2-amino-5-phosphonovalerate has been researched along with Magnesium Deficiency in 12 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Magnesium Deficiency: A nutritional condition produced by a deficiency of magnesium in the diet, characterized by anorexia, nausea, vomiting, lethargy, and weakness. Symptoms are paresthesias, muscle cramps, irritability, decreased attention span, and mental confusion, possibly requiring months to appear. Deficiency of body magnesium can exist even when serum values are normal. In addition, magnesium deficiency may be organ-selective, since certain tissues become deficient before others. (Harrison's Principles of Internal Medicine, 12th ed, p1936)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| "The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex." | 1.29 | In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. ( Abe, S; Akazawa, K; Chishaki, A; Goto, Y; Kato, M; Nakamura, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulyás-Kovács, A | 1 |
| Dóczi, J | 1 |
| Tarnawa, I | 1 |
| Détári, L | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Világi, I | 1 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 2 |
| Zhang, L | 1 |
| Carlen, PL | 2 |
| Burnham, WM | 1 |
| Nakamura, M | 1 |
| Abe, S | 1 |
| Goto, Y | 1 |
| Chishaki, A | 1 |
| Akazawa, K | 1 |
| Kato, M | 1 |
| Hsu, KS | 1 |
| Ho, WC | 1 |
| Huang, CC | 1 |
| Tsai, JJ | 1 |
| Takuma, S | 1 |
| Mizuno, T | 1 |
| Kanazawa, I | 1 |
| Sakurai, M | 1 |
| Dreier, JP | 1 |
| Heinemann, U | 1 |
| Gean, PW | 1 |
| Nakanishi, H | 1 |
| Kamata, O | 1 |
| Katsuda, N | 1 |
| Aram, JA | 1 |
| Lodge, D | 1 |
| Tancredi, V | 1 |
| Avoli, M | 1 |
| Hwa, GG | 1 |
12 other studies available for 2-amino-5-phosphonovalerate and Magnesium Deficiency
| Article | Year |
|---|---|
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicucul | 2002 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Body Weight; Dizocilpine Maleate | 1994 |
Transient removal of extracellular Mg(2+) elicits persistent suppression of LTP at hippocampal CA1 synapses via PKC activation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Ca | 2000 |
Effect of neonatal capsaicin treatment on neural activity in the medullary dorsal horn of neonatal rats evoked by electrical stimulation to the trigeminal afferents: an optical, electrophysiological, and quantitative study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathw | 2001 |
Differential induction of LTP and LTD is not determined solely by instantaneous calcium concentration: an essential involvement of a temporal factor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Signali | 2001 |
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In | 1990 |
NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Culture Media; | 1990 |
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr | 1989 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro | 1987 |
Low-magnesium epilepsy in rat hippocampal slices: inhibitory postsynaptic potentials in the CA1 subfield.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebrospinal Fluid; Electric Stimulation; Electrophysiology; | 1988 |