2-amino-5-phosphonovalerate has been researched along with Epilepsy in 134 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 7.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
| " Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques." | 7.68 | Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Systemic administration of kainic acid results in the development of a characteristic convulsive syndrome, accompanied by neuropathological alterations and loss of transmitter markers in some forebrain regions." | 7.68 | Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers. ( Barnabei, O; Contestabile, A; Migani, P; Virgili, M, 1992) |
| " Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively." | 4.77 | Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Two selective excitatory amino acid antagonists, DL-(E)-2-amino-4-methyl- 5-phosphono-3-pentenoic acid (CGP 37849) and its carboxyethylester (CGP 39551), were studied against audiogenic seizures in genetically epilepsy-prone rats following oral administration." | 3.69 | Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats. ( Ammendola, D; De Sarro, A; De Sarro, G; Patel, S, 1996) |
| " Bicuculline-induced epileptiform bursts in slices of neocortical tissue resected from children (3 mo to 14 yr) undergoing neurosurgical treatment for intractable epilepsy were studied with conventional intracellular recording techniques." | 3.68 | Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy. ( Dudek, FE; Kim, YI; Peacock, WJ, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Systemic administration of kainic acid results in the development of a characteristic convulsive syndrome, accompanied by neuropathological alterations and loss of transmitter markers in some forebrain regions." | 3.68 | Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers. ( Barnabei, O; Contestabile, A; Migani, P; Virgili, M, 1992) |
| "The effects of ketamine and (+)cyclazocine on three in vitro models of epilepsy: the "Mg2+ free", the 4-aminopyridine (4-AP) and, for comparison, the penicillin model were studied." | 3.67 | Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats. ( de Carolis, AS; Frank, C; Sagratella, S, 1987) |
| " In contrast, in human neocortical preparations obtained from epilepsy surgery, in approximately 20% of the slices spontaneous epileptiform activity appeared with this bicuculline dosage without SDs." | 1.32 | Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue. ( Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H, 2003) |
| "Limbic epilepsy is a chronic condition associated with a broad zone of seizure onset and pathology." | 1.31 | Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy. ( Bertram, EH; Mangan, PS; Scott, CA; Williamson, JM, 2000) |
| "Chlormethiazole has sedative, hypnotic, anticonvulsant and neuroprotective properties." | 1.31 | Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function. ( Empson, RM; Gee, VJ; Newberry, NR; Sheardown, MJ, 2000) |
| " Evoked inhibitory postsynaptic currents (IPSCs) were decreased by kainate by up to 90%, showing a bell-shaped dose-response curve similar to that of native kainate-selective receptors." | 1.30 | Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus. ( Herreras, O; Lerma, J; Rodríguez-Moreno, A, 1997) |
| "Trimipramine has been classified as an atypical tricyclic antidepressant, because only weak inhibitory effects on serotonin and/or noradrenaline reuptake have been found." | 1.30 | Effects of the atypical antidepressant trimipramine on field potentials in the low Mg2+-model in guinea pig hippocampal slices. ( Berger, M; Langosch, JM; Repp, M; Walden, J, 1998) |
| "In this study, the anticonvulsant and adverse effects of compounds that belong to four different categories of systemically available N-methyl-D-aspartate (NMDA) receptor ligands were compared, namely the competitive antagonist CGP 40116, the noncompetitive antagonist MK-801 (dizocilpine), the glycineB receptor antagonist L-701,324, and the glycineB receptor high-efficacy partial agonist D-cycloserine." | 1.30 | Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists. ( Wlaź, P, 1998) |
| "Pregnancy is associated with a significant alteration of NMDA and non-NMDA receptor binding in rats." | 1.30 | N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats. ( Standley, CA, 1999) |
| "These seizure-like events (SLEs) comprised three distinct phases, called here primary, secondary, and tertiary bursts." | 1.30 | Seizure-like events in disinhibited ventral slices of adult rat hippocampus. ( Borck, C; Jefferys, JG, 1999) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| " A dose-response relation for NMDA activation indicated that bath application of 1 and 5 microM NMDA had little or no effect on the response to a paired stimulus pulse (triggered response) and did not induce spontaneous bursting." | 1.27 | The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice. ( Anderson, WW; Swartzwelder, HS; Wilson, WA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (14.93) | 18.7374 |
| 1990's | 64 (47.76) | 18.2507 |
| 2000's | 42 (31.34) | 29.6817 |
| 2010's | 8 (5.97) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Punnakkal, P | 1 |
| Dominic, D | 1 |
| Fuortes, MG | 1 |
| Faria, LC | 1 |
| Merlin, LR | 2 |
| Carriero, G | 1 |
| Uva, L | 1 |
| Gnatkovsky, V | 1 |
| Avoli, M | 5 |
| de Curtis, M | 1 |
| Kovács, Z | 1 |
| Czurkó, A | 1 |
| Kékesi, KA | 1 |
| Juhász, G | 1 |
| Kernig, K | 1 |
| Kirschstein, T | 1 |
| Würdemann, T | 1 |
| Rohde, M | 1 |
| Köhling, R | 3 |
| Cunningham, MO | 2 |
| Roopun, A | 1 |
| Schofield, IS | 1 |
| Whittaker, RG | 1 |
| Duncan, R | 1 |
| Russell, A | 1 |
| Jenkins, A | 1 |
| Nicholson, C | 1 |
| Whittington, MA | 2 |
| Traub, RD | 2 |
| Gulyás-Kovács, A | 1 |
| Dóczi, J | 1 |
| Tarnawa, I | 1 |
| Détári, L | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Világi, I | 1 |
| Uusisaari, M | 1 |
| Smirnov, S | 1 |
| Voipio, J | 1 |
| Kaila, K | 1 |
| Koch, UR | 1 |
| Hagemann, G | 1 |
| Redecker, C | 1 |
| Straub, H | 2 |
| Speckmann, EJ | 3 |
| Zhang, DX | 1 |
| Bertram, EH | 2 |
| Roshan-Milani, S | 1 |
| Ferrigan, L | 1 |
| Khoshnood, MJ | 1 |
| Davies, CH | 3 |
| Cobb, SR | 2 |
| Verleye, M | 1 |
| André, N | 1 |
| Heulard, I | 1 |
| Gillardin, JM | 1 |
| Campbell, SL | 1 |
| Hablitz, JJ | 6 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 1 |
| Zhang, L | 1 |
| Carlen, PL | 1 |
| Feng, Z | 1 |
| Durand, DM | 1 |
| Slamberová, R | 1 |
| Mares, P | 2 |
| Raisinghani, M | 1 |
| Faingold, CL | 1 |
| Papatheodoropoulos, C | 1 |
| Moschovos, C | 1 |
| Kostopoulos, G | 1 |
| Kang, N | 1 |
| Xu, J | 1 |
| Xu, Q | 1 |
| Nedergaard, M | 1 |
| Kang, J | 1 |
| Lees, G | 1 |
| Stöhr, T | 1 |
| Errington, AC | 1 |
| Salamoni, SD | 1 |
| da Costa, JC | 1 |
| Palma, MS | 1 |
| Konno, K | 1 |
| Nihei, K | 1 |
| Azambuja, NA | 1 |
| Neto, EP | 1 |
| Venturin, GT | 1 |
| Tavares, AA | 1 |
| de Abreu, DS | 1 |
| Breda, RV | 1 |
| Gill, CH | 1 |
| Brown, JT | 2 |
| Shivji, N | 1 |
| Lappin, SC | 1 |
| Farmer, C | 1 |
| Randall, A | 2 |
| McNaughton, NC | 1 |
| Skov, J | 1 |
| Andreasen, M | 1 |
| Nedergaard, S | 1 |
| Schiller, Y | 1 |
| Bankirer, Y | 1 |
| Glasscock, E | 1 |
| Qian, J | 1 |
| Yoo, JW | 1 |
| Noebels, JL | 1 |
| Peterson, DW | 1 |
| Collins, JF | 1 |
| Bradford, HF | 1 |
| Dudek, FE | 5 |
| Wuarin, JP | 3 |
| Tasker, JG | 2 |
| Kim, YI | 3 |
| Peacock, WJ | 4 |
| Zhang, CL | 1 |
| Gloveli, T | 2 |
| Heinemann, U | 7 |
| Fueta, Y | 1 |
| Siniscalchi, A | 2 |
| Tancredi, V | 2 |
| Stasheff, SF | 2 |
| Mott, DD | 1 |
| Wilson, WA | 3 |
| Empson, RM | 2 |
| Jefferys, JG | 4 |
| Lahtinen, H | 1 |
| Ylinen, A | 1 |
| Hyvönen, M | 1 |
| Sirviö, J | 1 |
| Miettinen, R | 1 |
| Riekkinen, PJ | 1 |
| Yamada, N | 1 |
| Bilkey, DK | 1 |
| Piguet, P | 1 |
| Leschinger, A | 1 |
| Stabel, J | 1 |
| Igelmund, P | 1 |
| Gaiarsa, JL | 1 |
| Zagrean, L | 1 |
| Ben-Ari, Y | 2 |
| Loeb, C | 2 |
| Patrone, A | 2 |
| Besio, G | 2 |
| Balestrino, M | 2 |
| Mainardi, P | 2 |
| Schneiderman, JH | 2 |
| Sterling, CA | 1 |
| Luo, R | 1 |
| Scharfman, HE | 1 |
| Müller, M | 1 |
| Gähwiler, BH | 1 |
| Rietschin, L | 1 |
| Thompson, SM | 1 |
| Gean, PW | 4 |
| Chang, FC | 2 |
| Hung, CR | 1 |
| Watts, AE | 1 |
| Smith, SE | 1 |
| al-Zubaidy, ZA | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 3 |
| Isokawa, M | 2 |
| Fried, I | 1 |
| De Sarro, G | 3 |
| De Sarro, A | 2 |
| Ammendola, D | 1 |
| Patel, S | 3 |
| Calabresi, P | 1 |
| Mercuri, NB | 1 |
| Bernardi, G | 1 |
| Rodríguez-Moreno, A | 1 |
| Herreras, O | 1 |
| Lerma, J | 1 |
| Patrylo, PR | 1 |
| Rutecki, PA | 1 |
| Yang, Y | 1 |
| Shoji, Y | 1 |
| Tanaka, E | 2 |
| Yamamoto, S | 1 |
| Maeda, H | 1 |
| Higashi, H | 2 |
| Langosch, JM | 1 |
| Repp, M | 1 |
| Berger, M | 1 |
| Walden, J | 1 |
| Wlaź, P | 1 |
| DeFazio, T | 1 |
| Kapur, A | 1 |
| Haberly, LB | 1 |
| DeLorenzo, RJ | 1 |
| Pal, S | 1 |
| Sombati, S | 1 |
| Faingold, C | 1 |
| Casebeer, D | 1 |
| Standley, CA | 1 |
| Borck, C | 1 |
| Egorov, AV | 1 |
| Schmitz, D | 1 |
| Müller, W | 1 |
| Telfeian, AE | 1 |
| Connors, BW | 1 |
| Xiong, ZQ | 1 |
| Stringer, JL | 1 |
| DeFazio, RA | 1 |
| Folbergrová, J | 1 |
| Haugvicová, R | 1 |
| Keele, NB | 1 |
| Zinebi, F | 1 |
| Neugebauer, V | 1 |
| Shinnick-Gallagher, P | 2 |
| Galoyan, SM | 1 |
| Fornai, F | 1 |
| Bassi, L | 1 |
| Gesi, M | 1 |
| Giorgi, FS | 1 |
| Guerrini, R | 1 |
| Bonaccorsi, I | 1 |
| Alessandrì, MG | 1 |
| Leresche, N | 1 |
| Asprodini, E | 1 |
| Emri, Z | 1 |
| Cope, DW | 1 |
| Crunelli, V | 1 |
| Sanna, PP | 1 |
| Berton, F | 1 |
| Cammalleri, M | 1 |
| Tallent, MK | 1 |
| Siggins, GR | 1 |
| Bloom, FE | 1 |
| Francesconi, W | 1 |
| Luhmann, HJ | 1 |
| Dzhala, VI | 1 |
| Dhillon, A | 1 |
| Jones, RS | 4 |
| Gutiérrez, R | 1 |
| Ravizza, T | 1 |
| Moneta, D | 1 |
| Bottazzi, B | 1 |
| Peri, G | 1 |
| Garlanda, C | 1 |
| Hirsch, E | 1 |
| Richards, GJ | 1 |
| Mantovani, A | 1 |
| Vezzani, A | 1 |
| Woodhall, G | 1 |
| Evans, DI | 1 |
| Sancini, G | 1 |
| Franceschetti, S | 1 |
| Lavazza, T | 1 |
| Panzica, F | 1 |
| Cipelletti, B | 1 |
| Frassoni, C | 1 |
| Spreafico, R | 1 |
| Acampora, D | 1 |
| Avanzini, G | 1 |
| Gorji, A | 2 |
| Jauch, R | 1 |
| Windmüller, O | 1 |
| Lehmann, TN | 1 |
| Gabriel, S | 1 |
| Avshalumov, MV | 1 |
| Rice, ME | 1 |
| Cook, CJ | 1 |
| Devine, CE | 1 |
| Tavener, A | 1 |
| Gilbert, KV | 1 |
| Virgili, M | 1 |
| Migani, P | 1 |
| Contestabile, A | 1 |
| Barnabei, O | 1 |
| Williamson, R | 3 |
| Wheal, HV | 4 |
| Shin, C | 1 |
| Tamaki, Y | 1 |
| Wilson, JT | 1 |
| Butler, L | 1 |
| Sakaguchi, T | 1 |
| Gale, K | 1 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Lee, WL | 3 |
| Hwa, GG | 2 |
| Oliver, A | 1 |
| Villemure, JG | 2 |
| Nishi, S | 1 |
| Bawin, SM | 1 |
| Satmary, WM | 1 |
| Mahoney, MD | 1 |
| Adey, WR | 1 |
| Mello, LE | 1 |
| Simpson, LH | 1 |
| Drapeau, C | 1 |
| Louvel, J | 1 |
| Pumain, R | 1 |
| Olivier, A | 1 |
| Urban, L | 1 |
| Aitken, PG | 1 |
| Friedman, A | 2 |
| Somjen, GG | 1 |
| Lambert, JD | 1 |
| Watson, GB | 2 |
| Lanthorn, TH | 2 |
| Shupliakov, OV | 1 |
| Veskov, R | 1 |
| Veselkin, NP | 1 |
| Rakich, L | 1 |
| Cepeda, C | 1 |
| Walsh, JP | 1 |
| Buchwald, NA | 1 |
| Chou, SM | 1 |
| Dreier, JP | 1 |
| Millan, MH | 1 |
| Wardley-Smith, B | 1 |
| Dürmüller, N | 1 |
| Peeters, BW | 1 |
| van Rijn, CM | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Rader, RK | 1 |
| McBain, CJ | 1 |
| Boden, P | 1 |
| Hill, RG | 1 |
| Nakanishi, H | 1 |
| Kamata, O | 1 |
| Katsuda, N | 1 |
| Anderson, WW | 2 |
| Clark, S | 1 |
| MacDonald, JF | 1 |
| Slater, NT | 1 |
| Stelzer, A | 1 |
| Galvan, M | 1 |
| Herron, CE | 1 |
| Collingridge, GL | 2 |
| Ashwood, TJ | 2 |
| Baldino, F | 1 |
| Wolfson, B | 1 |
| Gutnick, MJ | 1 |
| King, GL | 1 |
| Dingledine, R | 1 |
| Swartzwelder, HS | 1 |
| Sagratella, S | 1 |
| Frank, C | 1 |
| de Carolis, AS | 1 |
| Stone, TW | 1 |
| Aram, JA | 1 |
| Lodge, D | 1 |
| Meldrum, B | 1 |
| Millan, M | 1 |
| Kiese, K | 1 |
| Jablonski, J | 1 |
| Hackenbracht, J | 1 |
| Wrosch, JK | 1 |
| Groemer, TW | 1 |
| Kornhuber, J | 1 |
| Blümcke, I | 1 |
| Kobow, K | 1 |
| Nichols, J | 1 |
| Perez, R | 1 |
| Wu, C | 1 |
| Adelson, PD | 1 |
| Anderson, T | 1 |
| Lopantsev, V | 1 |
| Both, M | 1 |
| Draguhn, A | 1 |
| Ketzef, M | 1 |
| Kahn, J | 1 |
| Weissberg, I | 1 |
| Becker, AJ | 1 |
| Gitler, D | 1 |
| Albensi, BC | 1 |
| Ata, G | 1 |
| Schmidt, E | 1 |
| Waterman, JD | 1 |
| Janigro, D | 1 |
| Rüschenschmidt, C | 1 |
| Schwarz, M | 1 |
| Siep, E | 1 |
| Ebner, A | 1 |
| Pannek, HW | 1 |
| Tuxhorn, I | 1 |
| Wolf, P | 1 |
| Thuault, SJ | 1 |
| Calver, AR | 1 |
| Mangan, PS | 1 |
| Scott, CA | 1 |
| Williamson, JM | 1 |
| Gee, VJ | 1 |
| Sheardown, MJ | 1 |
| Newberry, NR | 1 |
1 review available for 2-amino-5-phosphonovalerate and Epilepsy
| Article | Year |
|---|---|
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su | 1988 |
133 other studies available for 2-amino-5-phosphonovalerate and Epilepsy
| Article | Year |
|---|---|
NMDA Receptor GluN2 Subtypes Control Epileptiform Events in the Hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Dentat | 2018 |
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; | 2008 |
Independent epileptiform discharge patterns in the olfactory and limbic areas of the in vitro isolated Guinea pig brain during 4-aminopyridine treatment.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Brain; Cerebral Cortex; Entorhinal Cortex; Ep | 2010 |
Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyt | 2011 |
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; CA1 R | 2012 |
Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adult; Animals; Axons; Computer Simulation; Cortical | 2012 |
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicucul | 2002 |
Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Carbonic Anhydrase Inhibitors; Electric Stimulation; Electroph | 2002 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; D | 2003 |
Different reactions of control and epileptic rats to administration of APV or muscimol on thalamic or CA3-induced CA1 responses.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Male; Muscimol; Rats; Rats, Sprag | 2003 |
Regulation of epileptiform activity in hippocampus by nicotinic acetylcholine receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Action Potentials; Analysis of Variance; Animals; Bicu | 2003 |
Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, N | 2004 |
Glutamate transporters regulate excitability in local networks in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Bicuculline; | 2004 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
Suppression of excitatory synaptic transmission can facilitate low-calcium epileptiform activity in the hippocampus in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cadmium; Calcium; Chelating Agents; Egtazic Acid; Epilepsy; Ex | 2004 |
Cortical epileptic afterdischarges in immature rats are differently influenced by NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Ep | 2005 |
Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Analysis of Variance; Animals; | 2005 |
Greater contribution of N-methyl-D-aspartic acid receptors in ventral compared to dorsal hippocampal slices in the expression and long-term maintenance of epileptiform activity.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsy | 2005 |
Astrocytic glutamate release-induced transient depolarization and epileptiform discharges in hippocampal CA1 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals | 2005 |
Stereoselective effects of the novel anticonvulsant lacosamide against 4-AP induced epileptiform activity in rat visual cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetamides; Anim | 2006 |
The antiepileptic activity of JSTX-3 is mediated by N-methyl-D-aspartate receptors in human hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Adolescent; Adult; Anticonvulsants; Child; Electroph | 2005 |
Inhibition of Ih reduces epileptiform activity in rodent hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Animals, Newborn; Bicuculline; Dose-Respons | 2006 |
Postnatal development of a new type of epileptiform activity in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; | 2006 |
Cellular mechanisms underlying antiepileptic effects of low- and high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Va | 2007 |
Masking epilepsy by combining two epilepsy genes.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Typ | 2007 |
The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminobutyrates; Amygdala; Animals; Anticonvulsants; Epilep | 1983 |
Neurophysiology of neocortical slices resected from children undergoing surgical treatment for epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Cerebral Cortex; Child; Child, Preschool; Electrophysiology | 1995 |
Effects of NMDA- and AMPA-receptor antagonists on different forms of epileptiform activity in rat temporal cortex slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dextrorphan; Epilepsy; E | 1994 |
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampu | 1995 |
Axon terminal hyperexcitability associated with epileptogenesis in vitro. II. Pharmacological regulation by NMDA and GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Baclofen; Culture Techniques; Epilepsy; Evoked Potentia | 1993 |
Synaptic inhibition in primary and secondary chronic epileptic foci induced by intrahippocampal tetanus toxin in the rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Electrophysiolo | 1993 |
Preservation of hippocampal NMDA receptors may be crucial for spatial learning after epileptic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Electric Stimulation; Epilepsy; Glutamate | 1993 |
Induction of trypsin-induced hyperexcitability in the rat hippocampal slice is blocked by the N-methyl-D-aspartate receptor antagonist, MK-801.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electrophysiology; Epilepsy; Hippocampus; | 1993 |
GABAA- and GABAB-mediated inhibition in the rat dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1993 |
Pharmacological and electrographic properties of epileptiform activity induced by elevated K+ and lowered Ca2+ and Mg2+ concentration in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Carbachol; Elec | 1993 |
Properties and synaptic mechanisms of bicuculline-induced epileptiform bursts in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Cerebral Cortex; Child; Child, Preschool; Cult | 1993 |
Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 1994 |
The antiepileptic effect of low-dose amino-phosphono-valeric acid (APV) is not enhanced by phosphatidylserine association.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Drug Synergism; Electroencep | 1993 |
Hippocampal plasticity following epileptiform bursting produced by GABAA antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Evoked Potentials; GABA Antago | 1994 |
EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Atropine; Epilepsy; Evok | 1994 |
Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 1993 |
Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Animals; Bicuculline; Electrophysiology; E | 1993 |
Epileptic focus induced in rat by intrahippocampal cholera toxin: neuronal properties in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclo | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Extracellular slow negative transient in the dentate gyrus of human epileptic hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Adult; Bicuculline; Dentate Gyrus; Electric Stimulation; Electroencepha | 1996 |
Lack of development of tolerance to anticonvulsant effects of two excitatory amino acid antagonists, CGP [corrected] 37849 and CGP 39551 in genetically epilepsy-prone rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Administration Schedule; Drug Tolerance; | 1996 |
Epileptiform discharge induced by 4-aminopyridine in magnesium-free medium in neocortical neurons: physiological and pharmacological characterization.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, | 1997 |
Kainate receptors presynaptically downregulate GABAergic inhibition in the rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Cells, Cult | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysi | 1998 |
Ictal epileptiform activity in the CA3 region of hippocampal slices produced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electrophysiology; Epilepsy; Extracellular Space; GABA Agonist | 1998 |
Mechanisms underlying the enhancement of excitatory synaptic transmission in basolateral amygdala neurons of the kindling rat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Baclofen; Bicu | 1998 |
Effects of the atypical antidepressant trimipramine on field potentials in the low Mg2+-model in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Antidepressive Agents, Tricyclic; Calcium C | 1998 |
Anti-convulsant and adverse effects of the glycineB receptor ligands, D-cycloserine and L-701,324: comparison with competitive and non-competitive N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Antimetabolites; Avoidance Learning; Binding, | 1998 |
Excitability changes in freeze-induced neocortical microgyria.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Brain; | 1998 |
'Dormant' inhibitory neurons: do they exist and what is their functional impact?
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 1998 |
Duration of NMDA-dependent synaptic potentiation in piriform cortex in vivo is increased after epileptiform bursting.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Electric Stimulation; Electrophysiology; | 1998 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocil | 1998 |
Modulation of the audiogenic seizure network by noradrenergic and glutamatergic receptors of the deep layers of superior colliculus.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Adrenergic alpha-Agonists; Animals; Epilepsy; Exc | 1999 |
N-methyl-D-aspartate receptor binding is altered and seizure potential reduced in pregnant rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Conv | 1999 |
Seizure-like events in disinhibited ventral slices of adult rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked Potentials | 1999 |
Carbachol-induced changes in excitability and [Ca2+]i signalling in projection cells of medial entorhinal cortex layers II and III.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Calcium; Calcium Signali | 1999 |
Epileptiform propagation patterns mediated by NMDA and non-NMDA receptors in rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dose-Response Relationsh | 1999 |
Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cesium; | 1999 |
Alterations in NMDA receptors in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Epilepsy; Evoked Potentials; Excitator | 2000 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Epileptogenesis up-regulates metabotropic glutamate receptor activation of sodium-calcium exchange current in the amygdala.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Calcium; Dose- | 2000 |
Long-lasting potentiation of epileptiform bursts by group I mGluRs is NMDA receptor independent.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Convulsants; Epilepsy; Excitatory Amino Aci | 2000 |
Similar increases in extracellular lactic acid in the limbic system during epileptic and/or olfactory stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Convulsants; Denervation; Dose-Response Relationship, Drug; Ep | 2000 |
Somatostatin inhibits GABAergic transmission in the sensory thalamus via presynaptic receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; C | 2000 |
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Electrophysiology; Enzyme Inhibitors; Epileps | 2000 |
Generation and propagation of 4-AP-induced epileptiform activity in neonatal intact limbic structures in vitro.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potential | 2000 |
Laminar differences in recurrent excitatory transmission in the rat entorhinal cortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Entor | 2000 |
Kindling induces transient fast inhibition in the dentate gyrus--CA3 projection.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsy | 2001 |
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
Topics: 2-Amino-5-phosphonovalerate; Animals; C-Reactive Protein; Epilepsy; Excitatory Amino Acid Agonists; | 2001 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoreceptors; Calcium; Entorhinal Cortex; Epilepsy; Excitator | 2001 |
Potentially epileptogenic dysfunction of cortical NMDA- and GABA-mediated neurotransmission in Otx1-/- mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cell | 2001 |
Low concentration of DL-2-amino-5-phosphonovalerate induces epileptiform activity in guinea pig hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Culture Techniques; Dose-Response Relationship, Drug; Electroe | 2001 |
Effects of barium, furosemide, ouabaine and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) on ionophoretically-induced changes in extracellular potassium concentration in hippocampal slices from rats and from patients with epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics, Local; A | 2002 |
NMDA receptor activation mediates hydrogen peroxide-induced pathophysiology in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Hi | 2002 |
Single-electrode voltage-clamp analysis of the N-methyl-D-aspartate component of synaptic responses in neocortical slices from children with intractable epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Aging; Bicuculline; C | 1992 |
Contribution of amino acid transmitters to epileptiform activity and reflex suppression in electrically head stunned sheep.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Baclofen; Bicuculline; Blinking; | 1992 |
Protection from kainic acid neuropathological syndrome by NMDA receptor antagonists: effect of MK-801 and CGP 39551 on neurotransmitter and glial markers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Epilepsy; Kainic Acid; Male; Neuroglia; N | 1992 |
The contribution of AMPA and NMDA receptors to graded bursting activity in the hippocampal CA1 region in an acute in vitro model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Epilepsy; H | 1992 |
NMDA-receptor mediated electrical epileptogenesis in the organotypic culture of rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Hippocampus; Organ Culture Tec | 1992 |
Excitatory neurotransmitters in the lateral habenula and pedunculopontine nucleus of rat modulate limbic seizures induced by pilocarpine.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Electroencepha | 1992 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Initiation of epileptiform activity by excitatory amino acid receptors in the disinhibited rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cereb | 1991 |
Bicuculline-induced epileptogenesis in the human neocortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Po | 1991 |
Synaptic responses of guinea pig cingulate cortical neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Bicuculline; E | 1991 |
Transition from normal to epileptiform activity in kindled rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Cortical Spreading Depression; Electric Sti | 1991 |
NMDA receptor-mediated excitability in dendritically deformed dentate granule cells in pilocarpine-treated rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; I | 1991 |
The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Chronic Dis | 1991 |
Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Cerebral Corte | 1991 |
Excitatory synaptic involvement in epileptiform bursting in the immature rat neocortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Cerebral Cortex; | 1991 |
An NMDA-mediated component of excitatory synaptic input to dentate granule cells in 'epileptic' human hippocampus studied in vitro.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Electric Stimulation; Epilepsy; Hippocampus; Humans; | 1990 |
The role of excitatory amino acid receptors in the propagation of epileptiform discharges from the entorhinal cortex to the dentate gyrus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuc | 1990 |
NMDA receptor antagonists attenuate a portion of the penicillin-induced epileptiform burst.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro | 1990 |
Effect of APV and ketamine on epileptiform activity in the CA1 and CA3 regions of the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; Hippocampus; Ketamine; Male; Neurons; Rats; Rats, In | 1990 |
[Antagonist of NMDA receptor blocks epileptiform discharges in spinal motor neurons of the frog].
Topics: 2-Amino-5-phosphonovalerate; Animals; Epilepsy; In Vitro Techniques; Membrane Potentials; Motor Neur | 1990 |
Synaptic transmission in human neocortex removed for treatment of intractable epilepsy in children.
Topics: 2-Amino-5-phosphonovalerate; Adolescent; Bicuculline; Child; Child, Preschool; Epilepsy; Female; GAB | 1990 |
The excitatory amino acid antagonist amino-phosphono-valeric acid (APV) provides protection against penicillin-induced epileptic activity in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electroencephalography; Epilepsy; Male; Motor Activity; Penici | 1990 |
Epileptiform activity induced by 4-aminopyridine in rat amygdala neurons: the involvement of N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animal | 1990 |
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In | 1990 |
NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Culture Media; | 1990 |
The high pressure neurological syndrome in genetically epilepsy prone rats: protective effect of 2-amino-7-phosphono heptanoate.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Atmospheric Pressure; Epilepsy; Female; Male; Myo | 1991 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dos | 1990 |
Epileptiform activity in vitro can produce long-term synaptic failure and persistent neuronal depolarization.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Epilepsy; Hippocampus; In Vitr | 1989 |
Rat hippocampal slices 'in vitro' display spontaneous epileptiform activity following long-term organotypic culture.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Culture Techniques; Epilepsy; Hippocampus; | 1989 |
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr | 1989 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
Excitatory amino acid blockers differentially affect bursting of in vitro hippocampal neurons in two pharmacological models of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Guinea Pigs; Hippocampus; In Vitr | 1989 |
Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Electric Stimulation; Epilepsy; Guinea Pigs; Hippocampus; In V | 1985 |
A selective N-methyl-D-aspartate antagonist depresses epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Epilepsy; Evoked Potentials; Female; Folic Acid A | 1985 |
Extracellular studies on the role of N-methyl-D-aspartate receptors in epileptiform activity recorded from the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Epilepsy; Hippocampus; In Vitro Techniques; K | 1986 |
An N-methyl-D-aspartate (NMDA) receptor antagonist reduces bicuculline-induced depolarization shifts in neocortical explant cultures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Bicuculline; Cerebral Corte | 1986 |
Evidence for the activation of the N-methyl-D-aspartate receptor during epileptiform discharge.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Evoked Potential | 1986 |
The NMDA receptor antagonist 2-amino-5-phosphonovalerate blocks stimulus train-induced epileptogenesis but not epileptiform bursting in the rat hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Electric Stimulation; Electrophysiology; Epilep | 1987 |
Effects of ketamine and (+)cyclazocine on 4-aminopyridine and "magnesium free" epileptogenic activity in hippocampal slices of rats.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Aminopyridines; Animals; Aspartic Acid; Cyclazocine; E | 1987 |
The expression of N-methyl-D-aspartate-receptor-mediated component during epileptiform synaptic activity in hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Anticonvulsants; Epilepsy; Hippocampus; In | 1987 |
Comparison of kynurenic acid and 2-APV suppression of epileptiform activity in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Electrophysiology; Epilepsy; | 1988 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro | 1987 |
Epileptiform activity induced by magnesium-free solution in slices of rat amygdala: antagonism by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Epilepsy; In Vitro Techniques; Magn | 1988 |
Low-magnesium epilepsy in rat hippocampal slices: inhibitory postsynaptic potentials in the CA1 subfield.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebrospinal Fluid; Electric Stimulation; Electrophysiology; | 1988 |
Epileptiform events induced by GABA-antagonists in entorhinal cortical cells in vitro are partly mediated by N-methyl-D-aspartate receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cerebral Cortex; Epilepsy; In | 1988 |
Epigenetic control of epilepsy target genes contributes to a cellular memory of epileptogenesis in cultured rat hippocampal neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Cells, Cultured; DNA Methylation; Epigenesis, Genetic; | 2017 |
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec | 2015 |
Rapid plasticity at inhibitory and excitatory synapses in the hippocampus induced by ictal epileptiform discharges.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Biophysics; Calcium; Electric Stimulation; Epilepsy; | 2009 |
Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.
Topics: 4-Aminopyridine; Age Factors; Animals; Bicuculline; Brain; Convulsants; Electric Stimulation; Electr | 2011 |
Activation of long-term synaptic plasticity causes suppression of epileptiform activity in rat hippocampal slices.
Topics: Animals; Bicuculline; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation | 2004 |
Characterization of a fast transient outward current in neocortical neurons from epilepsy patients.
Topics: Adolescent; Adult; Anesthetics, Local; Anti-Arrhythmia Agents; Cadmium; Child, Preschool; Epilepsy; | 2004 |
Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit.
Topics: 4-Aminopyridine; Animals; Bicuculline; Drug Interactions; Electric Stimulation; Embryo, Mammalian; E | 2005 |
Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Excita | 2000 |
Chlormethiazole inhibits epileptiform activity by potentiating GABA(A) receptor function.
Topics: Action Potentials; Animals; Bicuculline; Cerebral Cortex; Chlormethiazole; Dose-Response Relationshi | 2000 |