2-amino-5-phosphonovalerate has been researched along with Genetic Predisposition in 2 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Excerpt | Relevance | Reference |
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"Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 7.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
"Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 3.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
Timeframe | Studies, this research(%) | All Research% |
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pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (50.00) | 18.2507 |
2000's | 1 (50.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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De Sarro, G | 1 |
De Sarro, A | 1 |
Ammendola, D | 1 |
Patel, S | 1 |
Ravizza, T | 1 |
Moneta, D | 1 |
Bottazzi, B | 1 |
Peri, G | 1 |
Garlanda, C | 1 |
Hirsch, E | 1 |
Richards, GJ | 1 |
Mantovani, A | 1 |
Vezzani, A | 1 |
2 other studies available for 2-amino-5-phosphonovalerate and Genetic Predisposition
Article | Year |
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Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance; | 1996 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; | 2001 |