2-amino-5-phosphonovalerate has been researched along with Hypoxia in 36 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "To investigate the effects of 2-amino-5-phosphonovalerate-pharmacology (AP-V) and bicuculline on somatostatin (SST)-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia." | 7.71 | Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia. ( Fan, XT; Ruan, HZ; Wu, XG; Xu, HW; Zhang, JH, 2001) |
| "The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation." | 7.68 | The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992) |
| " We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)." | 3.78 | Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| "To investigate the effects of 2-amino-5-phosphonovalerate-pharmacology (AP-V) and bicuculline on somatostatin (SST)-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia." | 3.71 | Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia. ( Fan, XT; Ruan, HZ; Wu, XG; Xu, HW; Zhang, JH, 2001) |
| "The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation." | 3.68 | The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia. ( Giardina, WJ; Radek, RJ, 1992) |
| "In the excised patch configuration anoxia had no effect on K(Ca) channel open probability (P(open)); however, in cell-attached mode, there was a reversible fivefold reduction in P(open) (from 0." | 1.39 | Oxygen-sensitive reduction in Ca²⁺-activated K⁺ channel open probability in turtle cerebrocortex. ( Buck, LT; Hogg, DW; Rodgers-Garlick, CI, 2013) |
| "Chemical anoxia induced by cyanide, rotenone or p-trifluoromethoxy-phenylhydrazone (FCCP) decreased pH(i) by >0." | 1.32 | Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances. ( Ballanyi, K; Raupach, T, 2004) |
| "Severe anoxia induces destabilisation of intracellular calcium homeostasis in neurones." | 1.31 | Responses to reversible anoxia of intracellular free and bound Ca(2+) in rat cortical slices. ( Lazarewicz, JW; Samoilov, MO; Semenov, DG; Zielonka, P, 2000) |
| "Brief anoxia (3 min) abolished EPSPs but reduced IPSPs by 64." | 1.29 | Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices. ( Krnjević, K; Zhu, PJ, 1994) |
| "After 10 min of anoxia the dentate granule cells recovered to 16 +/- 7% (mean +/- SE) of their preanoxic level when untreated and to 54 +/- 15% when treated with aminophosphonovaleric acid (APV)." | 1.28 | The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice. ( Chambers, G; Cottrell, JE; Kass, IS, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (8.33) | 18.7374 |
| 1990's | 12 (33.33) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 9 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandes, GG | 1 |
| Frias, AT | 1 |
| Spiacci, A | 1 |
| Pinheiro, LC | 1 |
| Tanus-Santos, JE | 1 |
| Zangrossi, H | 1 |
| Almado, CE | 1 |
| Leão, RM | 1 |
| Machado, BH | 1 |
| Mordel, J | 1 |
| Sheikh, A | 1 |
| Tsohataridis, S | 1 |
| Kanold, PO | 1 |
| Zehendner, CM | 1 |
| Luhmann, HJ | 1 |
| Hong, LZ | 1 |
| Chai, CY | 1 |
| Mutolo, D | 1 |
| Bongianni, F | 1 |
| Nardone, F | 1 |
| Pantaleo, T | 1 |
| Pokorski, M | 1 |
| Kolesnikova, E | 1 |
| Marczak, M | 1 |
| Budzińska, K | 1 |
| Maier, CM | 1 |
| Sun, GH | 1 |
| Kunis, DM | 1 |
| Giffard, RG | 1 |
| Steinberg, GK | 1 |
| Marret, S | 1 |
| Mukendi, R | 1 |
| Gadisseux, JF | 1 |
| Gressens, P | 1 |
| Evrard, P | 1 |
| Brooks, KJ | 1 |
| Kauppinen, RA | 1 |
| Zhu, PJ | 1 |
| Krnjević, K | 1 |
| Di Loreto, S | 1 |
| Balestrino, M | 1 |
| Onitsuka, M | 1 |
| Mihara, S | 1 |
| Yamamoto, S | 1 |
| Shigemori, M | 1 |
| Higashi, H | 1 |
| Yamaguchi, S | 1 |
| Endo, K | 1 |
| Kitajima, T | 1 |
| Ogata, H | 1 |
| Hori, Y | 1 |
| Diabira, D | 1 |
| Hennou, S | 1 |
| Chevassus-Au-Louis, N | 1 |
| Ben-Ari, Y | 1 |
| Gozlan, H | 1 |
| Semenov, DG | 1 |
| Samoilov, MO | 1 |
| Zielonka, P | 1 |
| Lazarewicz, JW | 1 |
| Fan, XT | 1 |
| Ruan, HZ | 1 |
| Xu, HW | 1 |
| Zhang, JH | 1 |
| Wu, XG | 1 |
| Radek, RJ | 1 |
| Giardina, WJ | 1 |
| Gieroba, ZJ | 1 |
| Fullerton, MJ | 1 |
| Funder, JW | 1 |
| Blessing, WW | 1 |
| Schurr, A | 1 |
| West, CA | 1 |
| Rigor, BM | 1 |
| Tombaugh, GC | 1 |
| Sapolsky, RM | 1 |
| Kass, IS | 1 |
| Chambers, G | 1 |
| Cottrell, JE | 1 |
| Nakanishi, H | 1 |
| Kamata, O | 1 |
| Katsuda, N | 1 |
| Rothman, SM | 1 |
| Wall, AM | 1 |
| Mukandala, G | 1 |
| Greig, NH | 1 |
| O'Connor, JJ | 1 |
| Jarosch, MS | 1 |
| Gebhardt, C | 1 |
| Fano, S | 1 |
| Huchzermeyer, C | 1 |
| Ul Haq, R | 1 |
| Behrens, CJ | 1 |
| Heinemann, U | 1 |
| McGuire, M | 1 |
| Liu, C | 1 |
| Cao, Y | 1 |
| Ling, L | 1 |
| Kamendi, HW | 2 |
| Cheng, Q | 2 |
| Dergacheva, O | 2 |
| Gorini, C | 2 |
| Jameson, HS | 2 |
| Wang, X | 2 |
| McIntosh, JM | 1 |
| Mendelowitz, D | 3 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Li, L | 1 |
| Yang, R | 1 |
| Sun, K | 1 |
| Bai, Y | 1 |
| Zhang, Z | 1 |
| Zhou, L | 1 |
| Qi, Z | 1 |
| Qi, J | 1 |
| Chen, L | 1 |
| Dong, Y | 1 |
| Zhang, W | 1 |
| Lai, B | 1 |
| Luan, WJ | 1 |
| Zhu, YH | 1 |
| Zhao, BQ | 1 |
| Zheng, P | 1 |
| Rodgers-Garlick, CI | 1 |
| Hogg, DW | 1 |
| Buck, LT | 1 |
| Raupach, T | 1 |
| Ballanyi, K | 1 |
| Lyubimov, YE | 1 |
| Emel'yanov, NA | 1 |
| Izvarina, NL | 1 |
| Hepp, S | 1 |
| Gerich, FJ | 1 |
| Müller, M | 1 |
| Evans, C | 1 |
| Wang, J | 1 |
| Neff, R | 1 |
| Frank, JG | 1 |
| Pinol, RA | 1 |
36 other studies available for 2-amino-5-phosphonovalerate and Hypoxia
| Article | Year |
|---|---|
Nitric oxide in the dorsal periaqueductal gray mediates the panic-like escape response evoked by exposure to hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Arginine; Escape Reaction; Hypothalamus; Hypoxia; Ma | 2019 |
Intrinsic properties of rostral ventrolateral medulla presympathetic and bulbospinal respiratory neurons of juvenile rats are not affected by chronic intermittent hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cervical Cord; Hypoxia; Male; | 2014 |
Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2016 |
Involvement of N-methyl-D-aspartate receptors in post-hypoxic depression of the dorsomedial medulla in cats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 2003 |
Respiratory responses evoked by blockades of ionotropic glutamate receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bl | 2005 |
Neurotransmitter mechanisms in the enhancement of the hypoxic ventilatory response by antecedent hyperoxia in the anesthetized rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Dose-Response | 2005 |
Neuroprotection by the N-methyl-D-aspartate receptor antagonist CGP 40116: in vivo and in vitro studies.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Evoked Potential | 1995 |
Effect of ibotenate on brain development: an excitotoxic mouse model of microgyria and posthypoxic-like lesions.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Amino Acids; Animals; Brain; Brain Diseases; Embryonic and Fet | 1995 |
Calcium-mediated damage following hypoxia in cerebral cortex ex vivo studied by NMR spectroscopy. Evidence for direct involvement of voltage-gated Ca(2+)-channels.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; | 1993 |
Anoxia selectively depresses excitatory synaptic transmission in hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Pote | 1994 |
Development of vulnerability to hypoxic damage in in vitro hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Disease Susceptibility; Embryo, Mammalian; Embryonic and Fetal | 1997 |
Nitric oxide contributes to irreversible membrane dysfunction caused by experimental ischemia in rat hippocampal CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Cell Membrane; Cobalt; Glucose; Hemoglobins; Hippoc | 1998 |
Involvement of the glutamate transporter and the sodium-calcium exchanger in the hypoxia-induced increase in intracellular Ca2+ in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Transport System X-AG; | 1998 |
Late embryonic expression of AMPA receptor function in the CA1 region of the intact hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Aging; Animals | 1999 |
Responses to reversible anoxia of intracellular free and bound Ca(2+) in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chlortetracycline; Dizocilpine Maleate; Excitatory Am | 2000 |
Effects of AP-V and bicuculline on somatostatin-positive neurons in hypothalamus of rats subjected to acute hypobaric hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Female; GABA Antagonists; Hypothalamus; Hypoxia; | 2001 |
The neuroprotective effects of dextromethorphan on guinea pig-derived hippocampal slices during hypoxia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cold Temperature; Dextromethorphan; Guinea Pigs; Hippocampus; | 1992 |
Medullary pathways for adrenocorticotropic hormone and vasopressin secretion in rabbits.
Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Animals; Cardiovascular System; Constricti | 1992 |
Neurotoxicity of quinolinic acid and its derivatives in hypoxic rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Dose-Response Relationship, Drug; Hippocampus; Hypoxi | 1991 |
Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen-Ion Conce | 1990 |
The N-methyl-D-aspartate antagonists aminophosphonovaleric acid and MK-801 reduce anoxic damage to dentate granule and CA1 pyramidal cells in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Anticonvulsants; Aspartic Acid; Dibenz | 1989 |
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr | 1989 |
Glutamate and anoxic neuronal death in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Cell Membrane Permeability; Ce | 1986 |
Tumor necrosis factor-α potentiates long-term potentiation in the rat dentate gyrus after acute hypoxia.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Dentate Gyrus; | 2015 |
Early adenosine release contributes to hypoxia-induced disruption of stimulus-induced sharp wave-ripple complexes in rat hippocampal area CA3.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bicuculline; CA3 Region, Hippocampal; Excitat | 2015 |
Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Disease Models, Animal; Excitatory Amino Acid Antagon | 2008 |
Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Conotoxins; Dose | 2009 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr | 2012 |
Two free radical pathways mediate chemical hypoxia-induced glutamate release in synaptosomes from the prefrontal cortex.
Topics: Adenosine Triphosphate; Animals; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhi | 2012 |
Oxygen-sensitive reduction in Ca²⁺-activated K⁺ channel open probability in turtle cerebrocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biophysics; Calcium; Cerebral Cortex; Dose-Response R | 2013 |
Intracellular pH and KATP channel activity in dorsal vagal neurons of juvenile rats in situ during metabolic disturbances.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Carbonyl Cyanide p-Trifluoromethoxyphenyl | 2004 |
The effects of corticotropin-releasing factor on anoxia-induced changes in evoked potentials in living slices of rat olfactory cortex.
Topics: Action Potentials; Animals; Corticotropin-Releasing Hormone; Electric Stimulation; Evoked Potentials | 2004 |
Sulfhydryl oxidation reduces hippocampal susceptibility to hypoxia-induced spreading depression by activating BK channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aniline Compounds; Animals; Calcium; Charybdotoxin; Cortical S | 2005 |
Hypoxia recruits a respiratory-related excitatory pathway to brainstem premotor cardiac vagal neurons in animals exposed to prenatal nicotine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Animals, Newborn; Brain Stem; Drug | 2005 |
Recruitment of excitatory serotonergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus post hypoxia and hypercapnia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Triphosphate; Animals; Animals, Newborn; Drug Intera | 2008 |