2-amino-5-phosphonovalerate has been researched along with Morphine Dependence in 7 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Morphine addiction is known as a serious social problem." | 1.51 | Electrical stimulation mPFC affects morphine addiction by changing glutamate concentration in the ventral tegmental area. ( Alaei, H; Eidi, A; Keramatian, A; Radahmadi, M, 2019) |
| "Verapamil was used to isolate NMDA-dependent LTP." | 1.32 | Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus. ( Fathollahi, Y; Kazemnejad, A; Salmanzadeh, F; Semnanian, S; Shafizadeh, M, 2003) |
| "Morphine was administered in a single dose (300 mg/kg) of a slow release preparation." | 1.30 | Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists. ( Cabello, P; Contreras, E; Germany, A; González, P; Norris, B, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salmanzadeh, F | 1 |
| Fathollahi, Y | 2 |
| Semnanian, S | 2 |
| Shafizadeh, M | 1 |
| Kazemnejad, A | 1 |
| Koyuncuoğlu, H | 1 |
| Hatipoğlu, I | 1 |
| Sarica, O | 1 |
| Hong, M | 1 |
| Milne, B | 1 |
| Jhamandas, K | 1 |
| González, P | 1 |
| Cabello, P | 1 |
| Germany, A | 1 |
| Norris, B | 1 |
| Contreras, E | 1 |
| Pourmotabbed, A | 1 |
| Motamedi, F | 1 |
| Mansouri, FA | 1 |
| Ivanov, A | 1 |
| Aston-Jones, G | 1 |
| Keramatian, A | 1 |
| Alaei, H | 1 |
| Eidi, A | 1 |
| Radahmadi, M | 1 |
7 other studies available for 2-amino-5-phosphonovalerate and Morphine Dependence
| Article | Year |
|---|---|
Dependence on morphine leads to a prominent sharing among the different mechanisms of long-term potentiation in the CA1 region of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Calcium Channel Blockers; Cognition; Electri | 2003 |
Morphine physical dependence intensification by hypoglycemia: NMDA receptor involvement.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Brain; Dizocilpine Maleate; Hypoglycemia; In | 1994 |
Evidence for the involvement of excitatory amino acid pathways in the development of precipitated withdrawal from acute and chronic morphine: an in vivo voltammetric study in the rat locus coeruleus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Ventricles; Dipeptides; Excitatory Amino | 1993 |
Decrease of tolerance to, and physical dependence on morphine by, glutamate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Tolerance; Excitatory Amino Acid Ant | 1997 |
Involvement of NMDA receptors and voltage-dependent calcium channels on augmentation of long-term potentiation in hippocampal CA1 area of morphine dependent rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channel Blockers; Calcium Channels; Electrophysiology; | 1998 |
Local opiate withdrawal in locus coeruleus neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; Bari | 2001 |
Electrical stimulation mPFC affects morphine addiction by changing glutamate concentration in the ventral tegmental area.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; Excitatory Amino Acid Antagonis | 2019 |