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2-amino-5-phosphonovalerate and Genetic Predisposition

2-amino-5-phosphonovalerate has been researched along with Genetic Predisposition in 2 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
"Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration."7.69Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996)
"Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration."3.69Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Sarro, G1
De Sarro, A1
Ammendola, D1
Patel, S1
Ravizza, T1
Moneta, D1
Bottazzi, B1
Peri, G1
Garlanda, C1
Hirsch, E1
Richards, GJ1
Mantovani, A1
Vezzani, A1

Other Studies

2 other studies available for 2-amino-5-phosphonovalerate and Genetic Predisposition

ArticleYear
Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
    Brain research, 1996, Sep-23, Volume: 734, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance;

1996
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
    Neuroscience, 2001, Volume: 105, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists;

2001