2-amino-5-phosphonovalerate has been researched along with Epilepsy, Tonic-Clonic in 3 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Epilepsy, Tonic-Clonic: A generalized seizure disorder characterized by recurrent major motor seizures. The initial brief tonic phase is marked by trunk flexion followed by diffuse extension of the trunk and extremities. The clonic phase features rhythmic flexor contractions of the trunk and limbs, pupillary dilation, elevations of blood pressure and pulse, urinary incontinence, and tongue biting. This is followed by a profound state of depressed consciousness (post-ictal state) which gradually improves over minutes to hours. The disorder may be cryptogenic, familial, or symptomatic (caused by an identified disease process). (From Adams et al., Principles of Neurology, 6th ed, p329)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves were evaluated by means of an ethological method in which behavioral sequences typical of S and R animals were quantitated." | 1.29 | NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei. ( Garcia-Cairasco, N; Terra, VC, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terra, VC | 1 |
| Garcia-Cairasco, N | 1 |
| Velísek, L | 1 |
| Vachová, D | 1 |
| Mares, P | 1 |
| Engelsen, BA | 1 |
| Fonnum, F | 1 |
| Furset, K | 1 |
3 other studies available for 2-amino-5-phosphonovalerate and Epilepsy, Tonic-Clonic
| Article | Year |
|---|---|
NMDA-dependent audiogenic seizures are differentially regulated by inferior colliculus subnuclei.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Brain Mapp | 1994 |
Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis. IV. Effects of CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Drug Evaluation, Preclinical; Ep | 1997 |
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amino Acids; Animals; Anticonvulsants; Brain Mapping; Caudate | 1992 |