2-amino-5-phosphonovalerate has been researched along with Cerebral Infarction in 5 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)." | 3.78 | Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neumann-Haefelin, T | 1 |
| Hagemann, G | 1 |
| Witte, OW | 1 |
| Carletti, R | 1 |
| Ratti, E | 1 |
| Gaviraghi, G | 1 |
| Bowery, NG | 1 |
| Okada, M | 1 |
| Ueda, H | 1 |
| Kometani, M | 1 |
| Nakao, K | 1 |
| Sauer, D | 1 |
| Martin, P | 1 |
| Allegrini, PR | 1 |
| Bernasconi, R | 1 |
| Amacker, H | 1 |
| Fagg, GE | 1 |
| Li, L | 1 |
| Yang, R | 1 |
| Sun, K | 1 |
| Bai, Y | 1 |
| Zhang, Z | 1 |
| Zhou, L | 1 |
| Qi, Z | 1 |
| Qi, J | 1 |
| Chen, L | 1 |
5 other studies available for 2-amino-5-phosphonovalerate and Cerebral Infarction
| Article | Year |
|---|---|
Cellular correlates of neuronal hyperexcitability in the vicinity of photochemically induced cortical infarcts in rats in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cerebral Cortex; Cerebral Infarction; Electrophysiology; gamma | 1995 |
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebra | 1994 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on focal cerebral ischemia in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cats; Cerebral Infarction; Excitatory A | 1997 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn | 1992 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr | 2012 |