2-amino-5-phosphonovalerate has been researched along with Fragile X Syndrome in 2 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Fragile X Syndrome: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nosyreva, ED | 1 |
| Huber, KM | 1 |
| Yau, SY | 1 |
| Bostrom, CA | 1 |
| Chiu, J | 1 |
| Fontaine, CJ | 1 |
| Sawchuk, S | 1 |
| Meconi, A | 1 |
| Wortman, RC | 1 |
| Truesdell, E | 1 |
| Truesdell, A | 1 |
| Chiu, C | 1 |
| Hryciw, BN | 1 |
| Eadie, BD | 1 |
| Ghilan, M | 1 |
| Christie, BR | 1 |
2 other studies available for 2-amino-5-phosphonovalerate and Fragile X Syndrome
| Article | Year |
|---|---|
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anisomycin; Blotting, Western; Disease Models, Animal; Drug In | 2006 |
Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Estrous Cycle; Female; Fragile X Mental Retardation | 2016 |