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2-amino-5-phosphonovalerate and Cerebral Infarction

2-amino-5-phosphonovalerate has been researched along with Cerebral Infarction in 5 studies

2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).

Research Excerpts

ExcerptRelevanceReference
" We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)."3.78Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Neumann-Haefelin, T1
Hagemann, G1
Witte, OW1
Carletti, R1
Ratti, E1
Gaviraghi, G1
Bowery, NG1
Okada, M1
Ueda, H1
Kometani, M1
Nakao, K1
Sauer, D1
Martin, P1
Allegrini, PR1
Bernasconi, R1
Amacker, H1
Fagg, GE1
Li, L1
Yang, R1
Sun, K1
Bai, Y1
Zhang, Z1
Zhou, L1
Qi, Z1
Qi, J1
Chen, L1

Other Studies

5 other studies available for 2-amino-5-phosphonovalerate and Cerebral Infarction

ArticleYear
Cellular correlates of neuronal hyperexcitability in the vicinity of photochemically induced cortical infarcts in rats in vitro.
    Neuroscience letters, 1995, Jun-30, Volume: 193, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cerebral Infarction; Electrophysiology; gamma

1995
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
    Neuropharmacology, 1994, Volume: 33, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebra

1994
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on focal cerebral ischemia in cat.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cats; Cerebral Infarction; Excitatory A

1997
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
    Neuroscience letters, 1992, Jul-20, Volume: 141, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn

1992
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
    The international journal of neuropsychopharmacology, 2012, Volume: 15, Issue:4

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr

2012