2-amino-5-phosphonovalerate has been researched along with Epilepsy, Temporal Lobe in 21 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "Seizures were blocked by glutamate receptor antagonists, suggesting that plasticity in excitatory synaptic circuits contributed to seizures." | 1.33 | Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus. ( Bausch, SB; He, S; McNamara, JO; Petrova, Y; Wang, XM, 2006) |
| "Neuropeptide Y (NPY) has been shown to depress hyperexcitable activity that has been acutely induced in the normal rat brain." | 1.30 | NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus. ( Patrylo, PR; Spencer, DD; van den Pol, AN; Williamson, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 11 (52.38) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ivanov, AD | 1 |
| Zaitsev, AV | 1 |
| Clasadonte, J | 1 |
| Dong, J | 1 |
| Hines, DJ | 1 |
| Haydon, PG | 1 |
| Langlois, M | 1 |
| Polack, PO | 1 |
| Bernard, H | 1 |
| David, O | 1 |
| Charpier, S | 1 |
| Depaulis, A | 1 |
| Deransart, C | 1 |
| Häussler, U | 1 |
| Bielefeld, L | 1 |
| Froriep, UP | 1 |
| Wolfart, J | 1 |
| Haas, CA | 1 |
| Abdelmalik, PA | 1 |
| Burnham, WM | 1 |
| Carlen, PL | 1 |
| Bausch, SB | 1 |
| He, S | 1 |
| Petrova, Y | 1 |
| Wang, XM | 1 |
| McNamara, JO | 1 |
| Bernard, CL | 1 |
| Wheal, HV | 1 |
| Williamson, A | 3 |
| Spencer, D | 1 |
| Uruno, K | 2 |
| O'Connor, MJ | 3 |
| Masukawa, LM | 3 |
| Buhl, EH | 1 |
| Otis, TS | 1 |
| Mody, I | 2 |
| Wang, H | 1 |
| Mangan, PS | 1 |
| Bertram, EH | 1 |
| Wu, C | 1 |
| Leung, LS | 1 |
| Patrylo, PR | 3 |
| Dudek, FE | 1 |
| Spencer, DD | 3 |
| van den Pol, AN | 1 |
| Kivi, A | 1 |
| Lehmann, TN | 1 |
| Kovács, R | 1 |
| Eilers, A | 1 |
| Jauch, R | 1 |
| Meencke, HJ | 1 |
| von Deimling, A | 1 |
| Heinemann, U | 2 |
| Gabriel, S | 1 |
| Behr, J | 1 |
| Higashima, M | 1 |
| Hart, GJ | 1 |
| Avoli, M | 1 |
| Olivier, A | 1 |
| Huberfeld, G | 1 |
| Menendez de la Prida, L | 1 |
| Pallud, J | 1 |
| Cohen, I | 1 |
| Le Van Quyen, M | 1 |
| Adam, C | 1 |
| Clemenceau, S | 1 |
| Baulac, M | 1 |
| Miles, R | 1 |
21 other studies available for 2-amino-5-phosphonovalerate and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Electroencephalography; Epilepsy, Temporal Lobe; E | 2013 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim | 2010 |
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Br | 2012 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
Plasticity of both excitatory and inhibitory synapses is associated with seizures induced by removal of chronic blockade of activity in cultured hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anesthetics, Local; Animals; Epilepsy, Temporal Lobe | 2006 |
Simultaneous expression of long-term depression of NMDA and long-term potentiation of AMPA receptor-mediated synaptic responses in the CA1 area of the kainic acid-lesioned hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Elect | 1995 |
Zinc reduces dentate granule cell hyperexcitability in epileptic humans.
Topics: 2-Amino-5-phosphonovalerate; Dentate Gyrus; Epilepsy, Temporal Lobe; Evoked Potentials; Humans; In V | 1995 |
Alterations of inhibitory synaptic responses in the dentate gyrus of temporal lobe epileptic patients.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adult; Bicucul | 1994 |
Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chlorides; Dentate Gyrus | 1996 |
Prolonged field potentials evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human brain slices.
Topics: 2-Amino-5-phosphonovalerate; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysiology; Ep | 1996 |
Shortened-duration GABA(A) receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Disea | 1997 |
Partial hippocampal kindling decreases efficacy of presynaptic GABAB autoreceptors in CA1.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Epile | 1997 |
Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Dentate Gyrus; Electric Stimulation; Electrophysi | 1998 |
Decrease in inhibition in dentate granule cells from patients with medial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Dentate Gyrus; Electric Conductiv | 1999 |
NPY inhibits glutamatergic excitation in the epileptic human dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Axons; Dentate Gyrus; Electric Stimulation; El | 1999 |
Effects of barium on stimulus-induced rises of [K+]o in human epileptic non-sclerotic and sclerotic hippocampal area CA1.
Topics: 2-Amino-5-phosphonovalerate; Adult; Barium Compounds; Bicuculline; Buffers; Chlorides; Electric Stim | 2000 |
Glutamate receptor activation in the kindled dentate gyrus.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Entorhinal Cortex; Epilepsy, Temporal Lobe; Exc | 2000 |
NMDA receptor activation during epileptiform responses in the dentate gyrus of epileptic patients.
Topics: 2-Amino-5-phosphonovalerate; Electric Stimulation; Epilepsy, Temporal Lobe; Evoked Potentials; Hippo | 1991 |
Bursting in human epileptogenic neocortex is depressed by an N-methyl-D-aspartate antagonist.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Anticonvulsants; Aspartic Acid; Epilepsy, Temporal L | 1987 |
Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy.
Topics: Action Potentials; Adolescent; Adult; Analysis of Variance; Biophysics; Brain Mapping; Confidence In | 2011 |