2-amino-5-phosphonovalerate has been researched along with Memory Disorders in 19 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pregnenolone sulfate (PREGS) is an excitatory neurosteroid that acts as a N-methyl-D-aspartate (NMDA) receptor agonist and GABAA receptor antagonist." | 5.42 | The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. ( Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L, 2015) |
| "Muscimol pretreatment did not change D-AP5-induced anxiolytic-like behaviors but potentiated avoidance memory impairment." | 1.43 | The role of CA3 GABAA receptors on anxiolytic-like behaviors and avoidance memory deficit induced by NMDA receptor antagonists. ( Farahizadeh, M; Nasehi, M; Zarrabian, S; Zarrindast, MR, 2016) |
| "Pregnenolone sulfate (PREGS) is an excitatory neurosteroid that acts as a N-methyl-D-aspartate (NMDA) receptor agonist and GABAA receptor antagonist." | 1.42 | The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. ( Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L, 2015) |
| "The early phase of Alzheimer's disease (AD) is characterized by hippocampus-dependent memory deficits and impaired synaptic plasticity." | 1.42 | Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease. ( Barik, J; Bethus, I; Chafai, M; Kootar, S; Lanté, F; Marie, H; Mouska, X; Pereira, AR; Raymond, EF, 2015) |
| "Cholestasis was induced in male Wistar rats through double-ligation of the main bile duct (at two points) and transection of the interposed segment." | 1.39 | Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats. ( Hosseini, N; Nasehi, M; Radahmadi, M; Zarrindast, MR, 2013) |
| " Inverted U-shaped dose-response curves were obtained for the ability of gamma-LGLA and D-AP5 to decrease retention, with maximum effects occurring at doses of 2-20 nmol/mouse for gamma-LGLA and 0." | 1.28 | Memory deficits induced by gamma-L-glutamyl-L-aspartate and D-2-amino-6-phosphonovalerate in a Y-maze avoidance task: relationship to NMDA receptor antagonism. ( de Barry, J; Mathis, C; Ungerer, A, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zarrabian, S | 2 |
| Nasehi, M | 5 |
| Farrahizadeh, M | 1 |
| Zarrindast, MR | 7 |
| Sengar, AS | 1 |
| Ellegood, J | 1 |
| Yiu, AP | 1 |
| Wang, H | 1 |
| Wang, W | 1 |
| Juneja, SC | 1 |
| Lerch, JP | 1 |
| Josselyn, SA | 1 |
| Henkelman, RM | 1 |
| Salter, MW | 1 |
| Egan, SE | 1 |
| Hosseini, N | 1 |
| Radahmadi, M | 1 |
| Shinohara, K | 1 |
| Hata, T | 1 |
| Rasekhi, K | 1 |
| Oryan, S | 1 |
| Dastgheib, M | 1 |
| Dehpour, AR | 1 |
| Heidari, M | 1 |
| Moezi, L | 1 |
| Farahizadeh, M | 1 |
| Parsaei, L | 1 |
| Torkaman-Boutorabi, A | 1 |
| Asadi, F | 1 |
| Hajikhani, M | 1 |
| Ebrahimi-Ghiri, M | 1 |
| Fellini, L | 1 |
| Florian, C | 1 |
| Courtey, J | 1 |
| Roullet, P | 1 |
| Traverso, LM | 1 |
| Quintero, E | 1 |
| Vargas, JP | 1 |
| De la Casa, LG | 1 |
| Lopez, JC | 1 |
| Ardjmand, A | 1 |
| Rezayof, A | 1 |
| Tadano, T | 1 |
| Hozumi, S | 1 |
| Yamadera, F | 1 |
| Murata, A | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Nakagawasai, O | 1 |
| Kisara, K | 1 |
| Melik, E | 1 |
| Babar, E | 1 |
| Ozen, E | 1 |
| Ozgunen, T | 1 |
| Gutnikov, SA | 1 |
| Rawlins, JN | 1 |
| Wei, H | 1 |
| Xiong, W | 1 |
| Yang, S | 1 |
| Zhou, Q | 1 |
| Liang, C | 1 |
| Zeng, BX | 1 |
| Xu, L | 1 |
| Mathis, C | 1 |
| de Barry, J | 1 |
| Ungerer, A | 1 |
| Lanté, F | 1 |
| Chafai, M | 1 |
| Raymond, EF | 1 |
| Pereira, AR | 1 |
| Mouska, X | 1 |
| Kootar, S | 1 |
| Barik, J | 1 |
| Bethus, I | 1 |
| Marie, H | 1 |
| Hayashi, ML | 1 |
| Choi, SY | 1 |
| Rao, BS | 1 |
| Jung, HY | 1 |
| Lee, HK | 1 |
| Zhang, D | 1 |
| Chattarji, S | 1 |
| Kirkwood, A | 1 |
| Tonegawa, S | 1 |
19 other studies available for 2-amino-5-phosphonovalerate and Memory Disorders
| Article | Year |
|---|---|
The role of CA3 GABA
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Avoidance Learning; Baclofen; CA3 Region, Hippocampal | 2017 |
Vertebrate intersectin1 is repurposed to facilitate cortical midline connectivity and higher order cognition.
Topics: 2-Amino-5-phosphonovalerate; Adaptor Proteins, Vesicular Transport; Analysis of Variance; Animals; B | 2013 |
Effects of CA1 glutamatergic systems upon memory impairments in cholestatic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; Cholestasis; Excitatory Amino Acid Ag | 2013 |
[Post-training N-methyl-D-aspartate receptor blockade facilitates retention of acquired spatial memory in rats].
Topics: 2-Amino-5-phosphonovalerate; Animals; Male; Maze Learning; Memory; Memory Disorders; Rats; Rats, Wis | 2014 |
Involvement of the nucleus accumbens shell glutamatergic system in ACPA-induced impairment of inhibitory avoidance memory consolidation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arachidonic Acids; Avoidance Learning; Cannabinoid Receptor Ag | 2014 |
The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; CA1 Region, Hip | 2015 |
The role of CA3 GABAA receptors on anxiolytic-like behaviors and avoidance memory deficit induced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Avoidance Learning; Bicuculline; CA3 Region, Hippocam | 2016 |
Interaction between dorsal hippocampal NMDA receptors and lithium on spatial learning consolidation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; Catheters, Indwelling; Dose-Response | 2016 |
Interaction between NMDA and CB2 function in the dorsal hippocampus on memory consolidation impairment: an isobologram analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Excitatory Amino Acid Antagonists; Hippoca | 2017 |
Pharmacological intervention of hippocampal CA3 NMDA receptors impairs acquisition and long-term memory retrieval of spatial pattern completion task.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Excitatory Amino Acid Antagonists; Femal | 2009 |
Taste memory trace disruption by AP5 administration in basolateral amygdala.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Association Learning; Avoidance Learning; Conditioni | 2010 |
Involvement of central amygdala NMDA receptor mechanism in morphine state-dependent memory retrieval.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Amygdala; Animals; Avoidance Learning; Dose-Response Relations | 2011 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizoc | 2004 |
Hypofunction of the dorsal hippocampal NMDA receptors impairs retrieval of memory to partially presented foreground context in a single-trial fear conditioning in rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classica | 2006 |
Systemic NMDA antagonist CGP-37849 produces non-specific impairment in a working memory task: the effect does not resemble those of AP5 and of lesions of the hippocampus or fornix.
Topics: 2-Amino-5-phosphonovalerate; Animals; Hippocampus; Long-Term Potentiation; Male; Memory Disorders; M | 1996 |
Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; El | 2002 |
Memory deficits induced by gamma-L-glutamyl-L-aspartate and D-2-amino-6-phosphonovalerate in a Y-maze avoidance task: relationship to NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Dipep | 1991 |
Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Dexamethasone; Disease Models, Animal; E | 2015 |
Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Animals, Ne | 2004 |