2-amino-5-phosphonovalerate has been researched along with Disease Models, Animal in 120 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 7.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats." | 7.72 | Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 7.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 5.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "Pregnenolone sulfate (PREGS) is an excitatory neurosteroid that acts as a N-methyl-D-aspartate (NMDA) receptor agonist and GABAA receptor antagonist." | 5.42 | The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. ( Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L, 2015) |
| " Using a lithium-pilocarpine model to induce status epilepticus (SE) in rats, the present study investigated whether the induction of LTP was altered in hippocampal slices obtained 3 h, 1, 3, and 7 days after SE." | 3.83 | Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model. ( Kim, KK; Kryukov, KA; Magazanik, LG; Zaitsev, AV, 2016) |
| " Such insights prompted us to investigate the influence of dorsal hippocampal (CA1) NMDA receptor agents on amnesia induced by cannabinoid CB1 receptor agonist, arachidonylcyclopropylamide (ACPA) in male mice." | 3.81 | The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task. ( Amin-Yavari, S; Ebrahimi-Ghiri, M; Nasehi, M; Torabi-Nami, M; Zarrindast, MR, 2015) |
| "The obtained data suggest that stimulation of the glutamate or glycine recognition site of the NMDA receptor complex significantly decreases the antianxiety properties of antagonists of either site." | 3.79 | NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice. ( Dudka, J; Oniszczuk, T; Poleszak, E; Serefko, A; Szopa, A; Wlaź, P; Wośko, S; Wróbel, A, 2013) |
| " We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)." | 3.78 | Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| " The current study examined spinal coadministration of low doses of NMDA receptor antagonist, D-(-)-2-Amino-5-phosphonovalerate (D-APV), and mu-opioid receptor agonist, morphine sulfate (MS), in reducing visceral nociception using an acute bradykinin induced pancreatitis model in rats." | 3.72 | Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model. ( Lu, Y; Vera-Portocarrero, LP; Westlund, KN, 2003) |
| "Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival." | 3.70 | Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. ( Folbergrová, J; Haugvicová, R; Mares, P, 2000) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "We used a rat model of postoperative pain to investigate the effects of intra-RVM thalidomide treatments on postoperative pain, and evaluate the role of cannabinoid receptors in the effects of intra-RVM thalidomide treatments on GABAergic neurotransmission in the RVM neurons." | 1.48 | Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain. ( Gu, K; Jiang, B; Li, Y; Ma, P; Ma, X; Song, T; Wang, C; Yang, Y; Zhao, J, 2018) |
| "Temporal lobe epilepsy is usually associated with cognitive decline and memory deficits." | 1.46 | NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy. ( Ivanov, AD; Zaitsev, AV, 2017) |
| "The early phase of Alzheimer's disease (AD) is characterized by hippocampus-dependent memory deficits and impaired synaptic plasticity." | 1.42 | Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease. ( Barik, J; Bethus, I; Chafai, M; Kootar, S; Lanté, F; Marie, H; Mouska, X; Pereira, AR; Raymond, EF, 2015) |
| "Morphine has long been known to affect VTA DA cells via GABAergic interneurons." | 1.42 | Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal. ( Aston-Jones, G; Kaufling, J, 2015) |
| "Pregnenolone sulfate (PREGS) is an excitatory neurosteroid that acts as a N-methyl-D-aspartate (NMDA) receptor agonist and GABAA receptor antagonist." | 1.42 | The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats. ( Dastgheib, M; Dehpour, AR; Heidari, M; Moezi, L, 2015) |
| "These results suggest that IL-1β-induced mechanical allodynia is mediated by sensitized peripheral NMDA/AMPA receptors through PKA-mediated signaling in the large-diameter primary afferent nerve fibers, whereas IL-1β-induced thermal hyperalgesia is mediated by sensitized peripheral TRPV1 receptors through PKC-mediated signaling in the small-diameter primary afferent nerve fibers." | 1.40 | Differential regulation of peripheral IL-1β-induced mechanical allodynia and thermal hyperalgesia in rats. ( Ahn, DK; Bae, YC; Kim, HJ; Kim, MJ; Kim, YJ; Lee, SY; Nam, SH; Yang, KY, 2014) |
| "It was found that, following middle cerebral artery occlusion (MCAO), PSD-93 knockout (KO) mice manifested significant reductions in infarcted volume, neurological deficits and number of degenerated neurons." | 1.40 | PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia. ( Chen, L; Chen, X; Li, J; Li, Q; Shao, Y; Xu, Y; Zhang, M; Zhang, Q; Zhang, X, 2014) |
| "Dystonia is a movement disorder in which abnormal plasticity in the basal ganglia has been hypothesized to play a critical role." | 1.40 | Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia. ( Avchalumov, Y; Bode, C; Hamann, M; Kirschstein, T; Köhling, R; Porath, K; Richter, A; Richter, F; Sander, SE, 2014) |
| "In contrast, D-AP5-treated-tinnitus animals showed significantly less bilateral parafloccular and dorsal cochlear nucleus activity, as well as significantly less contralateral ventral cochlear nucleus activity." | 1.39 | Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model. ( Bauer, CA; Brozoski, TJ; Odintsov, B; Wisner, KW, 2013) |
| "Seizures were induced in 12-day-old rats by bilateral intracerebroventricular infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) and oxidative stress was evaluated by in situ detection of superoxide anion (O(2)·(-))." | 1.38 | Brain superoxide anion formation in immature rats during seizures: protection by selected compounds. ( Druga, R; Folbergrová, J; Otáhal, J, 2012) |
| " A sustained (>20 min) generalized convulsion was induced in Sprague-Dawley juvenile rats by intraperitoneal injection with pentylenetetrazole (PTZ, 70-90 mg/kg) at postnatal day (P) 20." | 1.38 | Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure. ( Mikroulis, AV; Psarropoulou, C, 2012) |
| "Neuropathic pain is a common cause of pain after nerve injury, but its molecular basis is poorly understood." | 1.38 | Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. ( Barres, B; Boroujerdi, A; Corpe, M; Deng, P; Eroglu, C; Kim, DS; Lee, J; Li, KW; Luo, ZD; Park, J; Peter Yu, Y; Sharp, K; Steward, O; Xu, ZC; Zaucke, F; Zhang, X; Zhou, CY, 2012) |
| "The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder." | 1.36 | Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010) |
| "In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known." | 1.35 | Abnormal network activity in a targeted genetic model of human double cortex. ( Ackman, JB; Aniksztejn, L; Becq, H; Ben-Ari, Y; Cardoso, C; Crépel, V; Pellegrino, C; Represa, A, 2009) |
| "Here, we used a freeze-induced model of cortical dysplasia to test the role of glutamate transporters in synaptic hyperexcitability." | 1.35 | Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia. ( Campbell, SL; Hablitz, JJ, 2008) |
| " The striatal application of NBQX reduced the severity and increased the latency to onset of dystonia significantly only at a dosage of 0." | 1.34 | Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant. ( Richter, A; Sander, SE, 2007) |
| "Complexin II is reduced in Huntington's disease (HD) patients and in the R6/2 mouse model of HD." | 1.33 | A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse. ( Brose, N; Gibson, HE; Jones, S; Morton, AJ; Reim, K, 2005) |
| "Secondary mechanical allodynia resulting from a thermal stimulus (52." | 1.33 | Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model. ( Jones, TL; Sorkin, LS, 2005) |
| "The pattern predicts why in PTSD patients, mild stressors cause reactions more appropriate for the original traumatic stressor and why new fears are so readily formed in these patients." | 1.33 | Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder. ( DeCola, JP; Fanselow, MS; Rau, V, 2005) |
| "HPNS is characterized by tremor, sleep disorders, electroencephalographic changes, and impairment of cognitive and motor performances." | 1.33 | Modulation of isolated N-methyl-d-aspartate receptor response under hyperbaric conditions. ( Grossman, Y; Mor, A, 2006) |
| "Limbic epilepsy is a chronic condition associated with a broad zone of seizure onset and pathology." | 1.31 | Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy. ( Bertram, EH; Mangan, PS; Scott, CA; Williamson, JM, 2000) |
| "In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures." | 1.28 | NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model. ( Anderson, WW; Clark, S; Stasheff, SF; Wilson, WA, 1989) |
| "Quinolinic acid (QA) is an endogenous excitotoxin present in mammalian brain that reproduces many of the histologic and neurochemical features of Huntington's disease (HD)." | 1.27 | Systemic approaches to modifying quinolinic acid striatal lesions in rats. ( Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.67) | 18.7374 |
| 1990's | 9 (7.50) | 18.2507 |
| 2000's | 48 (40.00) | 29.6817 |
| 2010's | 60 (50.00) | 24.3611 |
| 2020's | 1 (0.83) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 2 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 2 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Ivanov, AD | 1 |
| Zaitsev, AV | 2 |
| Zarrabian, S | 1 |
| Nasehi, M | 2 |
| Farrahizadeh, M | 1 |
| Zarrindast, MR | 2 |
| Joshi, K | 1 |
| Shen, L | 1 |
| Cao, F | 1 |
| Dong, S | 1 |
| Jia, Z | 1 |
| Cortez, MA | 2 |
| Snead, OC | 2 |
| Sartim, AG | 1 |
| Brito, BM | 1 |
| Gobira, PH | 1 |
| Joca, SRL | 1 |
| Brozoski, TJ | 1 |
| Wisner, KW | 1 |
| Odintsov, B | 1 |
| Bauer, CA | 1 |
| Poleszak, E | 1 |
| Serefko, A | 1 |
| Szopa, A | 1 |
| Wośko, S | 1 |
| Dudka, J | 1 |
| Wróbel, A | 1 |
| Oniszczuk, T | 1 |
| Wlaź, P | 1 |
| Kim, MJ | 1 |
| Lee, SY | 1 |
| Yang, KY | 1 |
| Nam, SH | 1 |
| Kim, HJ | 1 |
| Kim, YJ | 1 |
| Bae, YC | 1 |
| Ahn, DK | 1 |
| Amin-Yavari, S | 1 |
| Ebrahimi-Ghiri, M | 1 |
| Torabi-Nami, M | 1 |
| Dastgheib, M | 1 |
| Dehpour, AR | 1 |
| Heidari, M | 1 |
| Moezi, L | 1 |
| Mordel, J | 1 |
| Sheikh, A | 1 |
| Tsohataridis, S | 1 |
| Kanold, PO | 1 |
| Zehendner, CM | 1 |
| Luhmann, HJ | 1 |
| Palmer, CP | 1 |
| Metheny, HE | 1 |
| Elkind, JA | 1 |
| Cohen, AS | 1 |
| Kryukov, KA | 1 |
| Kim, KK | 1 |
| Magazanik, LG | 1 |
| Ryan, BK | 1 |
| Anwyl, R | 1 |
| Rowan, MJ | 1 |
| Campbell, SL | 1 |
| Hablitz, JJ | 1 |
| Li, Y | 3 |
| Lei, Z | 1 |
| Xu, ZC | 2 |
| Dong, XD | 1 |
| Svensson, P | 1 |
| Cairns, BE | 2 |
| Margaryan, G | 1 |
| Mattioli, C | 1 |
| Mladinic, M | 1 |
| Nistri, A | 1 |
| Langlois, M | 1 |
| Polack, PO | 1 |
| Bernard, H | 1 |
| David, O | 1 |
| Charpier, S | 1 |
| Depaulis, A | 1 |
| Deransart, C | 1 |
| Menzler, J | 1 |
| Zeck, G | 1 |
| Häussler, U | 1 |
| Bielefeld, L | 1 |
| Froriep, UP | 1 |
| Wolfart, J | 1 |
| Haas, CA | 1 |
| Kovács, Z | 1 |
| Czurkó, A | 1 |
| Kékesi, KA | 1 |
| Juhász, G | 1 |
| Khama-Murad, AKh | 1 |
| Barmashenko, G | 1 |
| Hefft, S | 1 |
| Aertsen, A | 1 |
| Kirschstein, T | 3 |
| Köhling, R | 3 |
| Heinl, C | 1 |
| Drdla-Schutting, R | 1 |
| Xanthos, DN | 1 |
| Sandkühler, J | 1 |
| Kernig, K | 1 |
| Würdemann, T | 1 |
| Rohde, M | 1 |
| Folbergrová, J | 2 |
| Otáhal, J | 1 |
| Druga, R | 1 |
| Wu, X | 2 |
| Shi, M | 1 |
| Wei, C | 1 |
| Yang, M | 1 |
| Liu, Y | 1 |
| Liu, Z | 1 |
| Zhang, X | 4 |
| Ren, W | 1 |
| Yuen, EY | 1 |
| Wei, J | 1 |
| Liu, W | 1 |
| Zhong, P | 1 |
| Li, X | 1 |
| Yan, Z | 1 |
| Mutso, AA | 1 |
| Radzicki, D | 2 |
| Baliki, MN | 1 |
| Huang, L | 1 |
| Banisadr, G | 1 |
| Centeno, MV | 1 |
| Radulovic, J | 1 |
| Martina, M | 3 |
| Miller, RJ | 1 |
| Apkarian, AV | 1 |
| Lu, Y | 1 |
| Vera-Portocarrero, LP | 1 |
| Westlund, KN | 3 |
| Hua, XY | 1 |
| Hayes, CS | 1 |
| Hofer, A | 1 |
| Fitzsimmons, B | 1 |
| Kilk, K | 1 |
| Langel, U | 1 |
| Bartfai, T | 1 |
| Yaksh, TL | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Tadano, T | 1 |
| Hozumi, S | 1 |
| Yamadera, F | 1 |
| Murata, A | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Nakagawasai, O | 1 |
| Kisara, K | 1 |
| Strauss, U | 1 |
| Kole, MH | 1 |
| Bräuer, AU | 1 |
| Pahnke, J | 1 |
| Bajorat, R | 1 |
| Rolfs, A | 1 |
| Nitsch, R | 1 |
| Deisz, RA | 1 |
| Neugebauer, V | 1 |
| Kleschevnikov, AM | 1 |
| Belichenko, PV | 1 |
| Villar, AJ | 1 |
| Epstein, CJ | 1 |
| Malenka, RC | 1 |
| Mobley, WC | 1 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 2 |
| Zhang, L | 3 |
| Carlen, PL | 2 |
| Badiu, CI | 1 |
| Raisinghani, M | 2 |
| Faingold, CL | 3 |
| Burnham, WM | 1 |
| Ro, JY | 1 |
| Nies, M | 1 |
| Zhang, Y | 1 |
| Isaev, D | 1 |
| Isaeva, E | 1 |
| Khazipov, R | 1 |
| Holmes, GL | 1 |
| Rau, V | 1 |
| DeCola, JP | 1 |
| Fanselow, MS | 1 |
| Jones, TL | 1 |
| Sorkin, LS | 1 |
| Gibson, HE | 1 |
| Reim, K | 1 |
| Brose, N | 1 |
| Morton, AJ | 1 |
| Jones, S | 1 |
| Wedzony, K | 3 |
| Fijał, K | 1 |
| Maćkowiak, M | 2 |
| Lin, C | 1 |
| Al-Chaer, ED | 1 |
| Nosyreva, ED | 1 |
| Huber, KM | 1 |
| Siegmund, A | 1 |
| Wotjak, CT | 1 |
| Murphy, GG | 1 |
| Shah, V | 1 |
| Hell, JW | 1 |
| Silva, AJ | 1 |
| Feng, HJ | 1 |
| Yang, L | 1 |
| Richichi, C | 1 |
| Brewster, AL | 1 |
| Bender, RA | 1 |
| Simeone, TA | 1 |
| Zha, Q | 1 |
| Yin, HZ | 1 |
| Weiss, JH | 1 |
| Baram, TZ | 1 |
| Glasscock, E | 1 |
| Qian, J | 1 |
| Yoo, JW | 1 |
| Noebels, JL | 1 |
| Gao, J | 1 |
| Yan, J | 1 |
| Fan, J | 1 |
| Owyang, C | 1 |
| Fijal, K | 1 |
| Chocyk, A | 1 |
| Zajaczkowski, W | 2 |
| Sluka, KA | 1 |
| Smith, SE | 1 |
| al-Zubaidy, ZA | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Avanzini, G | 1 |
| de Curtis, M | 2 |
| Franceschetti, S | 1 |
| Sancini, G | 1 |
| Spreafico, R | 1 |
| Mangan, PS | 2 |
| Bertram, EH | 2 |
| Radici, C | 1 |
| Forti, M | 1 |
| Chen, J | 1 |
| Li, H | 1 |
| Luo, C | 1 |
| Li, Z | 1 |
| Zheng, J | 1 |
| Karcz-Kubicha, M | 1 |
| Danysz, W | 1 |
| Haugvicová, R | 1 |
| Mares, P | 1 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| McKenna, JE | 1 |
| Melzack, R | 1 |
| Svensson, A | 1 |
| Carlsson, ML | 1 |
| Peeters, BW | 1 |
| van Rijn, CM | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Beal, MF | 1 |
| Kowall, NW | 1 |
| Swartz, KJ | 1 |
| Ferrante, RJ | 1 |
| Martin, JB | 1 |
| Stasheff, SF | 1 |
| Anderson, WW | 1 |
| Clark, S | 1 |
| Wilson, WA | 1 |
| Vascak, M | 1 |
| Jin, X | 1 |
| Jacobs, KM | 1 |
| Povlishock, JT | 1 |
| Song, T | 1 |
| Ma, X | 1 |
| Ma, P | 1 |
| Gu, K | 1 |
| Zhao, J | 1 |
| Yang, Y | 1 |
| Jiang, B | 1 |
| Wang, C | 1 |
| Shi, TY | 1 |
| Feng, SF | 1 |
| Wei, MX | 1 |
| Huang, Y | 2 |
| Liu, G | 1 |
| Wu, HT | 1 |
| Zhang, YX | 1 |
| Zhou, WX | 1 |
| Kelly, CJ | 1 |
| López-Huerta, VG | 1 |
| Carrillo-Reid, L | 1 |
| Galarraga, E | 1 |
| Tapia, D | 1 |
| Fiordelisio, T | 1 |
| Drucker-Colin, R | 1 |
| Bargas, J | 1 |
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120 other studies available for 2-amino-5-phosphonovalerate and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
NMDAR-independent hippocampal long-term depression impairment after status epilepticus in a lithium-pilocarpine model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Mode | 2017 |
The role of CA3 GABA
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Avoidance Learning; Baclofen; CA3 Region, Hippocampal | 2017 |
Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relatio | 2018 |
Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Apomorphine; Arginine; Capsaicin; Cycli | 2019 |
Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Auditory Cortex; Auditory Threshold; Cer | 2013 |
NMDA receptor activation antagonizes the NMDA antagonist-induced antianxiety effect in the elevated plus-maze test in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Binding Sites; | 2013 |
Differential regulation of peripheral IL-1β-induced mechanical allodynia and thermal hyperalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Disease Models, Animal; Diterpenes; Dose-Response Relationship | 2014 |
The dual effect of CA1 NMDA receptor modulation on ACPA-induced amnesia in step-down passive avoidance learning task.
Topics: 2-Amino-5-phosphonovalerate; Amnesia; Analysis of Variance; Animals; Arachidonic Acids; Avoidance Le | 2015 |
The effects of intra-dorsal hippocampus infusion of pregnenolone sulfate on memory function and hippocampal BDNF mRNA expression of biliary cirrhosis-induced memory impairment in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bile Ducts; Brain-Derived Neurotrophic Factor; CA1 Region, Hip | 2015 |
Mild systemic inflammation and moderate hypoxia transiently alter neuronal excitability in mouse somatosensory cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2016 |
Diminished amygdala activation and behavioral threat response following traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain Injuries | 2016 |
Status epilepticus alters hippocampal long-term synaptic potentiation in a rat lithium-pilocarpine model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Hippocam | 2016 |
5-HT2 receptor-mediated reversal of the inhibition of hippocampal long-term potentiation by acute inescapable stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cinanserin; Disease Models, Animal; Dose-Response Relationship | 2008 |
Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic A | 2008 |
Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Biophysics; | 2009 |
The analgesic action of topical diclofenac may be mediated through peripheral NMDA receptor antagonism.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, | 2009 |
Neuroprotection of locomotor networks after experimental injury to the neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cell S | 2010 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim | 2010 |
Network oscillations in rod-degenerated mouse retinas.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase | 2011 |
Septotemporal position in the hippocampal formation determines epileptic and neurogenic activity in temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Br | 2012 |
Intracerebroventricularly administered lipopolysaccharide enhances spike-wave discharges in freely moving WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyt | 2011 |
[Edema in nervous tissue studied on model of hemorrhagic stroke in vitro].
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Edema; Disease Models, Animal; Excitatory Amino Acid Ant | 2011 |
Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2011 |
Distinct mechanisms underlying pronociceptive effects of opioids.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Rela | 2011 |
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; CA1 R | 2012 |
Brain superoxide anion formation in immature rats during seizures: protection by selected compounds.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Anim | 2012 |
Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analysis of Variance | 2012 |
Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Bi | 2012 |
Abnormalities in hippocampal functioning with persistent pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Biophysics; Bromodeoxyuridine; Conditioning, | 2012 |
Intrathecal coadministration of D-APV and morphine is maximally effective in a rat experimental pancreatitis model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bradykinin; Disease Models, Animal; Drug Therapy, Combination; | 2003 |
Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Disease Models, Animal; Drug Synergism; Galanin; I | 2004 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Avoidance Learning; Cycloserine; Disease Models, Animal; Dizoc | 2004 |
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Brain; Disease Models, Animal; Dose-Respons | 2004 |
Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amygdala; Analysis of Variance; Animals; Arthritis; | 2004 |
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Crosses, Genetic; Dentate Gyrus; Disease | 2004 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
Sensitivity of thalamic GABAergic currents to clonazepam does not differ between control and genetic absence epilepsy rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Antic | 2004 |
Neurons in the amygdala play an important role in the neuronal network mediating a clonic form of audiogenic seizures both before and after audiogenic kindling.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Amygdala; Animals; Behavior, A | 2005 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
The role of peripheral N-methyl-D-aspartate receptors in muscle hyperalgesia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bite Force; Disease Models, Animal; Dose-Response Relationship | 2005 |
Evidence for the perirhinal cortex as a requisite component in the seizure network following seizure repetition in an inherited form of generalized clonic seizures.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Analysis of Variance; Animals; | 2005 |
Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicucu | 2005 |
Stress-induced enhancement of fear learning: an animal model of posttraumatic stress disorder.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Co | 2005 |
Activated PKA and PKC, but not CaMKIIalpha, are required for AMPA/Kainate-mediated pain behavior in the thermal stimulus model.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Area | 2005 |
A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.
Topics: 2-Amino-5-phosphonovalerate; Adaptor Proteins, Vesicular Transport; Age Factors; Animals; Anticonvul | 2005 |
Alterations in the dendritic morphology of prefrontal pyramidal neurons in adult rats after blockade of NMDA receptors in the postnatal period.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Cell Count; Dendrites; Disease Models, Anima | 2005 |
Differential effects of glutamate receptor antagonists on dorsal horn neurons responding to colorectal distension in a neonatal colon irritation rat model.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Cathet | 2005 |
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anisomycin; Blotting, Western; Disease Models, Animal; Drug In | 2006 |
Hyperarousal does not depend on trauma-related contextual memory in an animal model of Posttraumatic Stress Disorder.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Association Learning; Conditioning, Clas | 2007 |
Investigation of age-related cognitive decline using mice as a model system: neurophysiological correlates.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium; Calcium Channels, L-Type; Cognition Disorders; | 2006 |
Role of the amygdala in ethanol withdrawal seizures.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Action Potentials; Alcohol Withdrawal Seizures; A | 2007 |
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Cal | 2008 |
Masking epilepsy by combining two epilepsy genes.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Calcium Channel Blockers; Calcium Channels, N-Typ | 2007 |
Role for NMDA receptors in visceral nociceptive transmission in the anterior cingulate cortex of viscerally hypersensitive rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anaphylaxis; Animals; Cerebral Co | 2008 |
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, | 2008 |
Spinal cord amino acid release and content in an arthritis model: the effects of pretreatment with non-NMDA, NMDA, and NK1 receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Arthritis; | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Cortical versus thalamic mechanisms underlying spike and wave discharges in GAERS.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Disease | 1996 |
Shortened-duration GABA(A) receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Disea | 1997 |
Cellular mechanisms underlying spontaneous interictal spikes in an acute model of focal cortical epileptogenesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Acute Disease; | 1999 |
Involvement of peripheral NMDA and non-NMDA receptors in development of persistent firing of spinal wide-dynamic-range neurons induced by subcutaneous bee venom injection in the cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bee V | 1999 |
NMDA receptor antagonists acting at the glycineB site in rat models for antipsychotic-like activity.
Topics: 2-Amino-5-phosphonovalerate; Amphetamine; Animals; Antimetabolites; Antipsychotic Agents; Binding Si | 1999 |
Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; Age Factors; Animals; Cerebral Cortex; Disease Models, Animal; Dizocilp | 2000 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, An | 2001 |
Injection of the competitive NMDA receptor antagonist AP-5 into the nucleus accumbens of monoamine-depleted mice induces pronounced locomotor stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Biogenic Monoamines; Clonidine; Disease Models, Animal; Drug S | 1992 |
Involvement of NMDA receptors in non-convulsive epilepsy in WAG/Rij rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Brain; Disease Models, Animal; Dos | 1990 |
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Stria | 1988 |
NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Dibenzocycloheptenes; Disease | 1989 |
Mild Traumatic Brain Injury Induces Structural and Functional Disconnection of Local Neocortical Inhibitory Networks via Parvalbumin Interneuron Diffuse Axonal Injury.
Topics: Action Potentials; Animals; Brain Injuries, Traumatic; Diffuse Axonal Injury; Disease Models, Animal | 2018 |
Administrations of thalidomide into the rostral ventromedial medulla produce antinociceptive effects in a rat model of postoperative pain.
Topics: Analgesics; Animals; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists | 2018 |
Kainate receptor mediated presynaptic LTP in agranular insular cortex contributes to fear and anxiety in mice.
Topics: Animals; Anxiety; Cerebral Cortex; Conditioning, Classical; Disease Models, Animal; Disks Large Homo | 2018 |
Circuit-selective properties of glutamatergic inputs to the rat prelimbic cortex and their alterations in neuropathic pain.
Topics: Action Potentials; Animals; Animals, Newborn; Channelrhodopsins; Disease Models, Animal; Excitatory | 2018 |
The balance of striatal feedback transmission is disrupted in a model of parkinsonism.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adrenergic Agents; Anesthetics, Local; Anim | 2013 |
Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Cells, Cultured; C | 2013 |
BLA to vHPC inputs modulate anxiety-related behaviors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Anxiety; Bacterial Proteins; Calcium-Calmod | 2013 |
Altered cognitive performance and synaptic function in the hippocampus of mice lacking C3.
Topics: Animals; Animals, Newborn; Avoidance Learning; Cognition Disorders; Complement C3; Disease Models, A | 2014 |
Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Stem; Disease Models, Animal; Excitatory Amino | 2014 |
PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Disks Large Homolo | 2014 |
Long-term temporal imprecision of information coding in the anterior cingulate cortex of mice with peripheral inflammation or nerve injury.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Cognition; Disease Models, Animal; | 2014 |
Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.
Topics: Animals; Animals, Newborn; Carrier Proteins; Corpus Striatum; Cricetinae; Cytoskeletal Proteins; Dis | 2014 |
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec | 2015 |
Participation of NMDA receptors in the lateral hypothalamus in gastric erosion induced by cold-water restraint.
Topics: Analysis of Variance; Animals; Cold Temperature; Disease Models, Animal; Excitatory Amino Acid Agoni | 2015 |
Rapid antidepressants stimulate the decoupling of GABA(B) receptors from GIRK/Kir3 channels through increased protein stability of 14-3-3η.
Topics: 14-3-3 Proteins; Animals; Animals, Newborn; Antidepressive Agents; Cells, Cultured; Disease Models, | 2015 |
Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Dexamethasone; Disease Models, Animal; E | 2015 |
Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.
Topics: Animals; Biotinylation; Disease Models, Animal; Excitatory Amino Acid Antagonists; GABA Agonists; Ge | 2015 |
Glutamate Decarboxylase 67 Deficiency in a Subset of GABAergic Neurons Induces Schizophrenia-Related Phenotypes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Actins; Action Potentials; Animals; Dendrites; Disease Models, | 2015 |
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathways; Animals; Channelrhodopsi | 2015 |
The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
Topics: Animals; Animals, Newborn; Brain; Brain-Derived Neurotrophic Factor; Calcium Channel Blockers; Cells | 2016 |
Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice.
Topics: Animals; Dentate Gyrus; Disease Models, Animal; Estrous Cycle; Female; Fragile X Mental Retardation | 2016 |
Disinhibition of the intergeniculate leaflet network in the WAG/Rij rat model of absence epilepsy.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Animals, Newborn; Disease Models, Animal | 2017 |
Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.
Topics: Acetylcholine; Action Potentials; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2017 |
Formation and maintenance of ventilatory long-term facilitation require NMDA but not non-NMDA receptors in awake rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Disease Models, Animal; Excitatory Amino Acid Antagon | 2008 |
Abnormal network activity in a targeted genetic model of human double cortex.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Bicuculline; Cerebra | 2009 |
Severity of atypical absence phenotype in GABAB transgenic mice is subunit specific.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Autoradiography; Cognition Disorder | 2009 |
NMDA receptor blockage with 2-amino-5-phosphonovaleric acid improves oxidative stress after spinal cord trauma in rats.
Topics: Animals; Disease Models, Animal; Glutathione; Malondialdehyde; Neuroprotective Agents; Oxidative Str | 2010 |
Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington's disease.
Topics: Animals; Biophysics; Chi-Square Distribution; Corpus Striatum; Disease Models, Animal; Electric Stim | 2009 |
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estro | 2010 |
GPI-1046 increases presenilin-1 expression and restores NMDA channel activity.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonis | 2010 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr | 2012 |
Endogenous ACh effects on NMDA-induced interictal-like discharges along the septotemporal hippocampal axis of adult rats and their modulation by an early life generalized seizure.
Topics: Acetylcholine; Analysis of Variance; Animals; Atropine; Cholinesterase Inhibitors; Convulsants; Dise | 2012 |
Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Antibodies; Disease Models, Ani | 2012 |
Enhanced NMDA receptor-dependent thalamic excitation and network oscillations in stargazer mice.
Topics: Action Potentials; Animals; Biophysical Phenomena; Calcium Channels; Disease Models, Animal; Electri | 2012 |
Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex.
Topics: Anesthetics, Local; Animals; Bacterial Proteins; Carrier Proteins; Channelrhodopsins; Disease Models | 2012 |
Diabetes onset influences hippocampal synaptic plasticity in streptozotocin-treated rats.
Topics: Age Factors; Age of Onset; Analysis of Variance; Animals; Animals, Newborn; Biophysics; Diabetes Mel | 2012 |
Altered long-term corticostriatal synaptic plasticity in transgenic mice overexpressing human CU/ZN superoxide dismutase (GLY(93)-->ALA) mutation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Action Potentials; Alanine; Animals; Avo | 2003 |
Glutamate release in the nucleus accumbens is involved in behavioral depression during the PORSOLT swim test.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Re | 2003 |
Restoration of spontaneous exploratory behaviors with an intrathecal NMDA receptor antagonist or a PKC inhibitor in rats with acute pancreatitis.
Topics: Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2004 |
Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Electromyogra | 2005 |
Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Age Factors; Animals; Calcium Channel Block | 2006 |
Modulation of isolated N-methyl-d-aspartate receptor response under hyperbaric conditions.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radia | 2006 |
Effects of intrastriatal injections of glutamate receptor antagonists on the severity of paroxysmal dystonia in the dtsz mutant.
Topics: Animals; Basal Ganglia; Caudate Nucleus; Cricetinae; Disease Models, Animal; Dizocilpine Maleate; Do | 2007 |
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An | 2008 |
Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino | 2000 |
Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy.
Topics: Action Potentials; Amygdala; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy; Excita | 2000 |