2-amino-5-phosphonovalerate has been researched along with Ischemic Attack, Transient in 24 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 7.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| " Seizures were evoked with bicuculline (3." | 7.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| " Seizures were evoked with pilocarpine (400 mg/kg, i." | 3.70 | The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M; Stelmasiak, Z, 2000) |
| " Seizures were evoked with bicuculline (3." | 3.70 | The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000) |
| " The noncompetitive antagonist MK-801 and a glycine-site blocker were equally neuroprotective in both normal and reduced conditions, but there was a significant rightward shift in the dose-response curves of the competitive antagonists APV and CPP and the uncompetitive antagonist memantine." | 1.31 | Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro. ( Eshak, M; Iannotti, F; Pringle, AK; Self, J, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.67) | 18.7374 |
| 1990's | 14 (58.33) | 18.2507 |
| 2000's | 5 (20.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Lei, Z | 1 |
| Xu, ZC | 1 |
| Ye, H | 1 |
| Jalini, S | 1 |
| Zhang, L | 1 |
| Charlton, M | 1 |
| Carlen, PL | 1 |
| Maier, CM | 1 |
| Sun, GH | 1 |
| Kunis, DM | 1 |
| Giffard, RG | 1 |
| Steinberg, GK | 1 |
| Sauer, D | 2 |
| Weber, E | 1 |
| Lüönd, G | 1 |
| Da Silva, F | 1 |
| Allegrini, PR | 2 |
| Stanimirovic, DB | 1 |
| Micic, DV | 2 |
| Markovic, M | 1 |
| Spatz, M | 2 |
| Mrsulja, BB | 2 |
| Ghribi, O | 1 |
| Callebert, J | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Hori, N | 1 |
| Carpenter, DO | 1 |
| Okada, M | 1 |
| Ueda, H | 1 |
| Kometani, M | 1 |
| Nakao, K | 1 |
| Kohjimoto, Y | 1 |
| Takahashi, I | 1 |
| Tanaka, I | 1 |
| Onitsuka, M | 1 |
| Mihara, S | 1 |
| Yamamoto, S | 1 |
| Shigemori, M | 1 |
| Higashi, H | 1 |
| Martin, RL | 1 |
| Hakuba, N | 1 |
| Koga, K | 1 |
| Shudou, M | 1 |
| Watanabe, F | 1 |
| Mitani, A | 1 |
| Gyo, K | 1 |
| Rejdak, K | 2 |
| Rejdak, R | 2 |
| Stelmasiak, Z | 1 |
| Czuczwar, SJ | 2 |
| Kleinrok, Z | 2 |
| Sieklucka-Dziuba, M | 2 |
| Pringle, AK | 1 |
| Self, J | 1 |
| Eshak, M | 1 |
| Iannotti, F | 1 |
| Lauritzen, M | 1 |
| Hansen, AJ | 2 |
| Nellgård, B | 1 |
| Wieloch, T | 1 |
| Salińska, E | 2 |
| Pluta, R | 2 |
| Puka, M | 1 |
| Lazarewicz, JW | 2 |
| Lobner, D | 1 |
| Lipton, P | 1 |
| Stanimirović, D | 1 |
| Roman, R | 1 |
| Bartkowski, H | 1 |
| Simon, R | 1 |
| Swan, JH | 1 |
| Evans, MC | 1 |
| Meldrum, BS | 1 |
| Benveniste, H | 1 |
| Jørgensen, MB | 1 |
| Diemer, NH | 1 |
24 other studies available for 2-amino-5-phosphonovalerate and Ischemic Attack, Transient
| Article | Year |
|---|---|
Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Biophysics; | 2009 |
Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2010 |
Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Evoked Potential | 1995 |
The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Constriction; Glial Fibrillary Acidi | 1995 |
'Therapeutic window's for multiple drug treatment of experimental cerebral ischemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Animals; Drug Therapy, Combination; Gerbillinae; Ischemic Attack, Trans | 1994 |
Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Extracellular Spa | 1994 |
Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium Channels; Cell Death; Electrophysiology; Glycine; Isch | 1994 |
Neuroprotective effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid in the gerbil model of transient global cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Excitatory Amino Acid Antagonists; Gerbillinae; | 1997 |
Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Cell Membrane; Cobalt; Glucose; Hemoglobins; Hippoc | 1998 |
Block of rapid depolarization induced by in vitro energy depletion of rat dorsal vagal motoneurones.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bepridil; Brain Stem; Ca | 1999 |
Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Animals; Audiometry, Evoked Response; Cerebrovascular Circulation; Coch | 2000 |
The effect of CGP-40116 on pilocarpine evoked seizures in mice exposed to transient episode of brain ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Brain; Brain Chemistry; Car | 2000 |
Reducing conditions significantly attenuate the neuroprotective efficacy of competitive, but not other NMDA receptor antagonists in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dithionitrobenzoic Acid; Dithiothreitol; Dizocilpine Maleate; | 2000 |
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; D | 2000 |
The effect of glutamate receptor blockade on anoxic depolarization and cortical spreading depression.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cerebral Cortex; Cortical Spreading Depression; D | 1992 |
Postischemic blockade of AMPA but not NMDA receptors mitigates neuronal damage in the rat brain following transient severe cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Glucose; Blood Pressure; Body Temperature; Cell Death; D | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinica | 1992 |
Blockade of N-methyl-D-aspartate-sensitive excitatory amino acid receptors with 2-amino-5-phosphonovalerate reduces ischemia-evoked calcium redistribution in rabbit hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood-Brain Barrier; Calcium; Cerebral Cortex; Electroencephal | 1991 |
Sigma-ligands and non-competitive NMDA antagonists inhibit glutamate release during cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cyclazocine; Dizocilpine Maleate | 1990 |
Excitatory amino acid receptors, oxido-reductive processes and brain oedema following transient ischaemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anions; Brain Edema; Female; Gerbillinae; Ischemi | 1990 |
The specific NMDA receptor antagonist AP-7 attenuates focal ischemic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Ischemic Attack, Transient; Kineti | 1989 |
Participation of NMDA-receptors in ischemic changes of calcium homeostasis in rabbit brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Calcium; Female; Hippocampus; Homeostasis; Is | 1989 |
Long-term development of selective neuronal loss and the mechanism of protection by 2-amino-7-phosphonoheptanoate in a rat model of incomplete forebrain ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cell Survival; Ce | 1988 |
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Extracellular Space; Hippocampus; Ischemic Attack, Tr | 1988 |