2-amino-5-phosphonovalerate has been researched along with Brain Edema in 6 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Each of these could also contribute to cerebral edema, which is the primary cause of patient mortality after stroke." | 1.32 | Brain edema induced by in vitro ischemia: causal factors and neuroprotection. ( Avshalumov, MV; MacGregor, DG; Rice, ME, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khama-Murad, AKh | 1 |
| MacGregor, DG | 1 |
| Avshalumov, MV | 1 |
| Rice, ME | 1 |
| Sauer, D | 2 |
| Allegrini, PR | 2 |
| Cosenti, A | 1 |
| Pataki, A | 1 |
| Amacker, H | 2 |
| Fagg, GE | 2 |
| Häntzschel, A | 1 |
| Andreas, K | 1 |
| Thedinga, KH | 1 |
| Massieu, L | 1 |
| Mrsulja, BB | 1 |
| Stanimirović, D | 1 |
| Mićić, DV | 1 |
| Spatz, M | 1 |
6 other studies available for 2-amino-5-phosphonovalerate and Brain Edema
| Article | Year |
|---|---|
[Edema in nervous tissue studied on model of hemorrhagic stroke in vitro].
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Edema; Disease Models, Animal; Excitatory Amino Acid Ant | 2011 |
Brain edema induced by in vitro ischemia: causal factors and neuroprotection.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Antioxidants; Brain Edem | 2003 |
Characterization of the cerebroprotective efficacy of the competitive NMDA receptor antagonist CGP40116 in a rat model of focal cerebral ischemia: an in vivo magnetic resonance imaging study.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Brain; Brain Edema; Brain Ischemia; Cats | 1993 |
Efficacy of glutamate receptor antagonists in the management of functional disorders in cytotoxic brain oedema induced by hexachlorophene.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain; Brain Edema; Dizo | 1998 |
Evaluation of quinolinic acid induced excitotoxic neurodegeneration in rat striatum by quantitative magnetic resonance imaging in vivo.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Edema; Choline O-Acetyltransferase; Corpus Striat | 1992 |
Excitatory amino acid receptors, oxido-reductive processes and brain oedema following transient ischaemia in gerbils.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anions; Brain Edema; Female; Gerbillinae; Ischemi | 1990 |