Page last updated: 2024-10-21

2-amino-5-phosphonovalerate and Dystonia

2-amino-5-phosphonovalerate has been researched along with Dystonia in 4 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)

Research Excerpts

ExcerptRelevanceReference
" In this model of paroxysmal dystonia, the noncompetitive NMDA receptor antagonists memantine and MK-801 (dizocilpine) delayed the progression of dystonic attacks in a dose-dependent fashion."7.68Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia. ( Fredow, G; Löscher, W; Richter, A, 1991)
" In this model of paroxysmal dystonia, the noncompetitive NMDA receptor antagonists memantine and MK-801 (dizocilpine) delayed the progression of dystonic attacks in a dose-dependent fashion."3.68Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia. ( Fredow, G; Löscher, W; Richter, A, 1991)
"In a model of paroxysmal dystonia, the dt(sz) mutant hamster, previous studies indicated striatal dysfunctions, including an increased long-term potentiation (LTP)."1.40Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. ( Avchalumov, Y; Bode, C; Hamann, M; Kirschstein, T; Köhling, R; Porath, K; Richter, A; Richter, F; Sander, SE, 2014)
"The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder."1.36Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010)
" The striatal application of NBQX reduced the severity and increased the latency to onset of dystonia significantly only at a dosage of 0."1.34Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant. ( Richter, A; Sander, SE, 2007)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Richter, A4
Fredow, G1
Löscher, W1
Avchalumov, Y1
Sander, SE3
Richter, F1
Porath, K1
Hamann, M2
Bode, C1
Kirschstein, T1
Köhling, R1
Kreil, A1

Other Studies

4 other studies available for 2-amino-5-phosphonovalerate and Dystonia

ArticleYear
Antidystonic effects of the NMDA receptor antagonists memantine, MK-801 and CGP 37849 in a mutant hamster model of paroxysmal dystonia.
    Neuroscience letters, 1991, Nov-25, Volume: 133, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cricetinae; Dizocilpine Maleate; Dose-Response Relationship, D

1991
Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.
    Experimental neurology, 2014, Volume: 261

    Topics: Animals; Animals, Newborn; Carrier Proteins; Corpus Striatum; Cricetinae; Cytoskeletal Proteins; Dis

2014
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
    Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:6

    Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru

2010
Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.
    European journal of pharmacology, 2007, Jun-01, Volume: 563, Issue:1-3

    Topics: Animals; Basal Ganglia; Caudate Nucleus; Cricetinae; Disease Models, Animal; Dizocilpine Maleate; Do

2007