2-amino-5-phosphonovalerate has been researched along with Experimental High Pressure Neurological Syndrome in 9 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These effects, termed high pressure neurological syndrome (HPNS), appear at pressure above 1." | 1.36 | The efficacy of physiological and pharmacological N-methyl-D-aspartate receptor block is greatly reduced under hyperbaric conditions. ( Grossman, Y; Mor, A, 2010) |
| "HPNS is characterized by tremor, sleep disorders, electroencephalographic changes, and impairment of cognitive and motor performances." | 1.33 | Modulation of isolated N-methyl-d-aspartate receptor response under hyperbaric conditions. ( Grossman, Y; Mor, A, 2006) |
| "4." | 1.29 | Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome. ( Bowser-Riley, F; Davies, SN; Shuker, MA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mor, A | 2 |
| Grossman, Y | 2 |
| Pearce, PC | 1 |
| Halsey, MJ | 4 |
| Maclean, CJ | 1 |
| Ward, EM | 1 |
| Pearson, J | 1 |
| Henley, M | 1 |
| Meldrum, BS | 4 |
| Shuker, MA | 1 |
| Bowser-Riley, F | 1 |
| Davies, SN | 1 |
| Darbin, O | 2 |
| Risso, JJ | 2 |
| Rostain, JC | 3 |
| Millan, MH | 2 |
| Wardley-Smith, B | 3 |
9 other studies available for 2-amino-5-phosphonovalerate and Experimental High Pressure Neurological Syndrome
| Article | Year |
|---|---|
The efficacy of physiological and pharmacological N-methyl-D-aspartate receptor block is greatly reduced under hyperbaric conditions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Atmosphere Exposure Chambers; Dose-Response Relationship, Drug | 2010 |
The orally active NMDA receptor antagonist CGP 39551 ameliorates the high pressure neurological syndrome in Papio anubis.
Topics: 2-Amino-5-phosphonovalerate; Administration, Oral; Animals; Anticonvulsants; Electroencephalography; | 1993 |
Possible NMDA antagonist properties of drugs that affect high pressure neurological syndrome.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Alkaloids; Animals; Benzimidazoles; High Pressure Ne | 1994 |
The full expression of locomotor and motor hyperactivities induced by pressure requires both striatal dopaminergic and N-methyl-D-aspartate receptor activities in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzazepines; Corpus Striatum; Dopamine Antagonists; Dopamine | 1999 |
High pressure enhanced NMDA activity in the striatum and the globus pallidus: relationships with myoclonia and locomotor and motor activity in rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Atmospheric Pressure; Corpus Striatum; Excita | 2000 |
Brain nuclei and neurotransmitters involved in the regulation of the high pressure neurological syndrome in the rat.
Topics: 2-Amino-5-phosphonovalerate; 2-Chloroadenosine; Acetylcholine; Amino Acids; Animals; Body Temperatur | 1991 |
Effect of NMDA and 2-amino-7-phosphonoheptanoate focal injection into the ventrolateral thalamic nucleus on the high pressure neurological syndrome in the rat.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Central Nervous System Diseases; H | 1990 |
Effect of 2-aminophosphonoheptanoic acid on the EEG of rats exposed to high pressure.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Central Nervous System Dise | 1986 |
Modulation of isolated N-methyl-d-aspartate receptor response under hyperbaric conditions.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radia | 2006 |