2-amino-5-phosphonovalerate has been researched along with Hypertension in 10 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rilmenidine is a second-generation centrally acting antihypertensive drug that acts mainly through the activation of the imidazoline (I(1)) receptor in the rostral ventrolateral medulla (RVLM)." | 1.31 | The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats. ( Abdel-Rahman, AA; Zhang, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takakura, AC | 1 |
| Colombari, E | 1 |
| Menani, JV | 1 |
| Moreira, TS | 1 |
| Zhang, J | 1 |
| Abdel-Rahman, AA | 1 |
| Li, DP | 2 |
| Pan, HL | 2 |
| Lin, JC | 1 |
| Tsao, WL | 1 |
| Wang, Y | 2 |
| Maiorov, DN | 1 |
| Krenz, NR | 1 |
| Krassioukov, AV | 1 |
| Weaver, LC | 1 |
| Maione, S | 1 |
| Vitagliano, S | 1 |
| Berrino, L | 2 |
| Lampa, E | 1 |
| Rossi, F | 2 |
| Mills, E | 1 |
| Minson, J | 1 |
| Drolet, G | 1 |
| Chalmers, J | 1 |
| Kao, MC | 1 |
| Lee, HK | 1 |
| Chai, CY | 1 |
| Ye, ZY | 1 |
| Li, L | 1 |
| D'Amico, M | 1 |
| Pizzirusso, A | 1 |
| de Novellis, V | 1 |
10 other studies available for 2-amino-5-phosphonovalerate and Hypertension
| Article | Year |
|---|---|
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemor | 2011 |
The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hem | 2002 |
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Excitato | 2007 |
Cardiovascular effects of NMDA in the RVLM of spontaneously hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Carotid Arteries; Electric Stimulation; Hemody | 1995 |
Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bloo | 1997 |
Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Blood Pressure; Cerebral Ventricles; Clo | 1992 |
Effect of intrathecal amino acid receptor antagonists on basal blood pressure and pressor responses to brainstem stimulation in normotensive and hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Stem; Cerebrovascular Disor | 1990 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occl | 1991 |
Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.
Topics: Animals; Benzimidazoles; Blood Pressure; Brain Stem; Casein Kinase II; Dichlororibofuranosylbenzimid | 2011 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycl | 1996 |