2-amino-5-phosphonovalerate has been researched along with Hypoxia-Ischemia, Brain in 4 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Each of these could also contribute to cerebral edema, which is the primary cause of patient mortality after stroke." | 1.32 | Brain edema induced by in vitro ischemia: causal factors and neuroprotection. ( Avshalumov, MV; MacGregor, DG; Rice, ME, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| MacGregor, DG | 1 |
| Avshalumov, MV | 1 |
| Rice, ME | 1 |
| Panigrahy, A | 1 |
| Rosenberg, PA | 1 |
| Assmann, S | 1 |
| Foley, EC | 1 |
| Kinney, HC | 1 |
| Nagy, JI | 1 |
| Li, WE | 1 |
| Hamann, M | 1 |
| Rossi, DJ | 1 |
| Marie, H | 1 |
| Attwell, D | 1 |
4 other studies available for 2-amino-5-phosphonovalerate and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
Brain edema induced by in vitro ischemia: causal factors and neuroprotection.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antioxidants; Brain Edem | 2003 |
Differential expression of glutamate receptor subtypes in human brainstem sites involved in perinatal hypoxia-ischemia.
Topics: 2-Amino-5-phosphonovalerate; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; | 2000 |
A brain slice model for in vitro analyses of astrocytic gap junction and connexin43 regulation: actions of ischemia, glutamate and elevated potassium.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Brain; Connexin 43; Gap Junctions; Glutamic Acid; | 2000 |
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizo | 2002 |