2-amino-5-phosphonovalerate has been researched along with Chronic Illness in 12 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In contrast, D-AP5-treated-tinnitus animals showed significantly less bilateral parafloccular and dorsal cochlear nucleus activity, as well as significantly less contralateral ventral cochlear nucleus activity." | 1.39 | Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model. ( Bauer, CA; Brozoski, TJ; Odintsov, B; Wisner, KW, 2013) |
| " In contrast, in human neocortical preparations obtained from epilepsy surgery, in approximately 20% of the slices spontaneous epileptiform activity appeared with this bicuculline dosage without SDs." | 1.32 | Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue. ( Hagemann, G; Koch, UR; Köhling, R; Redecker, C; Speckmann, EJ; Straub, H, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brozoski, TJ | 1 |
| Wisner, KW | 1 |
| Odintsov, B | 1 |
| Bauer, CA | 1 |
| Xu, B | 1 |
| Zheng, H | 1 |
| Patel, KP | 1 |
| Köhling, R | 1 |
| Koch, UR | 1 |
| Hagemann, G | 1 |
| Redecker, C | 1 |
| Straub, H | 1 |
| Speckmann, EJ | 1 |
| Nishiyama, T | 1 |
| Neugebauer, V | 1 |
| Lücke, T | 1 |
| Grubb, B | 1 |
| Schaible, HG | 1 |
| Rice, ASC | 1 |
| McMahon, SB | 1 |
| Watts, AE | 1 |
| Whittington, MA | 1 |
| Jefferys, JG | 1 |
| Muñoz, MD | 1 |
| Monfort, P | 1 |
| Gaztelu, JM | 1 |
| Felipo, V | 1 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Simpson, LH | 1 |
| Wheal, HV | 1 |
| Williamson, R | 1 |
| Chiu, HF | 1 |
| Cheng, JK | 1 |
| Lin, PH | 1 |
| Chang, JC | 1 |
| Chen, IM | 1 |
| Lin, CI | 1 |
| Chang, WP | 1 |
| Lin, CH | 1 |
| Bennett, AD | 1 |
| Everhart, AW | 1 |
| Hulsebosch, CE | 1 |
12 other studies available for 2-amino-5-phosphonovalerate and Chronic Illness
| Article | Year |
|---|---|
Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Auditory Cortex; Auditory Threshold; Cer | 2013 |
Enhanced activation of RVLM-projecting PVN neurons in rats with chronic heart failure.
Topics: 2-Amino-5-phosphonovalerate; Animals; Chronic Disease; Coronary Vessels; Electric Stimulation; Elect | 2012 |
Differential sensitivity to induction of spreading depression by partial disinhibition in chronically epileptic human and rat as compared to native rat neocortical tissue.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chronic Disease; Cortical Spreading Depression; D | 2003 |
Interaction between a NMDA receptor antagonist, AP-5 and an AMPA receptor antagonist, YM 872 in antinociception in the spinal cord.
Topics: 2-Amino-5-phosphonovalerate; Acute Disease; Analgesics; Animals; Chronic Disease; Dose-Response Rela | 2008 |
The involvement of N-methyl-D-aspartate (NMDA) and non-NMDA receptors in the responsiveness of rat spinal neurons with input from the chronically inflamed ankle.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Animals; Ankle | 1994 |
Pre-emptive intrathecal administration of an NMDA receptor antagonist (AP-5) prevents hyper-reflexia in a model of persistent visceral pain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Chronic Disease; Cystitis; Differential Threshold; Dose-Respon | 1994 |
Epileptic focus induced in rat by intrahippocampal cholera toxin: neuronal properties in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Baclo | 1993 |
Hyperammonemia impairs NMDA receptor-dependent long-term potentiation in the CA1 of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; Ammonia; Animals; Chronic Disease; Electric Stimulation; Excitatory Pos | 2000 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
The contribution of non-NMDA and NMDA receptors to graded bursting activity in the CA1 region of the hippocampus in a chronic model of epilepsy.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Chronic Dis | 1991 |
A mechanistic study on urine retention in d-amphetamine addicts.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Afferent Pathways; Amidines; Amphetamine-Related Disorders; An | 2014 |
Intrathecal administration of an NMDA or a non-NMDA receptor antagonist reduces mechanical but not thermal allodynia in a rodent model of chronic central pain after spinal cord injury.
Topics: Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino | 2000 |