2-amino-5-phosphonovalerate has been researched along with Deficiency, Magnesium in 12 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Application of APV and nifedipine exacerbated low Mg(2+)-induced ILEs in the hippocampus but not the neocortex, indicating a distinct pharmacology for partial seizures of different brain regions." | 3.73 | Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro. ( Abdelmalik, PA; Burnham, WM; Carlen, PL, 2005) |
| "The behavioral changes associated with seizures induced by auditory stimulation in magnesium (Mg)-deficient rats originate in deep brain structures and secondarily project to neocortex." | 1.29 | In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers. ( Abe, S; Akazawa, K; Chishaki, A; Goto, Y; Kato, M; Nakamura, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulyás-Kovács, A | 1 |
| Dóczi, J | 1 |
| Tarnawa, I | 1 |
| Détári, L | 1 |
| Banczerowski-Pelyhe, I | 1 |
| Világi, I | 1 |
| Derchansky, M | 1 |
| Shahar, E | 1 |
| Wennberg, RA | 1 |
| Samoilova, M | 1 |
| Jahromi, SS | 1 |
| Abdelmalik, PA | 2 |
| Zhang, L | 1 |
| Carlen, PL | 2 |
| Burnham, WM | 1 |
| Nakamura, M | 1 |
| Abe, S | 1 |
| Goto, Y | 1 |
| Chishaki, A | 1 |
| Akazawa, K | 1 |
| Kato, M | 1 |
| Hsu, KS | 1 |
| Ho, WC | 1 |
| Huang, CC | 1 |
| Tsai, JJ | 1 |
| Takuma, S | 1 |
| Mizuno, T | 1 |
| Kanazawa, I | 1 |
| Sakurai, M | 1 |
| Dreier, JP | 1 |
| Heinemann, U | 1 |
| Gean, PW | 1 |
| Nakanishi, H | 1 |
| Kamata, O | 1 |
| Katsuda, N | 1 |
| Aram, JA | 1 |
| Lodge, D | 1 |
| Tancredi, V | 1 |
| Avoli, M | 1 |
| Hwa, GG | 1 |
12 other studies available for 2-amino-5-phosphonovalerate and Deficiency, Magnesium
| Article | Year |
|---|---|
Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Anti-Anxiety Agents; Benzodiazepines; Bicucul | 2002 |
Model of frequent, recurrent, and spontaneous seizures in the intact mouse hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; A | 2004 |
Increased seizure susceptibility of the hippocampus compared with the neocortex of the immature mouse brain in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channel Blockers | 2005 |
In vivo assessment of prevention of white-noise-induced seizure in magnesium-deficient rats by N-methyl-D-aspartate receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Body Weight; Dizocilpine Maleate | 1994 |
Transient removal of extracellular Mg(2+) elicits persistent suppression of LTP at hippocampal CA1 synapses via PKC activation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Ca | 2000 |
Effect of neonatal capsaicin treatment on neural activity in the medullary dorsal horn of neonatal rats evoked by electrical stimulation to the trigeminal afferents: an optical, electrophysiological, and quantitative study.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathw | 2001 |
Differential induction of LTP and LTD is not determined solely by instantaneous calcium concentration: an essential involvement of a temporal factor.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Signali | 2001 |
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In | 1990 |
NMDA receptor-independent epileptiform activity induced by magnesium-free solution in rat amygdala neurons is blocked by CNQX.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Culture Media; | 1990 |
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform discharge following a brief hypoxic episode in the hippocampal slices prepared from dietary Mg-deficient mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Diet; Epilepsy; Hippocampus; Hypoxia; In Vitr | 1989 |
Epileptiform activity induced by alkalosis in rat neocortical slices: block by antagonists of N-methyl-D-aspartate.
Topics: 2-Amino-5-phosphonovalerate; Alkalosis; Animals; Aspartic Acid; Cerebral Cortex; Epilepsy; In Vitro | 1987 |
Low-magnesium epilepsy in rat hippocampal slices: inhibitory postsynaptic potentials in the CA1 subfield.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebrospinal Fluid; Electric Stimulation; Electrophysiology; | 1988 |