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2-amino-5-phosphonovalerate and Diathesis

2-amino-5-phosphonovalerate has been researched along with Diathesis in 6 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Research Excerpts

ExcerptRelevanceReference
" Seizures were evoked with bicuculline (3."7.70The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000)
" Motor limbic seizures induced by pilocarpine, 380 mg/kg intraperitoneally, are prevented by prior injection into the substantia nigra, pars reticulata, or the entopeduncular nucleus, of 2-APH, 10 nmol or 10 pmol, respectively."4.77Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists. ( de Sarro, G; Meldrum, B; Millan, M; Patel, S, 1988)
" Seizures were evoked with bicuculline (3."3.70The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia. ( Czuczwar, SJ; Kleinrok, Z; Rejdak, K; Rejdak, R; Sieklucka-Dziuba, M, 2000)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's2 (33.33)18.2507
2000's3 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Norris, CM1
Korol, DL1
Foster, TC1
Di Loreto, S1
Balestrino, M1
Rejdak, K1
Rejdak, R1
Czuczwar, SJ1
Kleinrok, Z1
Sieklucka-Dziuba, M1
Yang, L1
Long, C1
Faingold, CL1
Golarai, G1
Greenwood, AC1
Feeney, DM1
Connor, JA1
Meldrum, B1
Millan, M1
Patel, S1
de Sarro, G1

Reviews

1 review available for 2-amino-5-phosphonovalerate and Diathesis

ArticleYear
Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists.
    Journal of neural transmission, 1988, Volume: 72, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Disease Su

1988

Other Studies

5 other studies available for 2-amino-5-phosphonovalerate and Diathesis

ArticleYear
Increased susceptibility to induction of long-term depression and long-term potentiation reversal during aging.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, Sep-01, Volume: 16, Issue:17

    Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Calcium; Disease Susceptibility; In Vitro Techniques; L

1996
Development of vulnerability to hypoxic damage in in vitro hippocampal neurons.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1997, Volume: 15, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Disease Susceptibility; Embryo, Mammalian; Embryonic and Fetal

1997
The influence of CGP-40116 on bicuculline evoked seizures in mice exposed to transient episode of brain oligemia.
    Journal of neural transmission (Vienna, Austria : 1996), 2000, Volume: 107, Issue:11

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; D

2000
Audiogenic seizure susceptibility is induced by termination of continuous infusion of gamma-aminobutyric acid or an N-methyl-D-aspartic acid Antagonist into the inferior colliculus.
    Experimental neurology, 2001, Volume: 171, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Behavior, Animal; Catheterization; Disea

2001
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Nov-01, Volume: 21, Issue:21

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta

2001