2-amino-5-phosphonovalerate has been researched along with Brain Ischemia in 31 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We herein report that treatment with CS-A after 60-min middle cerebral artery occlusion dose-dependently reduced the cerebral infarction with at least a 6-h efficacious time-window, which was partially blocked by the BKCa channel blocker charybdotoxin (CTX)." | 3.78 | Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors. ( Bai, Y; Chen, L; Li, L; Qi, J; Qi, Z; Sun, K; Yang, R; Zhang, Z; Zhou, L, 2012) |
| "In an in vitro model of cerebral ischemia we investigated the functional consequences of repeated hypoxias and the potential protective effect of the N-methyl-D-aspartate (NMDA) receptor antagonist D-2-amino-5-phosphonovaleric acid (D-APV) and the calcium channel blocker verapamil in preventing the expression of pathophysiological activity." | 3.68 | Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia. ( Heinemann, U; Kral, T; Luhmann, HJ; Mittmann, T, 1993) |
| "Acidosis accompanying cerebral ischemia activates acid-sensing ion channels (ASIC) causing increases in intracellular calcium concentration ([Ca(2+)]i) and enhanced neuronal death." | 1.36 | ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis. ( Cuevas, J; Katnik, C; Mari, Y, 2010) |
| "Focal cerebral ischemia was induced in rats by permanent occlusion of the left middle cerebral artery (MCA)." | 1.29 | The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia. ( Allegrini, PR; Fagg, GE; Sauer, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 14 (45.16) | 18.2507 |
| 2000's | 9 (29.03) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ye, H | 1 |
| Jalini, S | 1 |
| Zhang, L | 1 |
| Charlton, M | 1 |
| Carlen, PL | 1 |
| Mari, Y | 1 |
| Katnik, C | 1 |
| Cuevas, J | 1 |
| Morgan, TE | 1 |
| Davis, DA | 1 |
| Iwata, N | 1 |
| Tanner, JA | 1 |
| Snyder, D | 1 |
| Ning, Z | 1 |
| Kam, W | 1 |
| Hsu, YT | 1 |
| Winkler, JW | 1 |
| Chen, JC | 1 |
| Petasis, NA | 1 |
| Baudry, M | 1 |
| Sioutas, C | 1 |
| Finch, CE | 1 |
| Yao, W | 1 |
| Ji, F | 1 |
| Chen, Z | 1 |
| Zhang, N | 1 |
| Ren, SQ | 1 |
| Zhang, XY | 1 |
| Liu, SY | 1 |
| Lu, W | 1 |
| Krebs, C | 1 |
| Fernandes, HB | 1 |
| Sheldon, C | 1 |
| Raymond, LA | 1 |
| Baimbridge, KG | 1 |
| Wang, JH | 1 |
| Katchanov, J | 1 |
| Waeber, C | 1 |
| Gertz, K | 1 |
| Gietz, A | 1 |
| Winter, B | 1 |
| Brück, W | 1 |
| Dirnagl, U | 1 |
| Veh, RW | 1 |
| Endres, M | 1 |
| Simon, RP | 1 |
| Swan, JH | 2 |
| Griffiths, T | 1 |
| Meldrum, BS | 2 |
| Puel, JL | 1 |
| Pujol, R | 1 |
| Tribillac, F | 1 |
| Ladrech, S | 1 |
| Eybalin, M | 1 |
| Virgili, M | 1 |
| Contestabile, A | 1 |
| Barnabei, O | 1 |
| Sauer, D | 3 |
| Allegrini, PR | 3 |
| Fagg, GE | 3 |
| Carletti, R | 1 |
| Ratti, E | 1 |
| Gaviraghi, G | 1 |
| Bowery, NG | 1 |
| Cosenti, A | 1 |
| Pataki, A | 1 |
| Amacker, H | 2 |
| Kral, T | 1 |
| Luhmann, HJ | 1 |
| Mittmann, T | 1 |
| Heinemann, U | 1 |
| Kasischke, K | 1 |
| Ludolph, AC | 1 |
| Riepe, MW | 1 |
| Okada, M | 2 |
| Fujimura, Y | 1 |
| Ueda, H | 2 |
| Kometani, M | 2 |
| Nakao, K | 2 |
| Inukai, T | 1 |
| Obeidat, AS | 1 |
| Jarvis, CR | 1 |
| Andrew, RD | 1 |
| Kulik, A | 1 |
| Trapp, S | 1 |
| Ballanyi, K | 1 |
| Jabaudon, D | 1 |
| Scanziani, M | 1 |
| Gähwiler, BH | 1 |
| Gerber, U | 1 |
| Andreeva, NA | 1 |
| Stel'mashuk, EV | 1 |
| Isaev, NK | 1 |
| Ostrovskaya, RU | 1 |
| Gudasheva, TA | 1 |
| Viktorov, IV | 1 |
| Zhang, Y | 1 |
| Wong, KC | 1 |
| Hayes, JK | 1 |
| Plachinta, R | 1 |
| Martin, P | 1 |
| Bernasconi, R | 1 |
| Nellgård, B | 1 |
| Wieloch, T | 1 |
| Bazil, MK | 1 |
| Gordon, FJ | 1 |
| Tombaugh, GC | 1 |
| Sapolsky, RM | 1 |
| Jensen, ML | 1 |
| Auer, RN | 1 |
| Hagberg, H | 1 |
| Andersson, P | 1 |
| Butcher, S | 1 |
| Sandberg, M | 1 |
| Lehmann, A | 1 |
| Hamberger, A | 1 |
| Li, L | 1 |
| Yang, R | 1 |
| Sun, K | 1 |
| Bai, Y | 1 |
| Zhang, Z | 1 |
| Zhou, L | 1 |
| Qi, Z | 1 |
| Qi, J | 1 |
| Chen, L | 1 |
| Kang, TH | 1 |
| Murakami, Y | 1 |
| Takayama, H | 1 |
| Kitajima, M | 1 |
| Aimi, N | 1 |
| Watanabe, H | 1 |
| Matsumoto, K | 1 |
31 other studies available for 2-amino-5-phosphonovalerate and Brain Ischemia
| Article | Year |
|---|---|
Early ischemia enhances action potential-dependent, spontaneous glutamatergic responses in CA1 neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2010 |
ASIC1a channels are activated by endogenous protons during ischemia and contribute to synergistic potentiation of intracellular Ca(2+) overload during ischemia and acidosis.
Topics: 2-Amino-5-phosphonovalerate; Acid Sensing Ion Channels; Acidosis; Animals; Brain Ischemia; Calcium; | 2010 |
Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Glutamic Aci | 2011 |
Glycine exerts dual roles in ischemic injury through distinct mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glucose; Gly | 2012 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Astrocytes; Axotomy; Brain Ischemia; Calcium; Cell Hypoxia; Ce | 2003 |
Short-term cerebral ischemia causes the dysfunction of interneurons and more excitation of pyramidal neurons in rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Anima | 2003 |
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidotes; Antineoplastic Agents; Autoradiography; Binding Sit | 2003 |
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Hippocampus; Rats; Receptors, N-M | 1984 |
Excitatory amino acid antagonists protect cochlear auditory neurons from excitotoxicity.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; | 1994 |
Simultaneous blockade of non-NMDA ionotropic receptors and NMDA receptor-associated ionophore partially protects hippocampal slices from protein synthesis impairment due to simulated ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Dizocilpine Maleate; Excitatory A | 1995 |
The competitive NMDA receptor antagonist CGP 40116 is a potent neuroprotectant in a rat model of focal cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Dizocilpine Maleate; Dose-Resp | 1994 |
Comparative receptor autoradiography of ex vivo and in vitro [3H]dizocilpine binding in mouse brain after middle cerebral artery occlusion.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Binding Sites; Brain; Brain Ischemia; Cerebra | 1994 |
Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Brain Edema; Brain Ischemia; Cats | 1993 |
Role of NMDA receptors and voltage-activated calcium channels in an in vitro model of cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Calcium; Calcium Channels; Electrophysiology; | 1993 |
NMDA-antagonists reverse increased hypoxic tolerance by preceding chemical hypoxia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antihypertensive Agents; | 1996 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on ischemic brain damage induced by four-vessel occlusion in rats.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Avoidance Learning; Brain Chemistry; B | 1997 |
Effect of D-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid on focal cerebral ischemia in cat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cats; Cerebral Infarction; Excitatory A | 1997 |
Glutamate does not mediate acute neuronal damage after spreading depression induced by O2/glucose deprivation in the hippocampal slice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Ischemia; Cortical | 2000 |
Ischemia but not anoxia evokes vesicular and Ca(2+)-independent glutamate release in the dorsal vagal complex in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Brain | 2000 |
Acute decrease in net glutamate uptake during energy deprivation.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding C | 2000 |
Neuroprotective properties of nootropic dipeptide GVS-111 in in vitro oxygen-glucose deprivation, glutamate toxicity and oxidative stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cells, Cultured; Cerebellum; Dipeptides; Gluco | 2000 |
Excitatory amino acid receptor antagonist 2APH may improve local CBF during cerebral ischemia in cats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cats; Cerebrovascular Circulation; Excitatory | 2001 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn | 1992 |
Cerebral protection by AMPA- and NMDA-receptor antagonists administered after severe insulin-induced hypoglycemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Brain Ischemia; Cell Death; Dizocilpine Maleat | 1992 |
Effect of blockade of spinal NMDA receptors on sympathoexcitation and cardiovascular responses produced by cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Ischemia; Cardiovascular Sy | 1991 |
Mechanistic distinctions between excitotoxic and acidotic hippocampal damage in an in vitro model of ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Cell Survival; Hippocampus; Hydrogen-Ion Conce | 1990 |
Protection by NMDA antagonists against selective cell loss following transient ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Brain; Brain Isch | 1990 |
Intraventricular infusion of 2-amino-7-phosphonoheptanoate (APH) mitigates ischaemic brain damage.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Ischemia; Injections, Intraventricular; Mal | 1989 |
Blockade of N-methyl-D-aspartate-sensitive acidic amino acid receptors inhibits ischemia-induced accumulation of purine catabolites in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Animals; Brain Ischemia; Corpus Striatum; Hypoxanthine; Hypo | 1986 |
Cerebroside-A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Brain Ischemia; Calcium; Cerebr | 2012 |
Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action.
Topics: Alkaloids; Animals; Brain Ischemia; Cell Hypoxia; Hippocampus; In Vitro Techniques; Indole Alkaloids | 2004 |