2-amino-5-phosphonovalerate has been researched along with Cerebral Ischemia in 31 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)." | 3.78 | Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012) |
| "In an in vitro model of cerebral ischemia we investigated the functional consequences of repeated hypoxias and the potential protective effect of the N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV) and the calcium channel blocker verapamil in preventing the expression of pathophysiological activity." | 3.68 | Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia. ( Heinemann, U; Kral, T; Luhmann, HJ; Mittmann, T, 1993) |
| "Acidosis accompanying cerebral ischemia activates acid-sensing ion channels (ASIC) causing increases in intracellular calcium concentration ([Ca(2+)]i) and enhanced neuronal death." | 1.36 | ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ( Cuevas, J; Katnik, C; Mari, Y, 2010) |
| "Focal cerebral ischemia was induced in rats by permanent occlusion of the left middle cerebral artery (MCA)." | 1.29 | The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia. ( Allegrini, PR; Fagg, GE; Sauer, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 14 (45.16) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, H | 1 |
| Jalini, S | 1 |
| Zhang, L | 1 |
| Charlton, M | 1 |
| Carlen, PL | 1 |
| Mari, Y | 1 |
| Katnik, C | 1 |
| Cuevas, J | 1 |
| Morgan, TE | 1 |
| Davis, DA | 1 |
| Iwata, N | 1 |
| Tanner, JA | 1 |
| Snyder, D | 1 |
| Ning, Z | 1 |
| Kam, W | 1 |
| Hsu, YT | 1 |
| Winkler, JW | 1 |
| Chen, JC | 1 |
| Petasis, NA | 1 |
| Baudry, M | 1 |
| Sioutas, C | 1 |
| Finch, CE | 1 |
| Yao, W | 1 |
| Ji, F | 1 |
| Chen, Z | 1 |
| Zhang, N | 1 |
| Ren, SQ | 1 |
| Zhang, XY | 1 |
| Liu, SY | 1 |
| Lu, W | 1 |
| Krebs, C | 1 |
| Fernandes, HB | 1 |
| Sheldon, C | 1 |
| Raymond, LA | 1 |
| Baimbridge, KG | 1 |
| Wang, JH | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Simon, RP | 1 |
| Swan, JH | 2 |
| Griffiths, T | 1 |
| Meldrum, BS | 2 |
| Puel, JL | 1 |
| Pujol, R | 1 |
| Tribillac, F | 1 |
| Ladrech, S | 1 |
| Eybalin, M | 1 |
| Virgili, M | 1 |
| Contestabile, A | 1 |
| Barnabei, O | 1 |
| Sauer, D | 3 |
| Allegrini, PR | 3 |
| Fagg, GE | 3 |
| Carletti, R | 1 |
| Ratti, E | 1 |
| Gaviraghi, G | 1 |
| Bowery, NG | 1 |
| Cosenti, A | 1 |
| Pataki, A | 1 |
| Amacker, H | 2 |
| Kral, T | 1 |
| Luhmann, HJ | 1 |
| Mittmann, T | 1 |
| Heinemann, U | 1 |
| Kasischke, K | 1 |
| Ludolph, AC | 1 |
| Riepe, MW | 1 |
| Okada, M | 2 |
| Fujimura, Y | 1 |
| Ueda, H | 2 |
| Kometani, M | 2 |
| Nakao, K | 2 |
| Inukai, T | 1 |
| Obeidat, AS | 1 |
| Jarvis, CR | 1 |
| Andrew, RD | 1 |
| Kulik, A | 1 |
| Trapp, S | 1 |
| Ballanyi, K | 1 |
| Jabaudon, D | 1 |
| Scanziani, M | 1 |
| Gähwiler, BH | 1 |
| Gerber, U | 1 |
| Andreeva, NA | 1 |
| Stel'mashuk, EV | 1 |
| Isaev, NK | 1 |
| Ostrovskaya, RU | 1 |
| Gudasheva, TA | 1 |
| Viktorov, IV | 1 |
| Zhang, Y | 1 |
| Wong, KC | 1 |
| Hayes, JK | 1 |
| Plachinta, R | 1 |
| Martin, P | 1 |
| Bernasconi, R | 1 |
| Nellgård, B | 1 |
| Wieloch, T | 1 |
| Bazil, MK | 1 |
| Gordon, FJ | 1 |
| Tombaugh, GC | 1 |
| Sapolsky, RM | 1 |
| Jensen, ML | 1 |
| Auer, RN | 1 |
| Hagberg, H | 1 |
| Andersson, P | 1 |
| Butcher, S | 1 |
| Sandberg, M | 1 |
| Lehmann, A | 1 |
| Hamberger, A | 1 |
| Li, L | 1 |
| Yang, R | 1 |
| Sun, K | 1 |
| Bai, Y | 1 |
| Zhang, Z | 1 |
| Zhou, L | 1 |
| Qi, Z | 1 |
| Qi, J | 1 |
| Chen, L | 1 |
| Kang, TH | 1 |
| Murakami, Y | 1 |
| Takayama, H | 1 |
| Kitajima, M | 1 |
| Aimi, N | 1 |
| Watanabe, H | 1 |
| Matsumoto, K | 1 |
31 other studies available for 2-amino-5-phosphonovalerate and Cerebral Ischemia
| Article | Year |
|---|---|
Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2010 |
ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Topics: 2-Amino-5-phosphonovalerate; Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; | 2010 |
Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Glutamic Aci | 2011 |
Glycine exerts dual roles in ischemic injury through distinct mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glucose; Gly | 2012 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Ce | 2003 |
Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Anima | 2003 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Hippocampus; Rats; Receptors, N-M | 1984 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; | 1994 |
Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Dizocilpine Maleate; Excitatory A | 1995 |
The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Dizocilpine Maleate; Dose-Resp | 1994 |
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebra | 1994 |
Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Brain Edema; Brain Ischemia; Cats | 1993 |
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Calcium; Calcium Channels; Electrophysiology; | 1993 |
NMDA-antagonists reverse increased hypoxic tolerance by preceding chemical hypoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; | 1996 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on ischemic brain damage induced by four-vessel occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Avoidance Learning; Brain Chemistry; B | 1997 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on focal cerebral ischemia in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cats; Cerebral Infarction; Excitatory A | 1997 |
Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Cortical | 2000 |
Ischemia but not anoxia evokes vesicular and Ca(2+)-independent glutamate release in the dorsal vagal complex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding C | 2000 |
Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebellum; Dipeptides; Gluco | 2000 |
Excitatory amino acid receptor antagonist 2APH may improve local CBF during cerebral ischemia in cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Excitatory | 2001 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn | 1992 |
Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Cell Death; Dizocilpine Maleat | 1992 |
Effect of blockade of spinal NMDA receptors on sympathoexcitation and cardiovascular responses produced by cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Ischemia; Cardiovascular Sy | 1991 |
Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen-Ion Conce | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Isch | 1990 |
Intraventricular infusion of 2-amino-7-phosphonoheptanoate (APH) mitigates ischaemic brain damage.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Injections, Intraventricular; Mal | 1989 |
Blockade of N-methyl-D-aspartate-sensitive acidic amino acid receptors inhibits ischemia-induced accumulation of purine catabolites in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Brain Ischemia; Corpus Striatum; Hypoxanthine; Hypo | 1986 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr | 2012 |
Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action.
Topics: Alkaloids; Animals; Brain Ischemia; Cell Hypoxia; Hippocampus; In Vitro Techniques; Indole Alkaloids | 2004 |