2-amino-5-phosphonovalerate has been researched along with Cerebral Cortical Dysplasia in 2 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here, we used a freeze-induced model of cortical dysplasia to test the role of glutamate transporters in synaptic hyperexcitability." | 1.35 | Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia. ( Campbell, SL; Hablitz, JJ, 2008) |
| "In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known." | 1.35 | Abnormal network activity in a targeted genetic model of human double cortex. ( Ackman, JB; Aniksztejn, L; Becq, H; Ben-Ari, Y; Cardoso, C; Crépel, V; Pellegrino, C; Represa, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Campbell, SL | 1 |
| Hablitz, JJ | 1 |
| Ackman, JB | 1 |
| Aniksztejn, L | 1 |
| Crépel, V | 1 |
| Becq, H | 1 |
| Pellegrino, C | 1 |
| Cardoso, C | 1 |
| Ben-Ari, Y | 1 |
| Represa, A | 1 |
2 other studies available for 2-amino-5-phosphonovalerate and Cerebral Cortical Dysplasia
| Article | Year |
|---|---|
Decreased glutamate transport enhances excitability in a rat model of cortical dysplasia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic A | 2008 |
Abnormal network activity in a targeted genetic model of human double cortex.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Bicuculline; Cerebra | 2009 |