2-amino-5-phosphonovalerate has been researched along with Brain Diseases in 5 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizures were observed 50 min after injecting Dtx (35 pmol) into the amygdala, though significant neuronal loss was not evident." | 1.28 | Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker. ( Bagetta, G; Dolly, JO; Nisticó, G, 1992) |
| " The antagonistic properties of kynurenate were dose-dependent: equimolar kynurenate had no effect on quinolinate but attenuated the actions of ibotenate, kainate and NMDA; 2 x equimolar kynurenate had no effect on quinolinate or ibotenate but attenuated the toxicity of kainate and NMDA; and 3 x equimolar kynurenate had no effect on the toxicity of kainate or ibotenate, attenuated the actions of NMDA and abolished the toxic action of quinolinate." | 1.28 | A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat. ( Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwarcz, R | 1 |
| Collins, JF | 1 |
| Parks, DA | 1 |
| Marret, S | 1 |
| Mukendi, R | 1 |
| Gadisseux, JF | 1 |
| Gressens, P | 1 |
| Evrard, P | 1 |
| Luhmann, HJ | 1 |
| Karpuk, N | 1 |
| Qü, M | 1 |
| Zilles, K | 1 |
| Bagetta, G | 1 |
| Nisticó, G | 1 |
| Dolly, JO | 1 |
| Winn, P | 1 |
| Stone, TW | 1 |
| Latimer, M | 1 |
| Hastings, MH | 1 |
| Clark, AJ | 1 |
5 other studies available for 2-amino-5-phosphonovalerate and Brain Diseases
| Article | Year |
|---|---|
alpha-Amino-omega-phosphono carboxylates block ibotenate but not kainate neurotoxicity in rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain Diseases; Hippocampus; Ibotenic Acid; Kaini | 1982 |
Effect of ibotenate on brain development: an excitotoxic mouse model of microgyria and posthypoxic-like lesions.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Amino Acids; Animals; Brain; Brain Diseases; Embryonic and Fet | 1995 |
Characterization of neuronal migration disorders in neocortical structures. II. Intracellular in vitro recordings.
Topics: 2-Amino-5-phosphonovalerate; Aging; Animals; Animals, Newborn; Brain Diseases; Cell Movement; Evoked | 1998 |
Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Diseases; Dizocilpine Maleate; Elapid Venoms; Electroenc | 1992 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic A | 1991 |