2-amino-5-phosphonovalerate has been researched along with Cocaine-Related Disorders in 8 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terrier, J | 1 |
| Lüscher, C | 2 |
| Pascoli, V | 1 |
| Harris, GC | 1 |
| Aston-Jones, G | 1 |
| Bäckström, P | 1 |
| Hyytiä, P | 1 |
| Famous, KR | 1 |
| Schmidt, HD | 1 |
| Pierce, RC | 1 |
| Covington, HE | 1 |
| Tropea, TF | 1 |
| Rajadhyaksha, AM | 1 |
| Kosofsky, BE | 1 |
| Miczek, KA | 1 |
| Cornish, JL | 1 |
| Duffy, P | 1 |
| Kalivas, PW | 1 |
| Di Ciano, P | 1 |
| Everitt, BJ | 1 |
| Engblom, D | 1 |
| Bilbao, A | 1 |
| Sanchis-Segura, C | 1 |
| Dahan, L | 1 |
| Perreau-Lenz, S | 1 |
| Balland, B | 1 |
| Parkitna, JR | 1 |
| Luján, R | 1 |
| Halbout, B | 1 |
| Mameli, M | 1 |
| Parlato, R | 1 |
| Sprengel, R | 1 |
| Schütz, G | 1 |
| Spanagel, R | 1 |
8 other studies available for 2-amino-5-phosphonovalerate and Cocaine-Related Disorders
| Article | Year |
|---|---|
Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking, and Incubation of Craving.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Opera | 2016 |
Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related | 2003 |
Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cocaine; Cocaine-Related | 2007 |
When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors | 2007 |
NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blotting, Western; Cocaine-Related Disorders; Conditioning, Op | 2008 |
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4- | 1999 |
Dissociable effects of antagonism of NMDA and AMPA/KA receptors in the nucleus accumbens core and shell on cocaine-seeking behavior.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cocaine-Related Disorders; Conditioning, Operant; Dose-Respons | 2001 |
Glutamate receptors on dopamine neurons control the persistence of cocaine seeking.
Topics: Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Operant; Dopamine; Excitatory Am | 2008 |