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2-amino-5-phosphonovalerate and Hypoxia

2-amino-5-phosphonovalerate has been researched along with Hypoxia in 36 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."7.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)
"To investigate the effects of 2-amino-5-phosphonovalerate-pharmacology (AP-V) and bicuculline on somatostatin (SST)-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia."7.71Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia. ( Fan, XT; Ruan, HZ; Wu, XG; Xu, HW; Zhang, JH, 2001)
"The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation."7.68The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992)
" We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)."3.78Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012)
" Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis."3.77Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011)
"To investigate the effects of 2-amino-5-phosphonovalerate-pharmacology (AP-V) and bicuculline on somatostatin (SST)-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia."3.71Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia. ( Fan, XT; Ruan, HZ; Wu, XG; Xu, HW; Zhang, JH, 2001)
"The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation."3.68The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992)
"In the excised patch configuration anoxia had no effect on K(Ca) channel open probability (P(open)); however, in cell-attached mode, there was a reversible fivefold reduction in P(open) (from 0."1.39Oxygen-sensitive reduction in Ca²⁺-activated K⁺ channel open probability in turtle cerebrocortex. ( Buck, LT; Hogg, DW; Rodgers-Garlick, CI, 2013)
"Chemical anoxia induced by cyanide, rotenone or p-trifluoromethoxy-phenylhydrazone (FCCP) decreased pH(i) by >0."1.32Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances. ( Ballanyi, K; Raupach, T, 2004)
"Severe anoxia induces destabilisation of intracellular calcium homeostasis in neurones."1.31Responses to reversible anoxia of intracellular free and bound Ca(2+) in rat cortical slices. ( Lazarewicz, JW; Samoilov, MO; Semenov, DG; Zielonka, P, 2000)
"Brief anoxia (3 min) abolished EPSPs but reduced IPSPs by 64."1.29Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices. ( Krnjević, K; Zhu, PJ, 1994)
"After 10 min of anoxia the dentate granule cells recovered to 16 +/- 7% (mean +/- SE) of their preanoxic level when untreated and to 54 +/- 15% when treated with aminophosphonovaleric acid (APV)."1.28The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. ( Chambers, G; Cottrell, JE; Kass, IS, 1989)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19903 (8.33)18.7374
1990's12 (33.33)18.2507
2000's12 (33.33)29.6817
2010's9 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fernandes, GG1
Frias, AT1
Spiacci, A1
Pinheiro, LC1
Tanus-Santos, JE1
Zangrossi, H1
Almado, CE1
Leão, RM1
Machado, BH1
Mordel, J1
Sheikh, A1
Tsohataridis, S1
Kanold, PO1
Zehendner, CM1
Luhmann, HJ1
Hong, LZ1
Chai, CY1
Mutolo, D1
Bongianni, F1
Nardone, F1
Pantaleo, T1
Pokorski, M1
Kolesnikova, E1
Marczak, M1
Budzińska, K1
Maier, CM1
Sun, GH1
Kunis, DM1
Giffard, RG1
Steinberg, GK1
Marret, S1
Mukendi, R1
Gadisseux, JF1
Gressens, P1
Evrard, P1
Brooks, KJ1
Kauppinen, RA1
Zhu, PJ1
Krnjević, K1
Di Loreto, S1
Balestrino, M1
Onitsuka, M1
Mihara, S1
Yamamoto, S1
Shigemori, M1
Higashi, H1
Yamaguchi, S1
Endo, K1
Kitajima, T1
Ogata, H1
Hori, Y1
Diabira, D1
Hennou, S1
Chevassus-Au-Louis, N1
Ben-Ari, Y1
Gozlan, H1
Semenov, DG1
Samoilov, MO1
Zielonka, P1
Lazarewicz, JW1
Fan, XT1
Ruan, HZ1
Xu, HW1
Zhang, JH1
Wu, XG1
Radek, RJ1
Giardina, WJ1
Gieroba, ZJ1
Fullerton, MJ1
Funder, JW1
Blessing, WW1
Schurr, A1
West, CA1
Rigor, BM1
Tombaugh, GC1
Sapolsky, RM1
Kass, IS1
Chambers, G1
Cottrell, JE1
Nakanishi, H1
Kamata, O1
Katsuda, N1
Rothman, SM1
Wall, AM1
Mukandala, G1
Greig, NH1
O'Connor, JJ1
Jarosch, MS1
Gebhardt, C1
Fano, S1
Huchzermeyer, C1
Ul Haq, R1
Behrens, CJ1
Heinemann, U1
McGuire, M1
Liu, C1
Cao, Y1
Ling, L1
Kamendi, HW2
Cheng, Q2
Dergacheva, O2
Gorini, C2
Jameson, HS2
Wang, X2
McIntosh, JM1
Mendelowitz, D3
Duan, B1
Wang, YZ1
Yang, T1
Chu, XP1
Yu, Y1
Huang, Y1
Cao, H1
Hansen, J1
Simon, RP1
Zhu, MX1
Xiong, ZG1
Xu, TL1
Li, L1
Yang, R1
Sun, K1
Bai, Y1
Zhang, Z1
Zhou, L1
Qi, Z1
Qi, J1
Chen, L1
Dong, Y1
Zhang, W1
Lai, B1
Luan, WJ1
Zhu, YH1
Zhao, BQ1
Zheng, P1
Rodgers-Garlick, CI1
Hogg, DW1
Buck, LT1
Raupach, T1
Ballanyi, K1
Lyubimov, YE1
Emel'yanov, NA1
Izvarina, NL1
Hepp, S1
Gerich, FJ1
Müller, M1
Evans, C1
Wang, J1
Neff, R1
Frank, JG1
Pinol, RA1

Other Studies

36 other studies available for 2-amino-5-phosphonovalerate and Hypoxia

ArticleYear
Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia.
    Progress in neuro-psychopharmacology & biological psychiatry, 2019, 06-08, Volume: 92

    Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Arginine; Escape Reaction; Hypothalamus; Hypoxia; Ma

2019
Intrinsic properties of rostral ventrolateral medulla presympathetic and bulbospinal respiratory neurons of juvenile rats are not affected by chronic intermittent hypoxia.
    Experimental physiology, 2014, Volume: 99, Issue:7

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cervical Cord; Hypoxia; Male;

2014
Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.
    Neurobiology of disease, 2016, Volume: 88

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A

2016
Involvement of N-methyl-D-aspartate receptors in post-hypoxic depression of the dorsomedial medulla in cats.
    Neuroscience letters, 2003, Jun-12, Volume: 343, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-

2003
Respiratory responses evoked by blockades of ionotropic glutamate receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit.
    The European journal of neuroscience, 2005, Volume: 21, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bl

2005
Neurotransmitter mechanisms in the enhancement of the hypoxic ventilatory response by antecedent hyperoxia in the anesthetized rat.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2005, Volume: 56, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Dose-Response

2005
Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
    Journal of neurochemistry, 1995, Volume: 65, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Evoked Potential

1995
Effect of ibotenate on brain development: an excitotoxic mouse model of microgyria and posthypoxic-like lesions.
    Journal of neuropathology and experimental neurology, 1995, Volume: 54, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Alanine; Amino Acids; Animals; Brain; Brain Diseases; Embryonic and Fet

1995
Calcium-mediated damage following hypoxia in cerebral cortex ex vivo studied by NMR spectroscopy. Evidence for direct involvement of voltage-gated Ca(2+)-channels.
    Neurochemistry international, 1993, Volume: 23, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals;

1993
Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices.
    Neuroscience letters, 1994, Jan-17, Volume: 166, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Pote

1994
Development of vulnerability to hypoxic damage in in vitro hippocampal neurons.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1997, Volume: 15, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Disease Susceptibility; Embryo, Mammalian; Embryonic and Fetal

1997
Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons.
    Neuroscience research, 1998, Volume: 30, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Cell Membrane; Cobalt; Glucose; Hemoglobins; Hippoc

1998
Involvement of the glutamate transporter and the sodium-calcium exchanger in the hypoxia-induced increase in intracellular Ca2+ in rat hippocampal slices.
    Brain research, 1998, Dec-07, Volume: 813, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG;

1998
Late embryonic expression of AMPA receptor function in the CA1 region of the intact hippocampus in vitro.
    The European journal of neuroscience, 1999, Volume: 11, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Aging; Animals

1999
Responses to reversible anoxia of intracellular free and bound Ca(2+) in rat cortical slices.
    Resuscitation, 2000, Volume: 44, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chlortetracycline; Dizocilpine Maleate; Excitatory Am

2000
Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Female; GABA Antagonists; Hypothalamus; Hypoxia;

2001
The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia.
    Neuroscience letters, 1992, May-25, Volume: 139, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cold Temperature; Dextromethorphan; Guinea Pigs; Hippocampus;

1992
Medullary pathways for adrenocorticotropic hormone and vasopressin secretion in rabbits.
    The American journal of physiology, 1992, Volume: 262, Issue:6 Pt 2

    Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Animals; Cardiovascular System; Constricti

1992
Neurotoxicity of quinolinic acid and its derivatives in hypoxic rat hippocampal slices.
    Brain research, 1991, Dec-24, Volume: 568, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dose-Response Relationship, Drug; Hippocampus; Hypoxi

1991
Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen-Ion Conce

1990
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
    Experimental neurology, 1989, Volume: 103, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenz

1989
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
    Japanese journal of pharmacology, 1989, Volume: 50, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr

1989
Glutamate and anoxic neuronal death in vitro.
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cell Membrane Permeability; Ce

1986
Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia.
    Journal of neuroscience research, 2015, Volume: 93, Issue:5

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Dentate Gyrus;

2015
Early adenosine release contributes to hypoxia-induced disruption of stimulus-induced sharp wave-ripple complexes in rat hippocampal area CA3.
    The European journal of neuroscience, 2015, Volume: 42, Issue:2

    Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bicuculline; CA3 Region, Hippocampal; Excitat

2015
Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Disease Models, Animal; Excitatory Amino Acid Antagon

2008
Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure.
    Journal of neurophysiology, 2009, Volume: 101, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Conotoxins; Dose

2009
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-09, Volume: 31, Issue:6

    Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju

2011
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:4

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr

2012
Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex.
    Biochimica et biophysica acta, 2012, Volume: 1823, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhi

2012
Oxygen-sensitive reduction in Ca²⁺-activated K⁺ channel open probability in turtle cerebrocortex.
    Neuroscience, 2013, May-01, Volume: 237

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biophysics; Calcium; Cerebral Cortex; Dose-Response R

2013
Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances.
    Brain research, 2004, Aug-13, Volume: 1017, Issue:1-2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Carbonyl Cyanide p-Trifluoromethoxyphenyl

2004
The effects of corticotropin-releasing factor on anoxia-induced changes in evoked potentials in living slices of rat olfactory cortex.
    Neuroscience and behavioral physiology, 2004, Volume: 34, Issue:6

    Topics: Action Potentials; Animals; Corticotropin-Releasing Hormone; Electric Stimulation; Evoked Potentials

2004
Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels.
    Journal of neurophysiology, 2005, Volume: 94, Issue:2

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aniline Compounds; Animals; Calcium; Charybdotoxin; Cortical S

2005
Hypoxia recruits a respiratory-related excitatory pathway to brainstem premotor cardiac vagal neurons in animals exposed to prenatal nicotine.
    Neuroscience, 2005, Volume: 133, Issue:4

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Brain Stem; Drug

2005
Recruitment of excitatory serotonergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus post hypoxia and hypercapnia.
    Journal of neurophysiology, 2008, Volume: 99, Issue:3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Animals, Newborn; Drug Intera

2008