2-amino-5-phosphonovalerate has been researched along with Idiopathic Parkinson Disease in 6 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hallworth, NE | 1 |
| Bevan, MD | 1 |
| Shen, KZ | 1 |
| Johnson, SW | 1 |
| Carroll, CB | 1 |
| Holloway, V | 1 |
| Brotchie, JM | 1 |
| Mitchell, IJ | 1 |
| Olney, JW | 1 |
| Zorumski, CF | 1 |
| Stewart, GR | 1 |
| Price, MT | 1 |
| Wang, GJ | 1 |
| Labruyere, J | 1 |
| Turski, L | 1 |
| Klockgether, T | 1 |
| Turski, WA | 1 |
| Schwarz, M | 1 |
| Sontag, KH | 1 |
| Steiner, JP | 1 |
| Payne, KB | 1 |
| Main, CD | 1 |
| D'Alfonso, S | 1 |
| Jacobsen, KX | 1 |
| Hicks, TP | 1 |
| Staines, WA | 1 |
| Poulter, MO | 1 |
6 other studies available for 2-amino-5-phosphonovalerate and Idiopathic Parkinson Disease
| Article | Year |
|---|---|
Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Evoked Potentials; Excitatory Amino Acid An | 2005 |
Subthalamic stimulation evokes complex EPSCs in the rat substantia nigra pars reticulata in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Electric Stimulation; Excitatory Amino Acid | 2006 |
Neurochemical and behavioural investigations of the NMDA receptor-associated glycine site in the rat striatum: functional implications for treatment of parkinsonian symptoms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Binding, Competitive; Corpus Striatum; Dose- | 1995 |
Excitotoxicity of L-dopa and 6-OH-dopa: implications for Parkinson's and Huntington's diseases.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chick Embryo; Dibenzocyc | 1990 |
Blockade of excitatory neurotransmission in the globus pallidus induces rigidity and akinesia in the rat: implications for excitatory neurotransmission in pathogenesis of Parkinson's diseases.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Corpus Striatum; Dose-Response Relationship, Drug | 1990 |
GPI-1046 increases presenilin-1 expression and restores NMDA channel activity.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonis | 2010 |