2-amino-5-phosphonovalerate has been researched along with Blood Pressure, High in 10 studies
2-Amino-5-phosphonovalerate: The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rilmenidine is a second-generation centrally acting antihypertensive drug that acts mainly through the activation of the imidazoline (I(1)) receptor in the rostral ventrolateral medulla (RVLM)." | 1.31 | The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats. ( Abdel-Rahman, AA; Zhang, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takakura, AC | 1 |
| Colombari, E | 1 |
| Menani, JV | 1 |
| Moreira, TS | 1 |
| Zhang, J | 1 |
| Abdel-Rahman, AA | 1 |
| Li, DP | 2 |
| Pan, HL | 2 |
| Lin, JC | 1 |
| Tsao, WL | 1 |
| Wang, Y | 2 |
| Maiorov, DN | 1 |
| Krenz, NR | 1 |
| Krassioukov, AV | 1 |
| Weaver, LC | 1 |
| Maione, S | 1 |
| Vitagliano, S | 1 |
| Berrino, L | 2 |
| Lampa, E | 1 |
| Rossi, F | 2 |
| Mills, E | 1 |
| Minson, J | 1 |
| Drolet, G | 1 |
| Chalmers, J | 1 |
| Kao, MC | 1 |
| Lee, HK | 1 |
| Chai, CY | 1 |
| Ye, ZY | 1 |
| Li, L | 1 |
| D'Amico, M | 1 |
| Pizzirusso, A | 1 |
| de Novellis, V | 1 |
10 other studies available for 2-amino-5-phosphonovalerate and Blood Pressure, High
| Article | Year |
|---|---|
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemor | 2011 |
The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hem | 2002 |
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertension.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Blood Pressure; Excitato | 2007 |
Cardiovascular effects of NMDA in the RVLM of spontaneously hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Carotid Arteries; Electric Stimulation; Hemody | 1995 |
Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Bloo | 1997 |
Participation of arginine vasopressin-mediated and adrenergic system-mediated mechanisms in the hypertension induced by intracerebroventricular administration of NMDA in freely moving rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine Vasopressin; Blood Pressure; Cerebral Ventricles; Clo | 1992 |
Effect of intrathecal amino acid receptor antagonists on basal blood pressure and pressor responses to brainstem stimulation in normotensive and hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Blood Pressure; Brain Stem; Cerebrovascular Disor | 1990 |
NMDA antagonists attenuate hypertension induced by carotid clamping in the rostral ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Anticonvulsants; Arterial Occl | 1991 |
Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension.
Topics: Animals; Benzimidazoles; Blood Pressure; Brain Stem; Casein Kinase II; Dichlororibofuranosylbenzimid | 2011 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycl | 1996 |