2-amino-5-phosphonovalerate has been researched along with Innate Inflammatory Response in 16 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent electrophysiological studies by our group have suggested that increased excitation of spinal GABAergic neurons by activation of N-methyl-D-aspartate (NMDA) and non-NMDA receptors following intradermal injection of capsaicin results in the generation of DRRs that contribute to neurogenic inflammation." | 3.71 | NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats. ( Lin, Q; Willis, WD; Zou, X, 2001) |
| "Since hyperalgesia is a behavioral consequence of central sensitization, it should be attenuated at the level of the dorsal horn with NMDA receptor antagonists." | 1.32 | Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats. ( Hama, A; Sagen, J; Woon Lee, J, 2003) |
| "Muscle inflammation was induced by injection of turpentine oil into the gastrocnemius muscle, whereas superficial tissue inflammation was induced by an intraplantar injection of turpentine oil into the hindpaw." | 1.31 | Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat. ( Hu, JY; Zhao, ZQ, 2001) |
| " The NMDA receptor antagonist D-AP5 reversed this effect, leaving the (1S,3R)-ACPD dose-response curve unchanged in naive animals." | 1.30 | mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia. ( Berthele, A; Boxall, SJ; Tölle, TR; Urban, L; Zieglgänsberger, W, 1998) |
| "Ankle inflammation was induced in rats by subcutaneous injection of complete Freund's adjuvant and the firing properties of spinal neurons receiving afferent input from the inflamed areas were studied four to six days later." | 1.29 | The burst-like firing of spinal neurons in rats with peripheral inflammation is reduced by an antagonist of N-methyl-D-aspartate. ( Duggan, AW; Grubb, BD; Hope, PJ; Pubols, L; Riley, RC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mordel, J | 1 |
| Sheikh, A | 1 |
| Tsohataridis, S | 1 |
| Kanold, PO | 1 |
| Zehendner, CM | 1 |
| Luhmann, HJ | 1 |
| Yang, X | 1 |
| Yang, HB | 1 |
| Xie, QJ | 1 |
| Liu, XH | 1 |
| Hu, XD | 1 |
| Ren, K | 2 |
| Dubner, R | 2 |
| Grubb, BD | 1 |
| Riley, RC | 1 |
| Hope, PJ | 1 |
| Pubols, L | 1 |
| Duggan, AW | 1 |
| Chao, CC | 1 |
| Hu, S | 1 |
| Ehrlich, L | 1 |
| Peterson, PK | 1 |
| Kolhekar, R | 1 |
| Murphy, S | 1 |
| Gebhart, GF | 1 |
| Boxall, SJ | 1 |
| Berthele, A | 1 |
| Tölle, TR | 1 |
| Zieglgänsberger, W | 1 |
| Urban, L | 1 |
| Rygh, LJ | 1 |
| Svendsen, F | 1 |
| Hole, K | 1 |
| Tjølsen, A | 1 |
| Zou, X | 1 |
| Lin, Q | 1 |
| Willis, WD | 1 |
| Khakpay, R | 1 |
| Semnanian, S | 1 |
| Javan, M | 1 |
| Janahmadi, M | 1 |
| Hama, A | 1 |
| Woon Lee, J | 1 |
| Sagen, J | 1 |
| Müller, F | 1 |
| Heinke, B | 1 |
| Sandkühler, J | 1 |
| Lam, DK | 1 |
| Sessle, BJ | 1 |
| Cairns, BE | 1 |
| Hu, JW | 1 |
| Bhave, G | 1 |
| Karim, F | 1 |
| Carlton, SM | 1 |
| Gereau , RW | 1 |
| Hu, JY | 1 |
| Zhao, ZQ | 1 |
| Williams, GM | 1 |
| Hylden, JL | 1 |
| Ruda, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Mutations of the Glycine Gene Associated With Hyperekplexia on Central Pain Processing[NCT01476514] | 9 participants (Actual) | Interventional | 2011-10-31 | Terminated (stopped due to Recruitment problems) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
16 other studies available for 2-amino-5-phosphonovalerate and Innate Inflammatory Response
| Article | Year |
|---|---|
Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2016 |
Peripheral inflammation increased the synaptic expression of NMDA receptors in spinal dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory A | 2009 |
NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Freund's Adjuvant; Inflammation; Injectio | 1993 |
The burst-like firing of spinal neurons in rats with peripheral inflammation is reduced by an antagonist of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Female; | 1996 |
Interleukin-1 and tumor necrosis factor-alpha synergistically mediate neurotoxicity: involvement of nitric oxide and of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Astrocytes; Biological Transport; Biomarkers; Cell Death; Cells, Cultur | 1995 |
Thalamic NMDA receptors modulate inflammation-produced hyperalgesia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carrageenan; Excitatory Amino Acid Agonists; Hot Temperature; | 1997 |
mGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino | 1998 |
Increased spinal N-methyl-D-aspartate receptor function after 20 h of carrageenan-induced inflammation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carrageenan; Electrophysiology; Excitatory Amino Acid Antagoni | 2001 |
NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blotting, Western; Capsa | 2001 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estro | 2010 |
Differential efficacy of intrathecal NMDA receptor antagonists on inflammatory mechanical and thermal hyperalgesia in rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino A | 2003 |
Reduction of glycine receptor-mediated miniature inhibitory postsynaptic currents in rat spinal lamina I neurons after peripheral inflammation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthetics, Local; Animals; Animals, Newborn; Bicuculline; Dr | 2003 |
Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Electromyogra | 2005 |
Peripheral group I metabotropic glutamate receptors modulate nociception in mice.
Topics: Animals; Chromones; Excitatory Amino Acid Antagonists; Glycine; Hindlimb; Hot Temperature; Immunohis | 2001 |
Differential contributions of NMDA and non-NMDA receptors to spinal Fos expression evoked by superficial tissue and muscle inflammation in the rat.
Topics: Afferent Pathways; Animals; Cell Count; Dose-Response Relationship, Drug; Excitatory Amino Acid Anta | 2001 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; C | 1992 |