, K | 1 |
| Koyuncuoğlu, H | 1 |
| Kara, I | 1 |
| Günel, MA | 1 |
| Nurten, A | 1 |
| Yamantürk, P | 1 |
| Crews, AD | 1 |
| Asmundsson, G | 1 |
| Mokler, DJ | 1 |
| Rossetti, ZL | 1 |
| Mameli, M | 1 |
| Vargiu, R | 1 |
| Fadda, F | 1 |
| Mancinelli, R | 1 |
| Reidman, DA | 1 |
| Maher, TJ | 1 |
| Chaiyakul, P | 1 |
| Crespi, F | 1 |
| Campagnola, M | 1 |
| Neudeck, A | 1 |
| McMillan, K | 1 |
| Rossetti, Z | 1 |
| Pastorino, A | 1 |
| Garbin, U | 1 |
| Fratta-Pasini, A | 1 |
| Reggiani, A | 1 |
| Gaviraghi, G | 1 |
| Cominacini, L | 1 |
| Coşkun, U | 1 |
| Gülay, S | 1 |
| Frye, GD | 1 |
| Daló, NL | 1 |
| Piña, JC | 1 |
| Coan, EJ | 1 |
| Irving, AJ | 1 |
| Collingridge, GL | 1 |
| Sander, SE | 1 |
| Richter, A | 1 |
24 other studies available for 2-amino-5-phosphonovalerate and Muscle Contraction
| Article | Year |
|---|---|
The vasodilatory effect of ketamine is independent of the N-methyl-D-aspartate receptor: lack of functional N-methyl-D-aspartate receptors in rat mesenteric artery smooth muscle.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Dissociative; Animals; Excitatory Amino Acid Antagonists; | 2009 |
Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Axotomy; Behavior, Animal; Excitatory Amino | 2012 |
Effects of selective unilateral dorsal root(s) rhizotomy on micturition reflex in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Dose-Respons | 2006 |
The behavioural effects of an N-methylaspartate receptor antagonist following application to the lumbar spinal cord of conscious rats.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Glutamates; Glutamine; Hindlimb; Injections, S | 1984 |
Spinal effects of selective NK-1 and NK-2 receptor antagonists on bladder motility in anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Afferent Pathways; Animals; Capsaicin; Indoles; Isoind | 1993 |
NMDA receptors in caudal ventrolateral medulla mediate reflex airway dilation arising from the hindlimb.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Airway Resistance; Animals; Dogs; | 1994 |
Blockade of non-NMDA receptors attenuates reflex pressor response to static contraction.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biphenyl Compounds; Bloo | 1994 |
Evidence for a role of tachykinins as sensory transmitters in the activation of micturition reflex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Injections, Spinal; Male; Muscle Contraction; Neuro | 1993 |
NMDA receptor blockade in cat dorsal horn blunts reflex pressor response to muscle contraction and stretch.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Lumbos | 1996 |
Tetanus-induced potentiation of inhibitory postsynaptic potentials in hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Guinea Pigs; Hippocampus; Male; Membrane | 1995 |
Intrathecal blockade of both NMDA and non-NMDA receptors attenuates the exercise pressor reflex in cats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Cats; De | 1996 |
Pathway-specific synaptic plasticity: activity-dependent enhancement and suppression of long-term heterosynaptic facilitation at converging inputs on a single target.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Aplysia; Electric Stimulation; Ganglia, Inv | 1997 |
AMPA and NMDA receptor-dependent spinal LTP after nociceptive tetanic stimulation.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Femal | 1998 |
N-methyl-D-aspartate antagonists, glutamate release inhibitors, 4-aminopyridine at neuromuscular transmission.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; ATP-Binding | 1998 |
Segmental effect of NMDA block in the dorsal horn on the pressor reflex.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Blood Pressure; Cats; Excitatory Amino A | 1998 |
Effects of ventrolateral medullary NMDA-receptor antagonism on biogenic amines and pressor response to muscle contraction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biogenic Amines; Brain Chemistry; Dopamine; Excitatory Amino A | 1998 |
Biphasic effects of NMDA on the motility of the rat portal vein.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; E | 2000 |
Modulation of extracellular glutamate and pressor response to muscle contraction during NMDA-receptor blockade in the rostral ventrolateral medulla.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Excitatory Amino Acid Antagonists; Extracellul | 2000 |
Can voltammetry measure nitrogen monoxide (NO) and/or nitrites?
Topics: 2-Amino-5-phosphonovalerate; Animals; Aorta; Carbon; Carbon Fiber; Electrophysiology; Enzyme Inhibit | 2001 |
Glutamate mediated responses in isolated trachea preparations from control and ovalbumin sensitized guinea-pigs.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbachol; Dose-Response Relationship, Drug; Electric Stimulat | 2002 |
Interaction of ethanol and L-glutamate in the guinea pig ileum myenteric plexus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atropine; Electric Stimulation; Ethanol; Female; Glutamates; G | 1991 |
Kynurenate and 2-amino-5-phosphonovalerate alter the spinal seizures evoked by sudden cooling of toad isolated cords.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bufo marinus; Cold Temperature; Kynurenic Acid; Muscle Contrac | 1990 |
Low-frequency activation of the NMDA receptor system can prevent the induction of LTP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Down-Regulation; Electric Stimulation; Evoked Potentials; Fema | 1989 |
Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Cricetinae; Disease Models, Animal; Dizocilpine Maleate; Do | 2007 |