2-amino-5-phosphonovalerate has been researched along with Brain Injuries in 14 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 7.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| " Here, we show that extracellular spermine, one of the endogenous polyamines, exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis." | 3.77 | Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. ( Cao, H; Chu, XP; Duan, B; Hansen, J; Huang, Y; Simon, RP; Wang, YZ; Xiong, ZG; Xu, TL; Yang, T; Yu, Y; Zhu, MX, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Palmer, CP | 1 |
| Metheny, HE | 1 |
| Elkind, JA | 1 |
| Cohen, AS | 1 |
| Seo, DO | 1 |
| Pang, MH | 1 |
| Shin, MS | 1 |
| Kim, HT | 1 |
| Choi, JS | 1 |
| Razak, KA | 1 |
| Huang, L | 1 |
| Pallas, SL | 1 |
| Petzold, GC | 1 |
| Windmüller, O | 1 |
| Haack, S | 1 |
| Major, S | 1 |
| Buchheim, K | 1 |
| Megow, D | 1 |
| Gabriel, S | 1 |
| Lehmann, TN | 1 |
| Drenckhahn, C | 1 |
| Peters, O | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Dirnagl, U | 1 |
| Dreier, JP | 1 |
| Jin, X | 1 |
| Prince, DA | 1 |
| Huguenard, JR | 1 |
| Goforth, PB | 1 |
| Ellis, EF | 1 |
| Satin, LS | 1 |
| Santhakumar, V | 1 |
| Bender, R | 1 |
| Frotscher, M | 1 |
| Ross, ST | 2 |
| Hollrigel, GS | 1 |
| Toth, Z | 1 |
| Soltesz, I | 2 |
| Golarai, G | 1 |
| Greenwood, AC | 1 |
| Feeney, DM | 1 |
| Connor, JA | 1 |
| Zhang, X | 1 |
| Liu, E | 1 |
| Liu, X | 1 |
| Dai, Q | 1 |
| Nichols, J | 1 |
| Perez, R | 1 |
| Wu, C | 1 |
| Adelson, PD | 1 |
| Anderson, T | 1 |
| Duan, B | 1 |
| Wang, YZ | 1 |
| Yang, T | 1 |
| Chu, XP | 1 |
| Yu, Y | 1 |
| Huang, Y | 1 |
| Cao, H | 1 |
| Hansen, J | 1 |
| Simon, RP | 1 |
| Zhu, MX | 1 |
| Xiong, ZG | 1 |
| Xu, TL | 1 |
| Dzhala, V | 1 |
| Valeeva, G | 1 |
| Glykys, J | 1 |
| Khazipov, R | 1 |
| Staley, K | 1 |
| Suma, T | 1 |
| Koshinaga, M | 1 |
| Fukushima, M | 1 |
| Kano, T | 1 |
| Katayama, Y | 1 |
14 other studies available for 2-amino-5-phosphonovalerate and Brain Injuries
| Article | Year |
|---|---|
Diminished amygdala activation and behavioral threat response following traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Brain Injuries | 2016 |
Hippocampal NMDA receptors are necessary for auditory trace fear conditioning measured with conditioned hypoalgesia in rats.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Animals; Association Learning; Behavior, Animal; | 2008 |
NMDA receptor blockade in the superior colliculus increases receptive field size without altering velocity and size tuning.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cricetinae; Electrophysiology; Excitatory Amin | 2003 |
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Body Temperature; Brain; Brain Injuries; Cortical Spreading De | 2005 |
Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Br | 2006 |
Enhancement of AMPA-mediated current after traumatic injury in cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anim | 1999 |
Granule cell hyperexcitability in the early post-traumatic rat dentate gyrus: the 'irritable mossy cell' hypothesis.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuc | 2000 |
Selective depolarization of interneurons in the early posttraumatic dentate gyrus: involvement of the Na(+)/K(+)-ATPase.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzo | 2000 |
Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cell Count; Cell Death; Chronic Disease; Denta | 2001 |
Changes in and effective factors of microtubule-associated protein 2 in traumatic neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Injuries; Cold Temperature; Fluorescent Antibody Techniq | 2001 |
Traumatic brain injury induces rapid enhancement of cortical excitability in juvenile rats.
Topics: Animals; Animals, Newborn; Biophysics; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Elec | 2015 |
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
Topics: Acid Sensing Ion Channels; Acidosis; Amino Acid Transport System y+; Animals; Biophysics; Brain Inju | 2011 |
Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Age Factors; Animals; Animals, Newborn; Ant | 2012 |
Effects of in situ administration of excitatory amino acid antagonists on rapid microglial and astroglial reactions in rat hippocampus following traumatic brain injury.
Topics: Animals; Astrocytes; Brain Injuries; CD11b Antigen; Disease Models, Animal; Excitatory Amino Acid An | 2008 |